Evaluation of chitosan gel with 1% silver sulfadiazine as an alternative for burn wound treatment in rats

Acta Cirurgica Brasileira

Volumn 24, Issue 6, 2009, Pages 460-465

  Do Nascimento, Ednaldo Gomes ^a   Sampaio, Tarcísio Bruno Montenegro ^a   Medeiros, Aldo Cunha ^b   De Azevedo, Eduardo Pereira ^a  

^a Department of Pharmacy UnP ^*  (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Chitosan; Gel; Rats; Silver sulfadiazine; Wound healing

Indexed keywords

CHITOSAN; SULFADIAZINE SILVER; GEL;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BURN; CONTROLLED STUDY; CREAM; DRUG RELEASE; FIBROBLAST; GEL; INFLAMMATION; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; RAT; WOUND CARE; WOUND HEALING; ANIMAL; ANIMAL MODEL; BURNS; CHEMISTRY; DRUG EFFECTS; FLOW KINETICS; METABOLISM; TOPICAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, TOPICAL; ANIMALS; BURNS; CHITOSAN; GELS; MALE; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; RHEOLOGY; SILVER SULFADIAZINE; WOUND HEALING;

EID: 74249118297     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502009000600007     Document Type: Article

References (16)

1. Ward RS, Saffle JR. Topical agents in burn and wound care. Phys Ther. 1995;75:526-38.
2. Robson MC, Mannari RJ, Smith PD, Payne WG. Maintenance of wound bacterial balance. Am J Surg. 1999;178:399-402.
3. Monafo WW, West MA. Current treatment recommendations for topical burn therapy. Drugs. 1990;40:364-73.
4. Azevedo EP, Saldanha TDP, Navarro MVM, Raffin FN. Mechanical properties and release studies of chitosan films impregnated with silver sulfadiazine. J Appl Polym Sci. 2006;102:3462-70.
5. Rinaudo M. Chitin and chitosan: properties and applications. Prog Polym Sci. 2006;31:603-32.
6. Prabaharan M. Review paper: chitosan derivatives as promising materials for controlled drug delivery. J Biomater Appl. 2008;23:5-36.
7. Ishihara M, Ono K, Sato M, Nakanishi K, Saito Y, Yura H. Acceleration of wound contraction and healing with a photocrosslinkable chitosan hydrogel. Wound Repair Regen. 2001;9:513-21.
8. Alemdaroglu C, Degim Z, Celebi N, Zor F, Ozturk S, Erdogan D. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns. 2006;32:319-27.
9. Modak S, Fox C. Synergistic action of silver sulfadiazina and sodium piperacillin on resistant Pseudomonas aerugionosa in vitro and in experimental burn wound infections. J Trauma. 1985;25:27-31.
10. Wang T, Turhan M, Gunasekaran S. Selected properties of pH-sensitive, biodegradable chitosan-poly(vinyl alcohol) hydrogel. Polym Int. 2004;53:911-8.
11. Sezer AD, Cevher E, Hatipoglu F, Ogurtan Z, Bas AL, Akbuga J. Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits. Biol Pharm Bull. 2008;31:2326-33.
12. Ono K, Saito Y, Yura H, Ishikawa K, Kurita A, Akaike T. Photocrosslinkable chitosan as a biological adhesive. J Biomed Mater Res. 2000;49:289-95.
13. Ueno H, Yamada H, Tanaka I, Kaba N, Matsuura M, Okumura M. Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials. 1999;20:1407-14.
14. Medeiros AC, Ramos AMO, Dantas Filho AM, Azevedo RCF, Araujo, FLFB. Tratamento tópico de queimaduras do dorso de ratos com acido hialuronico. Acta Cir Bras. 1999;14:203-7.
15. Ueno H, Nakamura F, Murakami M, Okumura M, Kadosawa T, Fujinag T. Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages. Biomaterials. 2001;22:2125-30.
16. Kjolseth D, Frank JM, Barker JH, Anderson GL, Rosenthal AI, Acland RD. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. J Am Coll Surg. 1994;179:305-12.