Evaluation of skin regeneration after burns in vivo and rescue of cells after thermal stress in vitro following treatment with a keratin biomaterial

Journal of Biomaterials Applications

Volumn 29, Issue 1, 2014, Pages 26-35

  Poranki, D ^a   Whitener, W ^a   Howse, S ^a   Mesen, T ^a   Howse, E ^a   Burnell, J ^a   Greengauz Roberts, O ^a   Molnar, J ^a   Van Dyke, M ^a,b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

burn; heat shock; hydrogel; Keratin; skin; wound

Indexed keywords

CELL CULTURE; CELLS; HIGH TEMPERATURE EFFECTS; HYDROGELS; KERATIN; SKIN; TISSUE;

BURN; DERMAL FIBROBLASTS; DIFFERENTIAL EFFECT; HEAT-SHOCK; INTERMEDIATE ZONE; POTENTIAL THERAPIES; SKIN REGENERATION; WOUND;

MOLECULAR BIOLOGY;

BIOMATERIAL; KERATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURN; CELL DEATH; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CELL VIABILITY; CHEMICAL BURN; CONTROLLED STUDY; EVALUATION STUDY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKIN FIBROBLAST; SKIN REGENERATION; TEMPERATURE STRESS; THERMAL INJURY; TISSUE NECROSIS; WOUND CLOSURE; WOUND HEALING; YORKSHIRE PIG; ANIMAL; CELL CULTURE; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; HUMAN; ISOLATION AND PURIFICATION; MATERIALS TESTING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PIG; PILOT STUDY; REGENERATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; BURNS; BURNS, CHEMICAL; CELLS, CULTURED; HUMANS; HYDROGELS; KERATINS; MATERIALS TESTING; MICE; PILOT PROJECTS; REGENERATION; SKIN PHYSIOLOGICAL PHENOMENA; SUS SCROFA; WOUND HEALING;

EID: 84902368210     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328213513310     Document Type: Article

References (77)

