Targeting the α7 nicotinic acetylcholine receptor to prevent progressive dementia and improve cognition in adults with Down's syndrome

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 54, Issue , 2014, Pages 131-139

  Deutsch, Stephen I ^a   Burket, Jessica A ^a   Benson, Andrew D ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Amyloid peptides; Down's syndrome; Intellectual disability

Indexed keywords

A 582941; AMYLOID BETA PROTEIN[1-42]; BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR AGONIST; CALCIUM ION; NICOTINIC AGENT; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); NOOTROPIC AGENT; PEPTIDE FRAGMENT;

ADULT; ALZHEIMER DISEASE; CALCIUM CONDUCTANCE; COGNITION; DEMENTIA; DOWN SYNDROME; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG PENETRATION; DRUG TARGETING; ENDOCYTOSIS; FRONTOTEMPORAL DEMENTIA; HISTOPATHOLOGY; HUMAN; NERVE CELL EXCITABILITY; NEUROPATHOLOGY; NONHUMAN; PHARMACEUTICAL CARE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR OCCUPANCY; REVIEW; SEIZURE SUSCEPTIBILITY; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION; DEMENTIA; DOWN SYNDROME; HUMANS; NOOTROPIC AGENTS; PEPTIDE FRAGMENTS;

EID: 84902471740     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.05.011     Document Type: Review

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