α7 Nicotinic receptor agonist reactivates neurogenesis in adult brain

Biochemical Pharmacology

Volumn 86, Issue 8, 2013, Pages 1099-1104

  Narla, Sridhar ^a   Klejbor, Ilona ^b   Birkaya, Barbara ^a   Lee, Yu Wei ^a   Morys, Janusz ^b   Stachowiak, Ewa K ^a   Terranova, Christopher ^a   Bencherif, Merouane ^c   Stachowiak, Michal K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c TARGACEPT INC   (United States)

Author keywords

Brain; Neurogenesis; Nicotinic receptors; Nuclear FGF receptor; Stem cells

Indexed keywords

EID: 84885661521     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.07.028     Document Type: Review

References (50)

1. de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol 2006;5(6):525-35. (Pubitemid 44262284)
2. Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 2009;11(2):111-28.
3. Pringsheim T, et al. The incidence and prevalence of Huntington's disease: a systematic review and meta-Analysis. Mov Disord 2012;27(9):1083-91.
4. Boland DF, Stacy M. The economic and quality of life burden associated with Parkinson's disease: a focus on symptoms. Am J Manag Care 2012;18(7 Suppl):S168-75.
5. Gates MA, et al. Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres. J Comp Neurol 1995;361(2):249-66.
6. Kuhn HG, et al. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci 1997;17(15):5820-9. (Pubitemid 27310497)
7. Gage FH. Mammalian neural stem cells. Science 2000;287(5457):1433-8. (Pubitemid 30127128)
8. Gould E. How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 2007;8(6):481-8. (Pubitemid 46789229)
9. Resende RR, Adhikari A. Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. Cell Commun Signal 2009;7:20.
10. Broide RS, et al. Developmental expression of alpha 7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus. Neuroscience 1995;67(1):83-94.
11. Falk L, et al. Higher expression of alpha7 nicotinic acetylcholine receptors in human fetal compared to adult brain. Brain Res Dev Brain Res 2003;142(2):151-60. (Pubitemid 36593158)
12. Quik M, et al. Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization. J Comp Neurol 2000;425(1):58-69.
13. Adams CE, et al. Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. Brain Res Dev Brain Res 2002;139(2):175-87. (Pubitemid 35453904)
14. Quik M, Chan J, Patrick J. Alpha-bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line. Brain Res 1994;655(1-2):161-7.
15. Coronas V, et al. Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures. Neuroscience 2000;98(2):213-9. (Pubitemid 30347283)
16. Cui W, et al. Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR. Brain Res 2011;1401:10-7.
17. Campbell NR, et al. Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus. J Neurosci 2010;30(26):8734-44.
18. Paraoanu LE, et al. Expression and possible functions of the cholinergic system in a murine embryonic stem cell line. Life Sci 2007;80(24-25):2375-9. (Pubitemid 46818286)
19. Landgraf D, et al. Acetylcholine as a possible signaling molecule in embryonic stem cells: studies on survival, proliferation and death. Chem Biol Interact 2010;187(1-3):115-9.
20. Akinyemi RO. Epidemiology of Parkinsonism and Parkinson's disease in Sub-Saharan Africa: Nigerian profile. J Neurosci Rural Pract 2012;3(3):233-4.
21. Marrero MB, et al. An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes. J Pharmacol Exp Ther 2010;332(1):173-80.
22. Canavese G, et al. p27: a potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior. Hum Pathol 2001;32(10):1094-101. (Pubitemid 33015670)
23. Narla S, et al. Activation of developmental nuclear FGFR1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist. Stem Cells Transl Med 2013.
24. Jankovic J, Chen S, Le WD. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol 2005;77(1-2):128-38. (Pubitemid 41654775)
25. Baron O, et al. Cooperation of nuclear FGFR1 and Nurr1 offers a new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons. J Biol Chem 2012.
