Simple non-ion-paired high-performance liquid chromatographic method for simultaneous quantitation of carboxylate and lactone forms of 14 new camptothecin derivatives

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 795, Issue 1, 2003, Pages 25-34

  Sano, Kazumi ^a   Yoshikawa, Megumi ^a   Hayasaka, Shinya ^a   Satake, Kurita ^a   Ikegami, Yoji ^a   Yoshida, Hisahiro ^a   Ishikawa, Toshihisa ^b   Sawada, Seigo ^c   Tanabe, Shinzo ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Camptothecin; CPT 11; Derivatization, LC; SN 38

Indexed keywords

DRUG DOSAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; ORGANIC COMPOUNDS; TUMORS;

DERIVATIVE SYNTHESIS;

BIOMEDICAL ENGINEERING;

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYLCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBOXYLIC ACID; LACTONE; SN 343; SN 348; SN 349; SN 351; SN 352; SN 353; SN 355; SN 364; SN 392; SN 397; SN 398; SN 443; SN 444; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG ACCUMULATION; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LINEAR SYSTEM; PRIORITY JOURNAL;

EID: 0142106518     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00485-9     Document Type: Article

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