Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Hossain, Mohammad S ^a   Ramachandiran, Sampath ^a   Gewirtz, Andrew T ^b   Waller, Edmund K ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENTOLIMOD; GAMMA INTERFERON; GRANZYME B; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; CYTOKINE; FLAGELLIN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY A; PEPTIDE; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG BINDING; DRUG MECHANISM; GRAFT VERSUS HOST REACTION; IMMUNOREGULATION; LETHALITY; LIVER; LYMPHOCYTE DEPLETION; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; SINGLE DRUG DOSE; VIRUS LOAD; AGONISTS; ANIMAL; C57BL MOUSE; CELL COUNT; CYTOLOGY; CYTOMEGALOVIRUS; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; TIME;

ANIMALS; CELL COUNT; CYTOKINES; CYTOMEGALOVIRUS; FLAGELLIN; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY A; PEPTIDES; RECOMBINANT PROTEINS; TIME FACTORS; TOLL-LIKE RECEPTOR 5;

EID: 84902326195     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096165     Document Type: Article

References (46)

1. Paar DP, Pollard RB (1996) Immunotherapy of CMV infections. Advances in experimental medicine and biology 394: 145-151. (Pubitemid 26139742)
2. Nomura F, Shimokata K, Sakai S, Yamauchi T, Kodera Y, et al. (1990) Cytomegalovirus pneumonitis occurring after allogeneic bone marrow transplantation: a study of 106 recipients. Japanese journal of medicine 29: 595-602.
3. Langston AA, Redei I, Caliendo AM, Somani J, Hutcherson D, et al. (2002) Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation. Blood 99: 1085-1088. (Pubitemid 34525576)
4. Lenac T, Arapovic J, Traven L, Krmpotic A, Jonjic S (2008) Murine cytomegalovirus regulation of NKG2D ligands. Med Microbiol Immunol 197: 159-166.
5. Babic M, Krmpotic A, Jonjic S (2011) All is fair in virus-host interactions: NK cells and cytomegalovirus. Trends Mol Med 17: 677-685.
6. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America 101: 3516-3521. (Pubitemid 38338227)
7. Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, et al. (2005) Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. Journal of leukocyte biology 78: 888-897. (Pubitemid 41384405)
8. Hossain MS, Jaye DL, Pollack BP, Farris AB, Tselanyane ML, et al. (2011) Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. Journal of immunology 187: 5130-5140.
9. Zeng H, Wu H, Sloane V, Jones R, Yu Y, et al. (2006) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American journal of physiology Gastrointestinal and liver physiology 290: G96-G108.
10. Salamone GV, Petracca Y, Fuxman Bass JI, Rumbo M, Nahmod KA, et al. (2010) Flagellin delays spontaneous human neutrophil apoptosis. Lab Invest 90: 1049-1059.
11. Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG (2005) Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nat Med 11: 1299-1305. (Pubitemid 41752910)
12. Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG (2005) Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease. J Immunol 174: 3051-3058. (Pubitemid 40279726)
13. Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, et al. (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320: 226-230. (Pubitemid 351521417)
14. Eaves-Pyles T, Murthy K, Liaudet L, Virag L, Ross G, et al. (2001) Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. Journal of immunology 166: 1248-1260. (Pubitemid 32060286)
15. Brautigam AR, Dutko FJ, Olding LB, Oldstone MB (1979) Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency. The Journal of general virology 44: 349-359. (Pubitemid 10234769)
16. Dalod M, Hamilton T, Salomon R, Salazar-Mather TP, Henry SC, et al. (2003) Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. The Journal of experimental medicine 197: 885-898. (Pubitemid 36437865)
17. Biron CA, Su HC, Orange JS (1996) Function and Regulation of Natural Killer (NK) Cells during Viral Infections: Characterization of Responses in Vivo. Methods 9: 379-393. (Pubitemid 26179436)
18. Vahlne G, Becker S, Brodin P, Johansson MH (2008) IFN-gamma production and degranulation are differentially regulated in response to stimulation in murine natural killer cells. Scand J Immunol 67: 1-11. (Pubitemid 350209577)
19. Lanier LL (2008) Up on the tightrope: natural killer cell activation and inhibition. Nature immunology 9: 495-502.
20. Li JM, Southerland L, Hossain MS, Giver CR, Wang Y, et al. (2011) Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice. Journal of immunology 187: 1057-1065.
