Reciprocal responsiveness to interleukin-12 and interferon-α specifies human CD8+ effector versus central memory T-cell fates

Blood

Volumn 113, Issue 22, 2009, Pages 5516-5525

  Ramos, Hilario J ^a   Davis, Ann M ^a   Cole, Alexander G ^a   Schatzle, John D ^a,b   Forman, James ^a   Farrar, J David ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; T LYMPHOCYTE RECEPTOR; ALPHA BETA INTERFERON RECEPTOR; IFNAR1 PROTEIN, HUMAN;

ARTICLE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL FATE; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECT; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-ALPHA; INTERLEUKIN-12; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERLEUKIN-12;

EID: 67049145844     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-11-188458     Document Type: Article

References (45)

1. + T cells. Immunol Rev. 2006;211:81-92.
2. Valenzuela J, Schmidt C, Mescher M. The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells. J Immunol. 2002; 169:6842-6849. (Pubitemid 36899269)
3. Curtsinger JM, Valenzuela JO, Agarwal P, Lins D, Mescher MF. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol. 2005;174:4465-4469. (Pubitemid 40504523)
4. Casey KA, Mescher MF. IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype. J Immunol. 2007;178:7640-7648.
5. Cousens LP, Peterson R, Hsu S, et al. Two roads diverged: interferon α/β- and interleukin 12-mediated pathways in promoting T cell interferon γ responses during viral infection. J Exp Med. 1999;189:1315-1328. (Pubitemid 29198269)
6. Theofilopoulos AN, Baccala R, Beutler B, Kono DH. Type I interferons (α/β) in immunity and autoimmunity. Annu Rev Immunol. 2005;23:307-335.
7. + T cells. J Exp Med. 1999; 189:1355-1360.
8. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science. 2002;295:338-342.
9. Sullivan BM, Juedes A, Szabo SJ, von Herrath M, Glimcher LH. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A. 2003;100:15818-15823. (Pubitemid 38021073)
10. + T cells in vivo. J Immunol. 1999;163:2561-2567.
11. Chang J, Cho JH, Lee SW, Choi SY, Ha SJ, Sung YC. IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells. J Immunol. 2004;172:2818-2826. (Pubitemid 38263666)
12. Way SS, Havenar-Daughton C, Kolumam GA, Orgun NN, Murali-Krishna K. IL-12 and type-I IFN synergize for IFN-γ production by CD4 T cells, whereas neither are required for IFN-γ production by CD8 T cells after Listeria monocytogenes infection. J Immunol. 2007;178:4498-4505. (Pubitemid 46492402)
13. Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med. 2005;202:637-650. (Pubitemid 41248415)
14. + T cell differentiation. J Immunol. 2006;177:7515-7519.
15. + T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007;27:281-295.
16. + T cells. J Exp Med. 2007;204:2015-2021.
17. Ramos HJ, Davis AM, George TC, Farrar JD. IFN-α is not sufficient to drive Th1 development due to lack of stable T-bet expression. J Immunol. 2007;179:3792-3803.
18. Kataoka T, Shinohara N, Takayama H, et al. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol. 1996;156:3678-3686. (Pubitemid 26139940)
19. +- ATPase, on CTL-mediated cytotoxicity. J Immunol. 1994;153:3938-3947.
20. Shaulov A, Murali-Krishna K. CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu. J Immunol. 2008; 180:1131-1138.
21. Sallusto F, Langenkamp A, Geginat J, Lanzavecchia A. Functional subsets of memory T cells identified by CCR7 expression. Curr Top Microbiol Immunol. 2000;251:167-171. (Pubitemid 30691267)
22. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712. (Pubitemid 129515761)
23. Taqueti VR, Grabie N, Colvin R, et al. T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol. 2006;177:5890-5901. (Pubitemid 44628802)
24. + T cells expressing CXCR3. J Leukocyte Biol. 2006;80:320-329.
25. + T-cell trafficking. Blood. 2005;106:3432-3439.
26. + T lymphocytes. J Immunol. 2007; 178:4112-4119.
27. Debes GF, Arnold CN, Young AJ, et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol. 2005; 6:889-894.
28. + T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005;6: 1236-1244.
29. Wherry EJ, Teichgraber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003; 4:225-234. (Pubitemid 36322131)
30. + memory T-cell subsets in response to antigen or homeostatic cytokines. Blood. 2003;101:4260-4266.
31. Gett AV, Sallusto F, Lanzavecchia A, Geginat J. T cell fitness determined by signal strength. Nat Immunol. 2003;4:355-360. (Pubitemid 36432318)
32. Sarkar S, Teichgraber V, Kalia V, et al. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol. 2007;179:6704-6714.
33. + T cell differentiation during viral infection. Immunity. 2007;27:393-405.
34. + T cell subsets requires cell cycle progression. J Immunol. 2006;177:1981-1987.
35. + T cells. J Immunol. 1999;162:3256-3262.
36. Havenar-Daughton C, Kolumam GA, Murali- Krishna K. Cutting edge: the direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol. 2006;176:3315-3319. (Pubitemid 43363977)
37. McKinstry KK, Golech S, Lee WH, Huston G, Weng NP, Swain SL. Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med. 2007;204:2199-2211. (Pubitemid 47360879)
38. Chang JT, Palanivel VR, Kinjyo I, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007;315:1687-1691. (Pubitemid 46515618)
39. Usharauli D, Kamala T. Brief antigenic stimulation generates effector CD8 T cells with low cytotoxic activity and high IL-2 production. J Immunol. 2008;180:4507-4513.
40. + T cell responses from primary to persistent phases of Epstein-Barr virus infection. J Exp Med. 2002;195:893-905.
41. Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A. 2004;101:16004-16009. (Pubitemid 39507917)
42. Veiga-Fernandes H, Rocha B. High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division. Nat Immunol. 2004;5: 31-37. (Pubitemid 38081466)
43. Koyanagi M, Fukada K, Uchiyama T, Yagi J, Arimura Y. Long-term exposure to superantigen induces p27Kip1 and Bcl-2 expression in effector memory CD4+ T cells. Cell Immunol. 2007;248:77-85. (Pubitemid 350299021)
44. Lohning M, Hegazy AN, Pinschewer DD, et al. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med. 2008;205: 53-61. (Pubitemid 351185715)
45. Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT. Memory CD4 T cells emerge from effector T-cell progenitors. Nature. 2008;452:356-360.