26. Klejbor I, et al. Fibroblast growth factor receptor signaling affects development and function of dopamine neurons -inhibition results in a schizophrenia-like syndrome in transgenic mice. J Neurochem 2006;97(5):1243-58. (Pubitemid 43725565)
27. Leung CT, Coulombe PA, Reed RR. Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nat Neurosci 2007;10(6):720-6. (Pubitemid 46828492)
28. Ren K, et al. Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells. J Neurochem 2005;94(4):926-33. (Pubitemid 41170581)
29. Mullenbrock S, Shah J, Cooper GM. Global expression analysis identified a preferentially NGF-induced transcriptional program regulated by sustained MEK/ERK and AP-1 activation during PC12 differentiation. J Biol Chem 2011.
30. Kudo TA, et al. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway. Gene Cell 2011;16(11):1121-32.
31. von Kriegsheim A, et al. Cell fate decisions are specified by the dynamic ERK interactome. Nat Cell Biol 2009;11(12):1458-64.
32. Stachowiak MK,Maher PA, Stachowiak EK. Integrative nuclear signaling in cell development -A role for FGF receptor-1. DNA Cell Biol 2007;26(12):811-26. (Pubitemid 350274413)
33. Stachowiak EK, Roy I, Stachowiak MK. Triggering neuronogenesis by endogenous brain stem cells with DNA nanoplexes. In: Stachowiak MK, Emmanuel ST, editors. Stem Cells from Mechanisms to Technologies, E.S.T. World Scientific Publishing; 2011. p. 333-59.
34. Fang X, et al. Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J Biol Chem 2005;280(31):28451-62. (Pubitemid 41105744)
35. Stachowiak EK, et al. cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1). J Neurochem 2003;84(6):1296-312. (Pubitemid 36343596)
36. Kim EL, Esparza FM, Stachowiak MK. The roles of CRE: TRE, and TRE-Adjacent S1 nuclease sensitive element in the regulation of tyrosine hydroxylase gene promoter activity by angiotensin II. J Neurochem 1996;67(1):26-36. (Pubitemid 26185577)
37. Stachowiak MK, et al. Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Mol Biol Cell 1996;7(8):1299-317. (Pubitemid 26262065)
38. Dunham-Ems SM, et al. Fibroblast Growth Factor Receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control. Mol Biol Cell 2009.
39. Myers JM, et al. Nuclear trafficking of FGFR1: a role for the transmembrane domain. J Cell Biochem 2003;88(6):1273-91. (Pubitemid 36397465)
40. Reilly JF, Maher PA. Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J Cell Biol 2001;152(6):1307-12. (Pubitemid 34280187)
41. Bharali DJ, et al. Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci U S A 2005;102(32):11539-44.
42. Stachowiak MK, et al. Integrative nuclear FGFR1 signaling (INFS) as a part of a universal feed-forward-And-gate'' signaling module that controls cell growth and differentiation. J Cell Biochem 2003;90(4):662-91. (Pubitemid 37392460)
43. Stachowiak EK, Roy I, Lee Y-W, Capacchietti M, Aletta JM, Prasad PN, et al. Targeting novel integrative nuclear FGFR1 signaling by nanoparticle-mediated genetransfer stimulatesneurogenesis inadult brain. IntegrBiol2009;1:394-403.
44. Lee YWet al. A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells. J Cell Biochem 2012.
45. Stachowiak MK. In: Emmanuel ST, editor. Stem Cells From Mechanisms to Technologies. World Scientific Publishing Company; 2011.
46. Klejbor I, et al. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophr Res 2009;113(2-3):308-21.
47. Hu Y, et al. 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. J Biol Chem 2004;279(28):29325-35. (Pubitemid 38915810)
48. Peng H, et al. Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors. Mol Biol Cell 2001;12(2):449-62. (Pubitemid 33051587)
49. Stachowiak EK, Roy I, Stachowiak MK. Triggering neuronogenesis by endogenous brain stem cells with DNA nanoplexes. In: Emmanuel ST, Stachowiak MK, editors. Stem Cells from Mechanisms to Technologies. World Scientific Publishing; 2011.
50. Maira M, et al. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase a pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol 2003;23(3):763-76. (Pubitemid 36133496)