21. Wu X, Chen Y, Wei H, Sun R, Tian Z (2012) Development of murine hepatic NK cells during ontogeny: comparison with spleen NK cells. Clinical & developmental immunology 2012: 759765.
22. Pyzik M, Gendron-Pontbriand EM, Vidal SM (2011) The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses. Journal of biomedicine & biotechnology 2011: 641702.
23. Daeron M, Latour S, Malbec O, Espinosa E, Pina P, et al. (1995) The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 3: 635-646.
24. Huntington ND, Tabarias H, Fairfax K, Brady J, Hayakawa Y, et al. (2007) NK cell maturation and peripheral homeostasis is associated with KLRG1 upregulation. Journal of immunology 178: 4764-4770. (Pubitemid 46595257)
25. Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, et al. (2012) Structural basis of TLR5-flagellin recognition and signaling. Science 335: 859-864.
26. Hossain MS, Takimoto H, Hamano S, Yoshida H, Ninomiya T, et al. (1999) Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. Immunopharmacology 41: 169-181. (Pubitemid 29243819)
27. Lauzon NM, Mian F, MacKenzie R, Ashkar AA (2006) The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity. Cell Immunol 241: 102-112. (Pubitemid 44648026)
28. Li JM, Hossain MS, Southerland L, Waller EK (2013) Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients. Blood 121: 2347-2351.
29. Salem ML, Hossain MS (2000) Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International journal of immunopharmacology 22: 729-740. (Pubitemid 30407026)
30. Chiossone L, Chaix J, Fuseri N, Roth C, Vivier E, et al. (2009) Maturation of mouse NK cells is a 4-stage developmental program. Blood 113: 5488-5496.
31. Fu B, Wang F, Sun R, Ling B, Tian Z, et al. (2011) CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells. Immunology 133: 350-359.
32. Kim S, Iizuka K, Kang HS, Dokun A, French AR, et al. (2002) In vivo developmental stages in murine natural killer cell maturation. Nature immunology 3: 523-528. (Pubitemid 34662303)
33. Orange JS, Biron CA (1996) Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. Journal of immunology 156: 4746-4756. (Pubitemid 26174459)
34. Orange JS, Biron CA (1996) An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. Journal of immunology 156: 1138-1142.
35. Alter G, Malenfant JM, Altfeld M (2004) CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 294: 15-22. (Pubitemid 39626587)
36. Graubardt N, Fahrner R, Trochsler M, Keogh A, Breu K, et al. (2013) Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis. Hepatology 57: 1969-1979.
37. Biron CA (1997) Activation and function of natural killer cell responses during viral infections. Current opinion in immunology 9: 24-34.
38. Biron CA (1998) Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Seminars in immunology 10: 383-390.
39. Honko AN, Mizel SB (2005) Effects of flagellin on innate and adaptive immunity. Immunologic research 33: 83-101. (Pubitemid 41266860)
40. Kofoed EM, Vance RE (2012) NAIPs: building an innate immune barrier against bacterial pathogens. NAIPs function as sensors that initiate innate immunity by detection of bacterial proteins in the host cell cytosol. BioEssays : news and reviews in molecular, cellular and developmental biology 34: 589-598.
41. Dokun AO, Kim S, Smith HR, Kang HS, Chu DT, et al. (2001) Specific and nonspecific NK cell activation during virus infection. Nature immunology 2: 951-956. (Pubitemid 32976168)
42. Tanaka J, Imamura M, Kasai M, Sakurada K (1995) Transplantation-related complications predicted by cytokine gene expression in the mixed lymphocyte culture in allogeneic bone marrow transplants. Leukemia & lymphoma 19: 27-32.
43. Ohta M, Tateishi K, Kanai F, Ueha S, Guleng B, et al. (2005) Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice. European journal of immunology 35: 2210-2221. (Pubitemid 41015060)
44. Antin JH, Ferrara JL (1992) Cytokine dysregulation and acute graft-versus-host disease. Blood 80: 2964-2968. (Pubitemid 23004498)
45. Hokland M, Jacobsen N, Ellegaard J, Hokland P (1988) Natural killer function following allogeneic bone marrow transplantation. Very early reemergence but strong dependence of cytomegalovirus infection. Transplantation 45: 1080-1084.
46. Ding X, Bian G, Leigh ND, Qiu J, McCarthy PL, et al. (2012) A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease. Journal of immunology 189: 4719-4727.