Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress

Cancer Research

Volumn 61, Issue 5, 2001, Pages 1791-1795

  Shukla, Arti ^a   Timblin, Cynthia R ^a   Hubbard, Andrea K ^b   Bravman, Jonathan ^a   Mossman, Brooke T ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CROCIDOLITE; SILICON DIOXIDE; STRESS ACTIVATED PROTEIN KINASE; TETRAMETHYLUREA; THIOUREA DERIVATIVE; TRANSCRIPTION FACTOR AP 1; TUMOR PROMOTER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; FRA 1 ONCOGENE; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTO ONCOGENE; STEADY STATE; STEM CELL; TRANSACTIVATION;

ANIMALS; CELL LINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; HYDROXYL RADICAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; PULMONARY ALVEOLI; RNA, MESSENGER; S PHASE; SILICON DIOXIDE; THIOUREA; TRANSCRIPTION FACTOR AP-1;

EID: 0035266157     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

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14. JunB differs from c-Jun in its DNA-binding and dimerization domains and represses c-Jun by formation of inactive heterodimers
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