Determination of irinotecan and its metabolite SN-38 in rabbit plasma and tumors using a validated method of tandem mass spectrometry coupled with liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 962, Issue , 2014, Pages 147-152

  Park, Dae J ^a   Won, Jun H ^a   Cho, A R ^a   Yun, Hye J ^a   Heo, Jeong H ^a   Hwhang, Tae H ^b   Lee, Dae H ^a   Kim, Woo M ^a  

^a Kosin University   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

Camptothecin; Irinotecan; LC MS MS; Rabbit; SN 38; VX2 tumor

Indexed keywords

BODY FLUIDS; CARBOXYLATION; ESTERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CAMPTOTHECIN (CPT); IRINOTECAN; LC-MS/MS; RABBIT; SN-38; VX2 TUMOR;

TUMORS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIA; CAMPTOTHECIN; ETHER; FIRTECAN; FORMIC ACID; IRINOTECAN; LACTONE; ANTINEOPLASTIC AGENT;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HYDROPHILICITY; IONIZATION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RABBIT; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CAMPTOTHECA; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; NEOPLASMS; PROCEDURES; REPRODUCIBILITY; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECA; CAMPTOTHECIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIMIT OF DETECTION; NEOPLASMS; RABBITS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84902289393     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.05.042     Document Type: Article

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