1. Herndon DN Total burn care. 3 rd ed. Philadelphia, USA: Saunders Elsevier, 2007. Philadelphia, USA: Saunders Elsevier ; 2007 :
2. Alvarez O. Moist environment for healing: matching the dressing to the wound. Ostomy Wound Manage. 1988 ; 21: 64-83
3. Bryan J. Moist wound healing: a concept that changed our practice. J Wound Care. 2004 ; 13: 227-228
4. Chang H, Wind S, Kerstein MD. Moist wound healing. Dermatol Nurs. 1996 ; 8: 174-176
5. Ribeiro MP, Espiga A, Silva D, et al. Development of a new chitosan hydrogel for wound dressing. Wound Repair Regen. 2009 ; 17: 817-824
6. Alemdaroglu C, Degim Z, Celebi N, et al. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns. 2006 ; 32: 319-327
7. Boucard N, Viton C, Agay D, et al. The use of physical hydrogels of chitosan for skin regeneration following third-degree burns. Biomaterials. 2007 ; 28: 3478-3488
8. Jin Y, Ling PX, He YL, et al. Effects of chitosan and heparin on early extension of burns. Burns. 2007 ; 33: 1027-1031
9. Sezer AD, Cevher E, Hatipoglu F, et al. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biol Pharm Bull. 2008 ; 31: 2326-2333
10. Dai T, Tegos GP, Burkatovskaya M, et al. Chitosan acetate bandage as a topical antimicrobial dressing for infected burns. Antimicrob Agents Chemother. 2009 ; 53: 393-400
11. Nascimento EG, Sampaio TB, Medeiros AC, et al. Evaluation of chitosan gel with 1% silver sulfadiazine as an alternative for burn wound treatment in rats. Acta Cir Bras. 2009 ; 24: 460-465
12. Dantas MD, Cavalcante DR, Araujo FE, et al. Improvement of dermal burn healing by combining sodium alginate/chitosan-based films and low level laser therapy. J Photochem Photobiol B. 2011 ; 105: 51-59
13. Degim Z, Celebi N, Alemdaroglu C, et al. Evaluation of chitosan gel containing liposome-loaded epidermal growth factor on burn wound healing. Int Wound J. 2011 ; 8: 343-354
14. Alsarra IA. Chitosan topical gel formulation in the management of burn wounds. Int J Biol Macromol. 2009 ; 45: 16-21
15. Ishihara M, Obara K, Nakamura S, et al. Chitosan hydrogel as a drug delivery carrier to control angiogenesis. J Artif Organs. 2006 ; 9: 8-16
16. Choi JS, Yoo HS. Pluronic/chitosan hydrogels containing epidermal growth factor with wound-adhesive and photo-crosslinkable properties. J Biomed Mater Res A. 2010 ; 95: 564-573
17. Simsek S, Canter HI, Konas E, et al. A new concept in treatment of burn injury: controlled slow-release granulocyte-monocyte colony-stimulating factor chitosan gel system. Ann Plast Surg. 2011 ; 67: 583-588
18. Barnett SE, Varley SJ. The effects of calcium alginate on wound healing. Ann R Coll Surg Engl. 1987 ; 69: 153-155
19. Piacquadio D, Nelson DB. Alginates. A "new" dressing alternative. J Dermatol Surg Oncol. 1992 ; 18: 992-995
20. Agren MS. Four alginate dressings in the treatment of partial thickness wounds: a comparative experimental study. Br J Plast Surg. 1996 ; 49: 129-134
21. Williams C. Melgisorb: a highly absorbent calcium/sodium alginate dressing. Br J Nurs. 1998 ; 7: 975-976
22. Williams C. Tegagen alginate dressing for moderate to heavily exuding wounds. Br J Nurs. 1998 ; 7: 550-552
23. Williams C. Algosteril calcium alginate dressing for moderate/high exudate. Br J Nurs. 1999 ; 8: 313-317
24. Kammerlander G, Eberlein T. An assessment of the wound healing properties of Algisite M dressings. Nurs Times. 2003 ; 99: 54-56
25. Suzuki Y, Nishimura Y, Tanihara M, et al. Evaluation of a novel alginate gel dressing: cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo. J Biomed Mater Res. 1998 ; 39: 317-322
26. Suzuki Y, Tanihara M, Nishimura Y, et al. In vivo evaluation of a novel alginate dressing. J Biomed Mater Res. 1999 ; 48: 522-527
27. Horch RE, Stark GB. Comparison of the effect of a collagen dressing and a polyurethane dressing on the healing of split thickness skin graft (STSG) donor sites. Scand J Plast Reconstr Surg Hand Surg. 1998 ; 32: 407-413
28. Landsman A, Taft D, Riemer K. The role of collagen bioscaffolds, foamed collagen, and living skin equivalents in wound healing. Clin Podiatr Med Surg. 2009 ; 26: 525-533
29. Singh O, Gupta SS, Soni M, et al. Collagen dressing versus conventional dressings in burn and chronic wounds: a retrospective study. J Cutan Aesthet Surg. 2011 ; 4: 12-16
30. Adhirajan N, Shanmugasundaram N, Shanmuganathan S, et al. Collagen-based wound dressing for doxycycline delivery: in-vivo evaluation in an infected excisional wound model in rats. J Pharm Pharmacol. 2009 ; 61: 1617-1623
31. Kondo S, Niiyama H, Yu A, et al. Evaluation of a wound dressing composed of hyaluronic acid and collagen sponge containing epidermal growth factor in diabetic mice. J Biomater Sci Polym Ed. Epub ahead of print 22 September 2011. DOI: 10.1163/092050611X597799.
32. Nunes PS, Albuquerque RL Jr, Cavalcante DR, et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. J Biomed Biotechnol. 2011 ; 2011: 761593-761593
33. Uygur F, Evinc R, Ulkur E, et al. Use of lyophilized bovine collagen for split-thickness skin graft donor site management. Burns. 2008 ; 34: 1011-1014
34. Neely AN, Brown RL, Clendening CE, et al. Proteolytic activity in human burn wounds. Wound Repair Regen. 1997 ; 5: 302-309
35. Vloemans AF, Soesman AM, Suijker M, et al. A randomised clinical trial comparing a hydrocolloid-derived dressing and glycerol preserved allograft skin in the management of partial thickness burns. Burns. 2003 ; 29: 702-710
36. Thomas S. Hydrocolloid dressings in the management of acute wounds: a review of the literature. Int Wound J. 2008 ; 5: 602-613
37. Muangman P, Muangman S, Opasanon S, et al. Benefit of hydrocolloid SSD dressing in the outpatient management of partial thickness burns. J Med Assoc Thai. 2009 ; 92: 1300-1305
