Chitosan acetate bandage as a topical antimicrobial dressing for infected burns

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 2, 2009, Pages 393-400

  Dai, Tianhong ^a,b   Tegos, George P ^a,b   Burkatovskaya, Marina ^a   Castano, Ana P ^a,b   Hamblin, Michael R ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; CHITOSAN ACETATE; CHITOSAN DERIVATIVE; SILVER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL TRANSMISSION; BURN INFECTION; CONTROLLED STUDY; FEMALE; GRAM NEGATIVE SEPSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PSEUDOMONAS MIRABILIS; SURVIVAL RATE; WOUND DRESSING;

EID: 59749097641     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00760-08     Document Type: Article

References (44)

1. Aksungur, P., A. Sungur, S. Unal, A. B. Iskit, C. A. Squier, and S. Senel. 2004. Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies. J. Control. Release 98:269-279.
2. Azad, A. K., N. Sermsintham, S. Chandrkrachang, and W. F. Stevens. 2004. Chitosan membrane as a wound-healing dressing: characterization and clinical application. J. Biomed. Mater. Res. B Appl. Biomater. 69:216-222.
3. Burkatovskaya, M., A. P. Castano, T. N. Demidova-Rice, G. P. Tegos, and M. R. Hamblin. 2008. Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice. Wound Repair Regen. 16:425-431.
4. Burkatovskaya, M., G. P. Tegos, E. Swietlik, T. N. Demidova, A. P. Castano, and M. R. Hamblin. 2006. Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials 27:4157-4164.
5. Church, D., S. Elsayed, O. Reid, B. Winston, and R. Lindsay. 2006. Burn wound infections. Clin. Microbiol. Rev. 19:403-434.
6. Dale, R. M., G. Schnell, and J. P. Wong. 2004. Therapeutic efficacy of "nubiotics" against burn wound infection by Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 48:2918-2923.
7. Demidova, T. N., F. Gad, T. Zahra, K. P. Francis, and M. R. Hamblin. 2005. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J. Photochem. Photobiol. B 81:15-25.
8. Di Martino, A., M. Sittinger, and M. V. Risbud. 2005. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26:5983-5990.
9. Doyle, T. C., S. M. Burns, and C. H. Contag. 2004. In vivo bioluminescence imaging for integrated studies of infection. Cell. Microbiol. 6:303-317.
10. Eaves-Pyles, T., and J. W. Alexander. 2001. Comparison of translocation of different types of microorganisms from the intestinal tract of burned mice. Shock 16:148-152.
11. Foweraker, J. E., C. R. Laughton, D. F. Brown, and D. Bilton. 2005. Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing. J. Antimicrob. Chemother. 55:921-927.
12. Gianotti, L., J. W. Alexander, T. Pyles, L. James, and G. F. Babcock. 1993. Relationship between extent of burn injury and magnitude of microbial translocation from the intestine. J. Burn Care Rehabil. 14:336-342.
13. Gilpin, D. A. 1996. Calculation of a new Meeh constant and experimental determination of burn size. Burns 22:607-611.
14. Greenfield, E., and A. T. McManus. 1997. Infectious complications: prevention and strategies for their control. Nurs. Clin. N. Am. 32:297-309.
15. Ha, U., and S. Jin. 1999. Expression of the soxR gene of Pseudomonas aeruginosa is inducible during infection of burn wounds in mice and is required to cause efficient bacteremia. Infect. Immun. 67:5324-5331.
16. Hamblin, M. R., D. A. O'Donnell, N. Murthy, C. H. Contag, and T. Hasan. 2002. Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem. Photobiol. 75: 51-57.
17. Harrison, J. W., and T. A. Svec. 1998. The beginning of the end of the antibiotic era? Part I. The problem: abuse of the "miracle drugs." Quintessence Int. 29:151-162.
18. Harshey, R. M. 1994. Bees aren't the only ones: swarming in gram-negative bacteria. Mol. Microbiol. 13:389-394.
19. Holder, I. A., and A. N. Neely. 1989. Pseudomonas elastase acts as a virulence factor in burned hosts by Hageman factor-dependent activation of the host kinin cascade. Infect. Immun. 57:3345-3348.
20. Ip, M., S. L. Lui, V. K. Poon, I. Lung, and A. Burd. 2006. Antimicrobial activities of silver dressings: an in vitro comparison. J. Med. Microbiol. 55:59-63.
