Exocrine pancreatic insufficiency in diabetes mellitus: A complication of diabetic neuropathy or a different type of diabetes?

Experimental Diabetes Research

Volumn 2011, Issue , 2011, Pages

  Hardt, Philip D ^a   Ewald, Nils ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PANCREAS HORMONE; INSULIN;

AUTOIMMUNITY; CHRONIC PANCREATITIS; DIABETES MELLITUS; DIABETIC NEUROPATHY; DIABETIC PATIENT; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MORPHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS EXOCRINE INSUFFICIENCY; PANCREAS FUNCTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; ANIMAL; METABOLISM; PANCREAS; PATHOLOGY; RISK FACTOR;

ANIMALS; AUTOIMMUNITY; DIABETES MELLITUS; DIABETIC NEUROPATHIES; EXOCRINE PANCREATIC INSUFFICIENCY; HUMANS; INSULIN; PANCREAS, EXOCRINE; PANCREATIC HORMONES; RISK FACTORS;

EID: 80053529657     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2011/761950     Document Type: Review

References (63)

1. Pollard H. M., Miller L., Brewer W. A., External secretion of the pancreas and diabetes (study of secretin test) The American Journal of Digestive Diseases 1943 10 1 20 23
2. Chey W. Y., Shay H., Shuman C. R., External pancreatic secretion in diabetes mellitus Annals of Internal Medicine 1963 59 812 821
3. Vacca J. B., Henke W. J., Knight W. A., The exocrine pancreas in diabetes mellitus Annals of Internal Medicine 1964 61 242 247
4. Frier B. M., Saunders J. H. B., Wormsley K. G., Bouchier I. A. D., Exocrine pancreatic function in juvenile-onset diabetes mellitus Gut 1976 17 9 685 691
5. Lankisch P. G., Manthey G., Otto J., Talaulicar M., Willms B., Creutzfeldt W., Exocrine pancreatic function in insulin-dependent diabetes mellitus Digestion 1982 25 210 216
6. Grger G., Layer P., Exocrine pancreatic function in diabetes mellitus The European Journal of Gastroenterology and Hepatology 1995 7 740 746
7. Gepts W., Pathologic anatomy of the pancreas in juvenile diabetes mellitus Diabetes 1965 14 10 619 633
8. MacLean N., Ogilvie R. F., Observations on the pancreatic islet tissue of young diabetic subjects Diabetes 1959 8 2 83 91
9. Le Compte P. M., Gepts W., Volk B. W., Wellmann K. F., The pathology of juvenile diabetes The Diabetic Pancreas 1977 New York, NY, USA Plenum Press 325 363
10. Scheefers-Borchel U., Scheefers H., Arnold R., Fischer P., Sziegoleit A., Pankreatische Elastase 1: Parameter fr die chronische und akute Pankreatitis Laboratoriumsmedizin 1992 16 12 427 432 (Pubitemid 23020684)
11. Sziegoleit A., Krause E., Klr H. U., Kanacher L., Linder D., Elastase 1 and chymotrypsin B in pancreatic juice and feces Clinical Biochemistry 1989 22 2 85 89 (Pubitemid 19121436)
12. Lser C., Mllgaard A., Flsch U. R., Faecal elastase 1: a novel, highly sensitive and specific tubeless pancreatic function test Gut 1996 39 4 580 586
13. Stein J., Spirchez Z., Lembcke B., Caspary W. F., Investigations to the diagnostic value of elastase 1 test Zeitschrift fur Gastroenterologie 1997 supplement 1 122 129
14. Dominguez-Munoz J. E., Hieronymus C., Sauerbruch T., Malfertheiner P., Fecal elastase test: evaluation of a new noninvasive pancreatic function test The American Journal of Gastroenterology 1995 90 10 1834 1837
15. Hardt P. D., Krauss A., Bretz L., Porsch-Oezcueruemez M., Schnell-Kretschmer H., Mser E., Bretzel R. G., Zekorn T., Klr H. U., Pancreatic exocrine function in patients with type-1 and type-2 diabetes mellitus Acta Diabetologica 2000 37 3 105 110 (Pubitemid 32157309)
16. Hardt P. D., Hauenschild A., Nalop J., Marzeion A. M., Jaeger C., Teichmann J., Bretzel R. G., Hollenhorst M., Kloer H. U., High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients Pancreatology 2003 3 5 395 402 (Pubitemid 37409868)
17. Rathmann W., Haastert B., Icks A., Low fecal elastase 1 concentrations in type 2 diabetes Scandinavian Journal of Gastroenterology 2001 36 1056 1061 (Pubitemid 32801690)
18. Icks A., Haastert B., Giani G., Rathmann W., Low fecal elastase-1 in type I diabetes mellitus Zeitschrift fur Gastroenterologie 2001 39 10 823 830 (Pubitemid 33020961)
19. Cavalot F., Bonomo K., Perna P., Bacillo E., Salacone P., Gallo M., Mattiello L., Trovati M., Gaia E., Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual -cell secretion and metabolic control in type 1 diabetic subjects Diabetes Care 2004 27 8 2052 2054 (Pubitemid 38989255)
