-
1
-
-
66149104271
-
Angiotensin ii activates i kappab kinase phosphorylation of RelA at ser 536 to promote myofibroblast survival and liver fibrosis
-
Oakley F, Teoh V, Ching ASG, et al. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 2009;136:2334-44 e1.
-
(2009)
Gastroenterology
, vol.136
, pp. 2334-2344
-
-
Oakley, F.1
Teoh, V.2
Ching, A.S.G.3
-
2
-
-
72249114470
-
Modulation of hepatic fibrosis by c-jun-n-terminal kinase inhibition
-
Kluwe J, Pradere JP, Gwak GY, et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 2010;138:347-59.
-
(2010)
Gastroenterology
, vol.138
, pp. 347-359
-
-
Kluwe, J.1
Pradere, J.P.2
Gwak, G.Y.3
-
3
-
-
33847363203
-
Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
DOI 10.1172/JCI30542
-
Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117:539-48. (Pubitemid 46348508)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 539-548
-
-
Iredale, J.P.1
-
4
-
-
42949163491
-
Mechanisms of Hepatic Fibrogenesis
-
DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
-
Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;134:1655-69. (Pubitemid 351615417)
-
(2008)
Gastroenterology
, vol.134
, Issue.6
, pp. 1655-1669
-
-
Friedman, S.L.1
-
5
-
-
35948954244
-
Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
-
Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008;88:125-72.
-
(2008)
Physiol Rev
, vol.88
, pp. 125-172
-
-
Friedman, S.L.1
-
6
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-52.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
7
-
-
20244376914
-
Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury
-
Yoshida K, Matsuzaki K, Mori S, et al. Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol 2005;166:1029-39. (Pubitemid 40524428)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.4
, pp. 1029-1039
-
-
Yoshida, K.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yamagata, H.5
Furukawa, F.6
Seki, T.7
Nishizawa, M.8
Fujisawa, J.9
Okazaki, K.10
-
8
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase
-
DOI 10.1074/jbc.274.1.305
-
Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-15. (Pubitemid 29035064)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.1
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
9
-
-
35648935982
-
Suppression of p53-dependent senescence by the JNK signal transduction pathway
-
DOI 10.1073/pnas.0707782104
-
Das M, Jiang F, Sluss HK, et al. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 2007;104:15759-64. (Pubitemid 350035373)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.40
, pp. 15759-15764
-
-
Das, M.1
Jiang, F.2
Sluss, H.K.3
Zhang, C.4
Shokat, K.M.5
Flavell, R.A.6
Davis, R.J.7
-
10
-
-
0032509479
-
Defective T cell differentiation in the absence of Jnk1
-
DOI 10.1126/science.282.5396.2092
-
Dong C, Yang DD, Wysk M, et al. Defective T cell differentiation in the absence of Jnk1. Science 1998;282:2092-5. (Pubitemid 29001267)
-
(1998)
Science
, vol.282
, Issue.5396
, pp. 2092-2095
-
-
Dong, C.1
Yang, D.D.2
Wysk, M.3
Whitmarsh, A.J.4
Davis, R.J.5
Flavell, R.A.6
-
11
-
-
84864198388
-
A liver full of JNK: Signaling in regulation of cell function and disease pathogenesis, and clinical approaches
-
Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology 2012;143:307-20.
-
(2012)
Gastroenterology
, vol.143
, pp. 307-320
-
-
Seki, E.1
Brenner, D.A.2
Karin, M.3
-
12
-
-
4043154985
-
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease
-
DOI 10.1002/hep.20277
-
Toivola DM, Ku NO, Resurreccion EZ, et al. Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology 2004;40:459-66. (Pubitemid 39062864)
-
(2004)
Hepatology
, vol.40
, Issue.2
, pp. 459-466
-
-
Toivola, D.M.1
Ku, N.-O.2
Resurreccion, E.Z.3
Nelson, D.R.4
Wright, T.L.5
Omary, M.B.6
-
13
-
-
17344371807
-
Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
-
Louis H, Van Laethem JL, Wu W, et al. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 1998;28:1607-15. (Pubitemid 28549131)
-
(1998)
Hepatology
, vol.28
, Issue.6
, pp. 1607-1615
-
-
Louis, H.1
Van Laethem, J.-L.2
Wu, W.3
Quertinmont, E.4
Degraef, C.5
Van Den Berg, K.6
Demols, A.7
Goldman, M.8
Le Moine, O.9
Geerts, A.10
Deviere, J.11
-
14
-
-
83455259787
-
Update on hepatic stellate cells: Pathogenic role in liver fibrosis and novel isolation techniques
-
Tacke F, Weiskirchen R. Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. Expert Rev Gastroenterol Hepatol 2012;6:67-80.
