Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27

Acta Pharmacologica Sinica

Volumn 35, Issue 6, 2014, Pages 832-838

  Sang, Dong Ping ^a,b   Li, Ru Jun ^a   Lan, Qing ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b Changshu City Chinese Medicine Hospital   (China)

Author keywords

apoptosis; caspase 3; chemotherapy; Glioma; heat shock protein 27; quercetin; RNA interference; temozolomide

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 27; QUERCETIN; TEMOZOLOMIDE; ALKYLATING AGENT; DACARBAZINE;

APOPTOSIS; ARTICLE; CELL VIABILITY; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN NEOPLASMS; DRUG EFFECTS; GLIOBLASTOMA; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; DACARBAZINE; GLIOBLASTOMA; HSP27 HEAT-SHOCK PROTEINS; HUMANS; QUERCETIN;

EID: 84902279101     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.22     Document Type: Article

References (24)

1. Rousseau A, Mokhtari K, Duyckaerts C. The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol 2008; 21: 720-7.
2. Qi Q, Liu X, Li S, Joshi HC, Ye K. Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth. Acta Pharmacol Sin 2013; 34: 930-8.
3. Liu SS, Wang YF, Ma LS, Zheng BB, Li L, Xie WD, et al. 1-Oxoeudesm-11(13)-eno-12,8a-lactone induces G2/M arrest and apoptosis of human glioblastoma cells in vitro. Acta Pharmacol Sin 2013; 34: 271-81.
4. Stu pp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-96.
5. Py ko IV, Nakada M, Sabit H, Teng L, Furuyama N, Hayashi Y, et al. Glycogen synthase kinase 3beta inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methyla tion via c-Myc signaling. Carcinogenesis 2013; 34: 2206-17.
6. Riccitelli E, Giussani P, Di Vito C, Condomitti G, Tringali C, Caroli M, et al. Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. PLoS One 2013; 8: e68229.
7. Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, Sarkisian MR, et al. The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med 2013; 5: 1196-212.
8. Gielen PR,Aftab Q,Ma N,Chen VC,Hong X,Lozinsky S,et al. Connexin43 confers temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway, Ne uropharmacology,2013,75, 539-48.
9. Beier D, Schulz JB, Beier CP. Chemoresistance of glioblastoma cancer stem cells - much more complex than expected. Mol Cancer 2011; 10: 128.
10. Acunzo J, Katsogiannou M, Rocchi P. Small heat shock proteins HSP27 (HspB1), alphaB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. Int J Biochem Cell Biol 2012; 44: 1622-31.
11. Wei L, Liu TT, Wang HH, Hong HM, Yu AL, Feng HP, et al. Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factorkappaB. Breast Cancer Res 2011;13 : R101.
12. Garrido C, Fromentin A, Bonnotte B, Favre N, Moutet M, Arrigo AP, et al. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res 1998; 58: 5495-9.
13. Hsu HS, Lin JH, Huang WC, Hsu TW, Su K, Chiou SH, et al. Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27. Cancer 2011; 117: 1516-28.
14. Chen SF, Nieh S, Jao SW, Liu CL, Wu CH, Chang YC, et al. Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells. PLoS One 2012; 7: e49275.
15. Schultz CR, Golembieski WA, King DA, Brown SL, Brodie C, Rempel SA. Inhibition of HSP27 alone or in combination with pAKT inhibition as th erapeutic approaches to target SPARC-induced glioma cell survival. Mol Cancer 2012; 11: 20.
16. Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, et al. Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPBALL cell line. FEBS Lett 1999; 462: 322-8.
17. Min K, Ebeler SE. Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. Food Chem Toxicol 2008; 46: 96-104.
18. Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352: 997-1003.
19. Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene co rrelates with MGMT expression in human glioma cells. J Biol Chem 1994; 269: 17228-37.
20. Zhang D, Wong LL, Koay ES. Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer. Mol Cancer 2007; 6: 52.
21. Kostenko S, Moens U. Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology. Cell Mol Life Sci 2009; 66: 3289-307.
22. Shin KD, Lee MY, Shin DS, Lee S, Son KH, Koh S, et al. Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. J Biol Chem 2005; 280: 41439-48.
23. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 1994; 54: 4952-7.
24. Jakub owicz-Gil J, Langner E, Wer tel I, Piersiak T, Rzeski W. Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line. Chem Biol Interact 2010; 188: 190-203.