20. Harano Y., Kim C. I., Kang M., External pancreatic dysfunction associated with diabetes mellitus Journal of Laboratory and Clinical Medicine 1978 91 780 790 (Pubitemid 8332284)
21. Bretzke G., Diabetes mellitus und exokrine Pankreas funktion Zeitschrift fur die Gesamte Innere Medizin und Ihre Grenzgebiete 1984 39 16 388 390 (Pubitemid 14046630)
22. El Newihi H., Dooley C. P., Saad C., Staples J., Zeidler A., Valenzuela J. E., Impaired exocrine pancreatic function in diabetics with diarrhea and peripheral neuropathy Digestive Diseases and Sciences 1988 33 6 705 710
23. Hardt P. D., Kloer H. U., Johnson C. D., Imrie C. W., Diabetes mellitus and exocrine pancreatic disease Pancreatic Disease 1998 2nd London, UK Springer 235 241
24. Nunes A. C., Pontes J. M., Rosa A., Gomes L., Carvalheiro M., Freitas D., Screening for pancreatic exocrine insufficiency in patients with diabetes mellitus The American Journal of Gastroenterology 2003 98 12 2672 2675 (Pubitemid 38028556)
25. Yilmaztepe A., Ulukaya E., Ersoy C., Yilmaz M., Tokullugil H. A., Investigation of fecal pancreatic elastase-1 levels in type 2 diabetic patients The Turkish Journal of Gastroenterology 2005 16 2 75 80 (Pubitemid 41020237)
26. Hardt P. D., Hauenschild A., Jaeger C., Teichmann J., Bretzel R. G., Kloer H. U., High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations a prospective multicenter study Digestive Diseases and Sciences 2003 48 9 1688 1692 (Pubitemid 37174716)
27. Cavalot F., Bonomo K., Fiora E., Bacillo E., Salacone P., Chirio M., Gaia E., Trovati M., Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes? Diabetes Care 2006 29 3 719 721 (Pubitemid 44115385)
28. Creutzfeldt W., Gleichmann D., Otto J., Stckmann F., Maisonneuve P., Lankisch P. G., Follow-up of exocrine pancreatic function in type-1 diabetes mellitus Digestion 2005 72 2-3 71 75 (Pubitemid 41507265)
29. Ebert R., Creutzfeldt W., Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution Diabetologia 1980 19 3 198 204 (Pubitemid 10003179)
30. Herrmann C., Gke R., Fehmann H. C., Richter G., Arnold R., Gke B., Glucagon-like peptide 1 and glucose-dependent insulin-releasing polypeptide secretion in response to nutrients Digestion 1995 56 2 117 126
31. Blumenthal H. T., Probstein J. G., Berns A. W., Interrelationship of diabetes mellitus and pancreatitis Archives of Surgery 1963 87 844 850
32. Olsen R. S., The incidence and clinical relevance of chronic inflammation in the pancreas in autopsy material Acta Pathologica et Microbiologica ScandinavicaSection A 1978 86 5 361 364
33. Foulis A. K., Stewart J. A., The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue Diabetologia 1984 26 6 456 461 (Pubitemid 14080823)
34. Rahier J., Goebbels R. M., Henquin J. C., Cellular composition of the human diabetic pancreas Diabetologia 1983 24 5 366 371 (Pubitemid 13092224)
35. Nakanishi K., Kobayashi T., Miyashita H., Okubo M., Sugimoto T., Murase T., Hashimoto M., Fukuchi S., Kosaka K., Exocrine pancreatic ductograms in insulin-dependent diabetes mellitus The American Journal of Gastroenterology 1994 89 5 762 766 (Pubitemid 24132062)
36. Hardt P. D., Killinger A., Nalop J., Schnell-Kretschmer H., Zekorn T., Klr H. U., Chronic pancreatitis and diabetes mellitus. A retrospective analysis of 156 ERCP investigations in patients with insulin-dependent and non-insulin-dependent diabetes mellitus Pancreatology 2002 2 1 30 32
37. Chiarelli F., Verrotti A., Altobelli E., Blasetti A., Morgese G., Size of the pancreas in type I diabetic children and adolescents Diabetes Care 1995 18 11 1505 1506
38. Fonseca V., Berger L. A., Beckett A. G., Dandona P., Size of pancreas in diabetes mellitus: a study based on ultrasound The British Medical JournalClinical Research 1985 291 6504 1240 1241 (Pubitemid 16216812)
39. Gilbeau J. P., Poncelet V., Libon E., Derue G., Heller F. R., The density, contour and thickness of the pancreas in diabetics The American Journal of Roentgenology 1992 159 3 527 531
40. Bilgin M., Balci N. C., Momtahen A. J., Bilgin Y., Klr H. U., Rau W. S., MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1 Journal of Clinical Gastroenterology 2009 43 2 165 170
41. Williams J. A., Goldfine I. D., The insulin-pancreatic acinar axis Diabetes 1985 34 10 980 986 (Pubitemid 16236516)