-
(2012)
Expert Rev Gastroenterol Hepatol
, vol.6
, pp. 67-80
-
-
Tacke, F.1
Weiskirchen, R.2
-
17
-
-
58249093873
-
Induction of hepatitis by JNK-mediated expression of TNF-alpha
-
Das M, Sabio G, Jiang F, et al. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 2009;136:249-60.
-
(2009)
Cell
, vol.136
, pp. 249-260
-
-
Das, M.1
Sabio, G.2
Jiang, F.3
-
18
-
-
33645799492
-
Mechanisms of liver injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
-
Schwabe RF, Brenner DA. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G583-9.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Schwabe, R.F.1
Brenner, D.A.2
-
19
-
-
53149111140
-
Differential roles of JNK in conA/galN and conA-induced liver injury in mice
-
Ni HM, Chen X, Ding WX, et al. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 2008;173:962-72.
-
(2008)
Am J Pathol
, vol.173
, pp. 962-972
-
-
Ni, H.M.1
Chen, X.2
Ding, W.X.3
-
21
-
-
32044447161
-
L turnover
-
DOI 10.1016/j.cell.2006.01.021, PII S0092867406001139
-
Chang L, Kamata H, Solinas G, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006;124:601-13. (Pubitemid 43199444)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 601-613
-
-
Chang, L.1
Kamata, H.2
Solinas, G.3
Luo, J.-L.4
Maeda, S.5
Venuprasad, K.6
Liu, Y.-C.7
Karin, M.8
-
22
-
-
33644813043
-
JNK1 but not JNK2 promotes the development of steatohepatitis in mice
-
DOI 10.1002/hep.20999
-
Schattenberg JM, Singh R, Wang Y, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 2006;43:163-72. (Pubitemid 43733603)
-
(2006)
Hepatology
, vol.43
, Issue.1
, pp. 163-172
-
-
Schattenberg, J.M.1
Singh, R.2
Wang, Y.3
Lefkowitch, J.H.4
Rigoli, R.M.5
Scherer, P.E.6
Czaja, M.J.7
-
23
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
abio G, Cavanagh-Kyros J, Ko HJ, et al. Prevention of steatosis by hepatic JNK1. Cell Metab 2009;10:491-8.
-
(2009)
Cell Metab
, vol.10
, pp. 491-498
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Ko, H.J.3
-
24
-
-
57449109370
-
Proliferation of human HCC cells and chemically induced mouse liver cancers requires jnk1-dependent p21 downregulation
-
Hui L, Zatloukal K, Scheuch H, et al. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008;118:3943-53.
-
(2008)
J Clin Invest
, vol.118
, pp. 3943-3953
-
-
Hui, L.1
Zatloukal, K.2
Scheuch, H.3
-
25
-
-
0035889252
-
Induction of gadd4β by NF-κB downregulates pro-apoptotic JNK signalling
-
DOI 10.1038/35104560
-
De Smaele E, Zazzeroni F, Papa S, et al. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature 2001;414:308-13. (Pubitemid 33097807)
-
(2001)
Nature
, vol.414
, Issue.6861
, pp. 308-313
-
-
De Smaele, E.1
Zazzeroni, F.2
Papa, S.3
Nguyen, D.U.4
Jin, R.5
Jones, J.6
Cong, R.7
Franzoso, G.8
-
26
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
DOI 10.1016/S0092-8674(00)80085-9
-
Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147-57. (Pubitemid 26256586)
-
(1996)
Cell
, vol.86
, Issue.1
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
27
-
-
0031013545
-
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway
-
Natoli G, Costanzo A, Ianni A, et al. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 1997;275:200-3.
