Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Chen, Peng ^a,b   Wang, Haibin ^a   Duan, Zhijian ^b   Zou, June X ^b   Chen, Hongwu ^b   He, Wei ^a   Wang, Junjian ^b  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RELATED RECEPTOR ALPHA; METHOTREXATE; PROTEIN; PROTEIN NOXA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XAF1 PROTEIN; ANTINEOPLASTIC ANTIMETABOLITE; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; PMAIP1 PROTEIN, HUMAN; PROTEIN BCL 2; SIGNAL PEPTIDE; TP53 PROTEIN, HUMAN; TUMOR PROTEIN; XAF1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; SIGNAL TRANSDUCTION; U2OS CELL LINE; ADOLESCENT; BONE NEOPLASMS; CHILD; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; OSTEOSARCOMA; PRESCHOOL CHILD; TUMOR CELL LINE;

ADOLESCENT; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, NEOPLASM; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METHOTREXATE; NEOPLASM PROTEINS; OSTEOSARCOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84902208618     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/616025     Document Type: Article

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