42. Adler G., Kern H. F., Regulation of exocrine pancreatic secretory process by insulin Hormone and Metabolic Research 1975 7 4 290 296
43. Korc M., Owerbach D., Quinto C., Rutter W. J., Pancreatic islet-acinar cell interaction: amylase messenger RNA levels are determined by insulin Science 1981 213 4505 351 353 (Pubitemid 11012150)
44. Lhr M., Klppel G., Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type i (insulin dependent) diabetes mellitus and microangiopathy Diabetologia 1987 30 10 757 762
45. Henderson J. R., Why are the islets of Langerhans? The Lancet 1969 2 7618 469 470
46. Unger R. H., Aguilar-Parada E., Mller W. A., Eisentraut A. M., Studies of pancreatic alpha cell function in normal and diabetic subjects The Journal of Clinical Investigation 1970 49 4 837 848
47. Dyck W. P., Rudick J., Hoexter B., Janowitz H. D., Influence of glucagon on pancreatic exocrine secretion Gastroenterology 1969 56 3 531 537
48. Gyr K., Beglinger C., Kohler E., Trautzl U., Keller U., Bloom S. R., Circulating somatostatin. Physiological regulator of pancreatic function? The Journal of Clinical Investigation 1987 79 1595 1600 (Pubitemid 17117261)
49. Patel J. Y., Weir G. C., Increased somatostatin content of islets from streptozotocin-diabetic rats Clinical Endocrinology 1976 5 2 191 194
50. Tanaka S., Kobayashi T., Nakanishi K., Okubo M., Odawara M., Murase T., Hashimoto M., Watanabe G., Matsushita H., Inoko H., Takeuchi K., Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis: pathological examinations of the endocrine and exocrine pancreas Annals of the New York Academy of Sciences 2002 958 152 159 (Pubitemid 34592217)
51. Klppel G., Lttges J., Lhr M., Zamboni G., Longnecker D., Autoimmune pancreatitis: pathological, clinical and immunological features Pancreas 2003 27 1 14 19 (Pubitemid 36775973)
52. Kobayashi T., Nakanishi K., Kajio H., Morinaga S., Sugimoto T., Murase T., Kosaka K., Pancreatic cytokeratin: an antigen of pancreatic exocrine cell autoantibodies in type 1 (insulin-dependent) diabetes mellitus Diabetologia 1990 33 6 363 370 (Pubitemid 20189295)
53. Panicot L., Mas E., Thivolet C., Lombardo D., Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetes Diabetes 1999 48 12 2316 2323 (Pubitemid 30395422)
54. Imagawa A., Hanafusa T., Miyagawa J. I., Matsuzawa Y., A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies The New England Journal of Medicine 2000 342 5 301 307 (Pubitemid 30075242)
55. Taniguchi T., Okazaki K., Okamoto M., Seko S., Tanaka J., Uchida K., Nagashima K., Kurose T., Yamada Y., Chiba T., Seino Y., High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: concept of autoimmune exocrinopathy and endocrinopathy of the pancreas Pancreas 2003 27 1 26 30 (Pubitemid 36775975)
56. Gnther O., Zur tiologie des Diabetes Mellitus 1961 Berlin, Germany Akademie-Verlag
57. Alberti K. G. M. M., Tiengo A., Alberti K. G. M. M., DelPrato S., Vranic M., Diabetes secondary to pancreatopathy: an example of brittle diabetes Diabetes Secondary to Pancreatopathy. International Congress Series 762 1988 Amsterdam, The Netherlands Excerpta Medica 7 20
58. Hardt P. D., Brendel M. D., Kloer H. U., Bretzel R. G., Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed? Diabetes Care 2008 31 S165 S169
59. Pirart J., Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 Diabetes Care 1978 1 4 252 263 (Pubitemid 9210135)
60. Strian F., Halsbeck M., Mehnert H., Standl E., Usadel K. H., Hring H. U., Neurologische Erkrankungen Diabetologie in Klinik und Praxis 2003 Stuttgart, Germany Thieme 802 805
61. Ewald N., Raspe A., Kaufmann C., Bretzel R. G., Kloer H. U., Hardt P. D., Determinants of exocrine pancreatic function as measured by fecal elastase-1 concentrations (FEC) in patients with diabetes mellitus The European Journal of Medical Research 2009 14 3 118 122
62. Vesterhus M., Rder H., Aurlien H., Gjesdal C. G., Bredrup C., Holm P. I., Molven A., Bindoff L., Berstad A., Njlstad P. R., Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations Diabetes Care 2008 31 9 1738 1740
63. Davidai G., Zakaria T., Goldstein R., Gilai A., Freier S., Hypovitaminosis E induced neuropathy in exocrine pancreatic failure Archives of Disease in Childhood 1986 61 901 903 (Pubitemid 16013863)