-
(1997)
Science
, vol.275
, pp. 200-203
-
-
Natoli, G.1
Costanzo, A.2
Ianni, A.3
-
28
-
-
0035891320
-
Inhibition of JNK activation through NF-κB target genes
-
DOI 10.1038/35104568
-
Tang G, Minemoto Y, Dibling B, et al. Inhibition of JNK activation through NF-kappaB target genes. Nature 2001;414:313-7. (Pubitemid 33097808)
-
(2001)
Nature
, vol.414
, Issue.6861
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
29
-
-
34047269946
-
Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner
-
DOI 10.1074/jbc.M606167200
-
Wicovsky A, Muller N, Daryab N, et al. Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner. J Biol Chem 2007;282:2174-83. (Pubitemid 47076782)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.4
, pp. 2174-2183
-
-
Wicovsky, A.1
Muller, N.2
Daryab, N.3
Marienfeld, R.4
Kneitz, C.5
Kavuri, S.6
Leverkus, M.7
Baumann, B.8
Wajant, H.9
-
30
-
-
0035374998
-
Transient activation of jun n-terminal kinases and protection from apoptosis by the insulin-like growth factor i receptor can be suppressed by dicumarol
-
Krause D, Lyons A, Fennelly C, et al. Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol. J Biol Chem 2001;276:19244-52.
-
(2001)
J Biol Chem
, vol.276
, pp. 19244-19252
-
-
Krause, D.1
Lyons, A.2
Fennelly, C.3
-
31
-
-
63349085077
-
C-jun n-terminal kinase 1 is required for the development of pulmonary fibrosis
-
Alcorn JF, van der Velden J, Brown AL, et al. c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis. Am J Respir Cell Mol Biol 2009;40:422-32.
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, pp. 422-432
-
-
Alcorn, J.F.1
Van Der Velden, J.2
Brown, A.L.3
-
32
-
-
33846689276
-
A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis
-
DOI 10.1681/ASN.2006060604
-
Ma FY, Flanc RS, Tesch GH, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol 2007;18:472-84. (Pubitemid 46193313)
-
(2007)
Journal of the American Society of Nephrology
, vol.18
, Issue.2
, pp. 472-484
-
-
Ma, F.Y.1
Flanc, R.S.2
Tesch, G.H.3
Han, Y.4
Atkins, R.C.5
Bennett, B.L.6
Friedman, G.C.7
Fan, J.-H.8
Nikolic-Paterson, D.J.9
-
33
-
-
35548943962
-
JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity
-
DOI 10.1016/j.cmet.2007.09.011, PII S1550413107002926
-
Solinas G, Vilcu C, Neels JG, et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab 2007;6:386-97. (Pubitemid 350012000)
-
(2007)
Cell Metabolism
, vol.6
, Issue.5
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.-L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
Karin, M.11
-
34
-
-
70349416501
-
C-jun n-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice
-
e5
-
Kodama Y, Kisseleva T, Iwaisako K, et al. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 2009;137:1467-77 e5.
-
(2009)
Gastroenterology
, vol.137
, pp. 1467-1477
-
-
Kodama, Y.1
Kisseleva, T.2
Iwaisako, K.3
-
35
-
-
79961010787
-
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice
-
Kodama T, Takehara T, Hikita H, et al. Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J Clin Invest 2011;121:3343-56.
-
(2011)
J Clin Invest
, vol.121
, pp. 3343-3356
-
-
Kodama, T.1
Takehara, T.2
Hikita, H.3
-
36
-
-
84865554746
-
Cyclin e1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice
-
Nevzorova YA, Bangen JM, Hu W, et al. Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice. Hepatology 2012;56:1140-9.
-
(2012)
Hepatology
, vol.56
, pp. 1140-1149
-
-
Nevzorova, Y.A.1
Bangen, J.M.2
Hu, W.3
|