38. Qin Y. Silver-containing alginate fibres and dressings. Int Wound J. 2005 ; 2: 172-176
39. Opasanon S, Muangman P, Namviriyachote N. Clinical effectiveness of alginate silver dressing in outpatient management of partial-thickness burns. Int Wound J. 2010 ; 7: 467-471
40. Lu S, Gao W, Gu HY. Construction, application and biosafety of silver nanocrystalline chitosan wound dressing. Burns. 2008 ; 34: 623-628
41. Ong SY, Wu J, Moochhala SM, et al. Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials. 2008 ; 29: 4323-4332
42. Huang L, Dai T, Xuan Y, et al. Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother. 2011 ; 55: 3432-3438
43. Li D, Diao J, Zhang J, et al. Fabrication of new chitosan-based composite sponge containing silver nanoparticles and its antibacterial properties for wound dressing. J Nanosci Nanotechnol. 2011 ; 11: 4733-4738
44. Schweizer J, Bowden PE, Coulombe PA, et al. New consensus nomenclature for mammalian keratins. J Cell Biol. 2006 ; 174: 169-174
45. Rogers MA, Langbein L, Praetzel-Wunder S, et al. Human hair keratin-associated proteins (KAPs). Int Rev Cytol. 2006 ; 251: 209-263
46. Singer AJ, Taira BR, Lin F, et al. Curcumin reduces injury progression in a rat comb burn model. J Burn Care Res. 2011 ; 32: 135-142
47. Buchanan JH. A cystine-rich protein fraction from oxidized alpha-keratin. Biochem J. 1977 ; 167: 489-491
48. Yamauchi K, Maniwa M, Mori T. Cultivation of fibroblast cells on keratin-coated substrata. J Biomater Sci Polym Ed. 1998 ; 9: 259-270
49. Tachibana A, Kaneko S, Tanabe T, et al. Rapid fabrication of keratin-hydroxyapatite hybrid sponges toward osteoblast cultivation and differentiation. Biomaterials. 2005 ; 26: 297-302
50. Sierpinski P, Garrett J, Ma J, et al. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves. Biomaterials. 2008 ; 29: 118-128
51. Shen D, Wang X, Zhang L, et al. The amelioration of cardiac dysfunction after myocardial infarction by the injection of keratin biomaterials derived from human hair. Biomaterials. 2011 ; 32: 9290-9299
52. Saul JM, Ellenburg MD, de Guzman RC, et al. Keratin hydrogels support the sustained release of bioactive ciprofloxacin. J Biomed Mater Res A. 2011 ; 98: 544-553
53. Reichl S. Films based on human hair keratin as substrates for cell culture and tissue engineering. Biomaterials. 2009 ; 30: 6854-6866
54. Pechter PM, Gil J, Valdes J, et al. Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound Repair Regen. 2012 ; 20: 236-242
55. Lee KY, Kong SJ, Park WH, et al. Effect of surface properties on the antithrombogenicity of silk fibroin/S-carboxymethyl kerateine blend films. J Biomater Sci Polym Ed. 1998 ; 9: 905-914
56. Dias GJ, Peplow PV, McLaughlin A, et al. Biocompatibility and osseointegration of reconstituted keratin in an ovine model. J Biomed Mater Res A. 2010 ; 92: 513-520
57. Dias GJ, Mahoney P, Swain M, et al. Keratin-hydroxyapatite composites: biocompatibility, osseointegration, and physical properties in an ovine model. J Biomed Mater Res A. 2010 ; 95: 1084-1095
58. Belcarz A, Ginalska G, Zalewska J, et al. Covalent coating of hydroxyapatite by keratin stabilizes gentamicin release. J Biomed Mater Res B Appl Biomater. 2009 ; 89: 102-113
59. Thilagar S, Jothi NA, Omar AR, et al. Effect of keratin-gelatin and bFGF-gelatin composite film as a sandwich layer for full-thickness skin mesh graft in experimental dogs. J Biomed Mater Res B Appl Biomater. 2009 ; 88: 12-16
60. Reichl S, Borrelli M, Geerling G. Keratin films for ocular surface reconstruction. Biomaterials. 2011 ; 32: 3375-3386
61. Hill PS, Apel PJ, Barnwell J, et al. Repair of peripheral nerve defects in rabbits using keratin hydrogel scaffolds. Tissue Eng Part A. 2011 ; 17: 1499-1505
62. de Guzman RC, Merrill MR, Richter JR, et al. Mechanical and biological properties of keratose biomaterials. Biomaterials. 2011 ; 32: 8205-8217
63. Papp A, Kiraly K, Harma M, et al. The progression of burn depth in experimental burns: a histological and methodological study. Burns. 2004 ; 30: 684-690
64. Edwards J. Hydrogels and their potential uses in burn wound management. Br J Nurs. 2010 ; 19: S4-6, S12
65. Tachibana A, Nishikawa Y, Nishino M, et al. Modified keratin sponge: binding of bone morphogenetic protein-2 and osteoblast differentiation. J Biosci Bioeng. 2006 ; 102: 425-429
66. Nunez F, Trach S, Burnett L, et al. Vasoactive properties of keratin-derived compounds. Microcirculation. 2011 ; 18: 663-669
67. Richter JR, de Guzman RC, Van Dyke ME. Mechanisms of hepatocyte attachment to keratin biomaterials. Biomaterials. 2011 ; 32: 7555-7561
68. Widra A. Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same. Patent US 4570629, USA, 1986.
69. Jackson DM. [The diagnosis of the depth of burning]. Br J Surg. 1953 ; 40: 588-596
70. Park CH, Lee MJ, Ahn J, et al. Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop. J Invest Dermatol. 2004 ; 123: 1012-1019
71. Crewther WG, Fraser RD, Lennox FG, et al. The chemistry of keratins. Adv Protein Chem. 1965 ; 20: 191-346
72. Barthelemy NR, Bednarczyk A, Schaeffer-Reiss C, et al. Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments. Anal Biochem. 2012 ; 421: 43-55
73. Vorotnikova E, McIntosh D, Dewilde A, et al. Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo. Matrix Biol. 2010 ; 29: 690-700
74. Badylak SF, Park K, Peppas N, et al. Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. Exp Hematol. 2001 ; 29: 1310-1318
75. Li F, Li W, Johnson S, et al. Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells. Endothelium. 2004 ; 11: 199-206
76. Xu J, Rodriguez D, Petitclerc E, et al. Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol. 2001 ; 154: 1069-1079
77. Honma I, Kitamura H, Torigoe T, et al. Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer. Cancer Immunol Immunother. 2009 ; 58: 1801-1807