Biocompatibility and osseointegration of reconstituted keratin in an ovine model

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 2, 2010, Pages 513-520

  Dias, George J ^a   Peplow, Philip V ^a   McLaughlin, Andrew ^a   Teixeira, Fernanda ^a,c   Kelly, Robert J ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b Keratec Limited   (New Zealand)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Bone grafts; Osseointegration; Polymeric implants; Reconstituted keratin; Sheep model

Indexed keywords

ACIDIC TREATMENT; BIODEGRADATION RATE; BONE FORMATION; BONE GRAFT; IMPLANT SURFACE; IN-VIVO; INERT MATERIALS; ORTHOPAEDIC APPLICATIONS; OSSEOINTEGRATION; OVINE MODEL; POLYMERIC IMPLANTS; SHEEP MODEL; SHORT DISTANCES; TIME POINTS; TISSUE REACTIONS;

BIOCOMPATIBILITY; BIODEGRADATION; HYDROXYAPATITE; SOIL MECHANICS; WOOL;

BONE;

HYDROXYAPATITE; KERATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; BONE DEFECT; BONE REGENERATION; CONTROLLED STUDY; FEMALE; FEMUR DEFECT; GRANULATION TISSUE; HISTOPATHOLOGY; IMPLANT; NONHUMAN; ORTHOPEDIC SURGERY; OSSIFICATION; SHEEP; TIBIA DEFECT;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; DURAPATITE; FEMALE; FEMUR; HYDROGEN-ION CONCENTRATION; KERATINS; MATERIALS TESTING; PARTICLE SIZE; POROSITY; SHEEP; TIBIA;

EID: 75149148021     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32394     Document Type: Article

References (26)

1. Stevens MM. Biomaterials for bone tissue engineering. Materials Today 2008;11:18-25.
2. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT. Tissue engineering of bone: Material and matrix considerations. J Bone Joint Surg Am 2008;90(Suppl 1):36-42.
3. Nagels J, Stokdijk M, Rozing PM. Stress shielding and bone resorption in shoulder arthroplasty. J Shoulder Elbow Surg 2003;12:35-39.
4. Bergsma JE, de Bruijn WC, Rozema FR, Bos RR, Boering G. Late degradation tissue response to poly(L-lactide) bone plates and screws. Biomaterials 1995;16:25-31.
5. Bostman O, Paivarinta U, Partio E, Vasenius J, Manninen MPR. Degradation and tissue replacement of an absorbable polyglycolide screw in the fixation of rabbit femoral osteotomies. J Bone Joint Surg Am 1992;74:1021-1031.
6. Suuronen R, Pohjonen T, Hietanen J, Lindqvist C. A 5-year in vitro and in vivo study of the biodegradation of polylactide plates. J Oral Maxillofac Surg 1998;56:604-614.
7. Leupold JA, Barfield WR, An YH, Hartsock LA. A comparison of ProOsteon, DBX, and collagraft in a rabbit model. J Biomed Mater Res B Appl Biomater 2006;79B:292-297.
8. Surgicel. Johnson & Johnson. Absorbable Hemostat, Oxidated Regenerated Cellulose. New Brunswick, NJ: Surgicel. Johnson & Johnson; 1980.
9. Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials 2006;27:1728-1734.
10. Feughelmann M. Keratin. In: Kroschwitz JI, editor. Encyclopedia of Polymer Science and Engineering. New York: Wiley; 1985. p 566-600.
11. Dowling LM, Crewther WG, Parry DA. Secondary structure of component 8c-1 of alpha-keratin. An analysis of the amino acid sequence. Biochem J 1986;236:705-712.
12. Yamauchi K, Yamauchi A, Kusunoki T, Kohda A, Konishi Y. Preparation of stable aqueous solution of keratins, and physiochemical and biodegradational properties of films. J Biomed Mater Res 1996;31:439-444.
13. Yamauchi K, Maniwa M, Mori T. Cultivation of fibroblast cells on keratin-coated substrata. J Biomater Sci Polym Ed 1998;9:259-270.
14. Tanabe T, Okitsu N, Tachibana A, Yamauchi K. Preparation and characterization of keratin-chitosan composite film. Biomaterials 2002;23:817-825.
15. Peplow PV, Dias GJ. A study of the relationship between mass and physical strength of keratin bars in vivo. J Mater Sci Mater Med 2004;1:1217-1220.
16. Tanabe T, Tachibana A, Yamauchi K. Keratins: Prospective proteinous biomaterial. Recent Res Dev Protein Eng 2001;1: 247-259.
17. Heimann RB, Schurmann N, Muller RT. In vitro and in vivo performance of Ti6Al4V implants with plasma-sprayed osteoconductive hydroxylapatite-bioinert titania bond coat "duplex" systems: An experimental study in sheep. J Mater Sci Mater Med 2004;15:1045-1052.
18. Kontio R, Suuronen R, Konttinen YT, Hallikainen D, Lindqvist C, Kommonen B, Kellomaki M, Kylma T, Virtanen I, Laine P. Orbital floor reconstruction with poly-l/d-lactide implants: Clinical, radiological and immunohistochemical study in sheep. Int J Oral Maxillofac Surg 2004;33:361-368.
19. Willie BM, Bloebaum RD, Bireley WR, Bachus KN, Hofmann AA. Determining relevance of a weight-bearing ovine model for bone ingrowth assessment. J Biomed Mater Res A 2004; 69:567-576.
20. Ignatius A, Peraus M, Schorlemmer S, Augat P, Burger W, Leyen S, Claes L. Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions. Biomaterials 2005;26:2325-2332.
21. Kelly RJ, Roddick-Lanzilotta AD, Dias GJ, Peplow PV. Orthopaedic materials derived from keratin. New Zealand Patent PCT/NZ03/00116, 2004.
22. Dias GJ, Peplow PV, Teixeira F. Osseous regeneration in the presence of oxidized cellulose and collagen. J Mater Sci Mater Med 2003;14:739-745.
23. Chambers T. The response of the macrophage to foreign material. In: Williams D, editor. Fundamental Aspects of Biocompatibility. Florida: CRC Press Inc., Boca Raton; 1981. p145-158.
24. Meachim G, Pedley R. The tissue response at implant sites. In: Williams D, editor. Fundamental Aspects of Biocompatibility. Florida: CRC Press Inc., Boca Raton; 1981. p 107-144.
25. Nam YS, Park TG. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J Biomed Mater Res 1999;47:8-17.
26. Bostman O, Pihlajamaki H. Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: A review. Biomaterials 2000;21:2615-2621.