21. Kheirabadi, B. S., E. M. Acheson, R. Deguzman, J. L. Sondeen, K. L. Ryan, A. Delgado, E. J. Dick, Jr., and J. B. Holcomb. 2005. Hemostatic efficacy of two advanced dressings in an aortic hemorrhage model in swine. J. Trauma 59:25-34.
22. Kumar, M. N., R. A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A. J. Domb. 2004. Chitosan chemistry and pharmaceutical perspectives. Chem. Rev. 104: 6017-6084.
23. Liu, H., Y. Du, X. Wang, and L. Sun. 2004. Chitosan kills bacteria through cell membrane damage. Int. J. Food Microbiol. 95:147-155.
24. Manson, W. L., J. M. Coenen, H. J. Klasen, and E. H. Horwitz. 1992. Intestinal bacterial translocation in experimentally burned mice with wounds colonized by Pseudomonas aeruginosa. J. Trauma 33:654-658.
25. Markley, K., and E. Smallman. 1968. Protection by vaccination against Pseudomonas infection after thermal injury. J. Bacteriol. 96:867-874.
26. McManus, A. T., C. G. McLeod, Jr., and A. D. Mason, Jr. 1982. Experimental Proteus mirabilis burn surface infection. Arch. Surg. 117:187-191.
27. Mobley, H. L., and R. Belas. 1995. Swarming and pathogenicity of Proteus mirabilis in the urinary tract. Trends Microbiol. 3:280-284.
28. Murray, C. K. 2007. Infections in burns. J. Trauma 62:S73.
29. Neely, A. N., I. A. Holder, and G. D. Warden. 1999. Then and now: studies using a burned mouse model reflect trends in burn research over the past 25 years. Burns 25:603-609.
30. Neely, A. N., R. G. Miller, and I. A. Holder. 1994. Proteolytic activity and fatal gram-negative sepsis in burned mice: effect of exogenous proteinase inhibition. Infect. Immun. 62:2158-2164.
31. Neuffer, M. C., J. McDivitt, D. Rose, K. King, C. C. Cloonan, and J. S. Vayer. 2004. Hemostatic dressings for the first responder: a review. Mil. Med. 169:716-720.
32. Pavlovskis, O. R., and B. Wretlind. 1979. Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection. Infect. Immun. 24:181-187.
33. Poole, M. D. 1993. Are we facing the end of the antibiotic era? Ear Nose Throat J. 72:433.
34. Pusateri, A. E., S. J. McCarthy, K. W. Gregory, R. A. Harris, L. Cardenas, A. T. McManus, and C. W. Goodwin, Jr. 2003. Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. J. Trauma 54:177-182.
35. Rabea, E. I., M. E. Badawy, C. V. Stevens, G. Smagghe, and W. Steurbaut. 2003. Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules 4:1457-1465.
36. Rocchetta, H. L., C. J. Boylan, J. W. Foley, P. W. Iversen, D. L. LeTourneau, C. L. McMillian, P. R. Contag, D. E. Jenkins, and T. R. Parr, Jr. 2001. Validation of a noninvasive, real-time imaging technology using bioluminescent Escherichia coli in the neutropenic mouse thigh model of infection. Antimicrob. Agents Chemother. 45:129-137.
37. Rosenthal, S. M. 1967. Local and systemic therapy of Pseudomonas septicemia in burned mice. Ann. Surg. 165:97-103.
38. Stevens, E. J., C. M. Ryan, J. S. Friedberg, R. L. Barnhill, M. L. Yarmush, and R. G. Tompkins. 1994. A quantitative model of invasive Pseudomonas infection in burn injury. J. Burn Care Rehabil. 15:232-235.
39. Stevenson, J. M., R. L. Gamelli, and R. Shankar. 2003. A mouse model of burn wounding and sepsis. Methods Mol. Med. 78:95-105.
40. Walker, H. L., A. D. Mason, Jr., and G. L. Raulston. 1964. Surface infection with Pseudomonas aeruginosa. Ann. Surg. 160:297-305.
41. Webb, J. S., M. Lau, and S. Kjelleberg. 2004. Bacteriophage and phenotypic variation in Pseudomonas aeruginosa biofilm development. J. Bacteriol. 186: 8066-8073.
42. Wedmore, I., J. G. McManus, A. E. Pusateri, and J. B. Holcomb. 2006. A special report on the chitosan-based hemostatic dressing: experience in current combat operations. J. Trauma 60:655-658.
43. Yagci, A., Y. Tuc, and G. Soyletir. 2002. Elastase and alkaline protease production by Pseudomonas aeruginosa strains: comparison of two procedures. New Microbiol. 25:223-229.
44. Yilmaz, E. 2004. Chitosan: a versatile biomaterial. Adv. Exp. Med. Biol. 553:59-68.