IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells

Journal of Immunology

Volumn 192, Issue 12, 2014, Pages 5687-5694

  Huber, Jonathan P ^a,c   Gonzales Van Horn, Sarah R ^a   Roybal, Kole T ^a   Gill, Michelle A ^b   Farrar, J David ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DEOXYRIBONUCLEASE I; HISTONE H3; INTERLEUKIN 4; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 3;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DNA BINDING; DNA METHYLATION; ENHANCER REGION; EPIGENETICS; EXON; GATA3 GENE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; NUCLEOSOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH2 CELL;

ADULT; DNA METHYLATION; ENHANCER ELEMENTS, GENETIC; EXONS; FEMALE; GATA3 TRANSCRIPTION FACTOR; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-4; MALE; SIGNAL TRANSDUCTION; TH2 CELLS; TRANSCRIPTION, GENETIC;

EID: 84902198586     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301908     Document Type: Article

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