Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-α converting enzyme and matrix metalloproteinases, in models of airway inflammation

British Journal of Pharmacology

Volumn 135, Issue 7, 2002, Pages 1655-1664

  Trifilieff, Alexandre ^a   Walker, Christoph ^a   Keller, Thomas ^a   Kottirsch, Georg ^b   Neumann, Ulf ^b  

^a Novartis Institutes for Biomedical Research   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

in vivo; Inflammation; Lung; Matrix metalloproteinases; TNF converting enzyme

Indexed keywords

ANTIINFLAMMATORY AGENT; COLLAGENASE; COLLAGENASE 3; ELASTASE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MYELOPEROXIDASE; N4 (2,2 DIMETHYL 1 METHYLCARBAMOYLPROPYL) N1 HYDROXY 2 HYDROXYMETHYL 3 (4 METHOXYPHENYL)SUCCINAMIDE; N4 (2,2 DIMETHYL 1 METHYLCARBAMOYLPROPYL) N1 HYDROXY 2 HYDROXYMETHYL 3 PHENYLSUCCINAMIDE; PKF 241 466; PKF 242 484; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; EOSINOPHIL; FEMALE; HUMAN; IC 50; INFLAMMATION; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MONONUCLEAR CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; RESPIRATORY TRACT DISEASE; T LYMPHOCYTE;

ADAM PROTEINS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYDROXAMIC ACIDS; LIPOPOLYSACCHARIDES; MACROPHAGES; MATRIX METALLOPROTEINASES; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEUTROPHILS; OVALBUMIN; PANCREATIC ELASTASE; PNEUMONIA; PROTEASE INHIBITORS;

EID: 0036971187     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704616     Document Type: Article

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