Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: A candidate for enzyme replacement therapy

Biophysical Chemistry

Volumn 172, Issue , 2013, Pages 43-52

  Wang, H ^a   Hagedorn, J ^b   Svendsen, A ^c   Borch, K ^c   Otzen, D E ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b ABBOTT GMBH AND CO KG   (Germany)

^c NOVOZYMES A S   (Denmark)

Author keywords

Acid condition; Chemical denaturation; Gastric simulation; Refolding; SDS; Taurocholate

Indexed keywords

BILE SALT; ENZYME VARIANT; GUANIDINE; THERMOMYCES LANUGINOSUS LIPASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CALORIMETRY; DRUG STABILITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REPLACEMENT; ENZYME STABILITY; GEL ELECTROPHORESIS; PH; PRIORITY JOURNAL; SPECTROSCOPY;

ASCOMYCOTA; BILE ACIDS AND SALTS; CALORIMETRY, DIFFERENTIAL SCANNING; ENZYME REPLACEMENT THERAPY; EXOCRINE PANCREATIC INSUFFICIENCY; GASTROINTESTINAL AGENTS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LIPASE; MUTANT PROTEINS; MUTATION; PROTEIN FOLDING;

THERMOMYCES LANUGINOSUS;

EID: 84873445883     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2012.12.003     Document Type: Article

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