c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

Blood

Volumn 116, Issue 8, 2010, Pages 1280-1290

  Nakata, Yuji ^a   Brignier, Anne C ^a   Jin, Shenghao ^a   Shen, Yuan ^a   Rudnick, Stephen I ^a,b   Sugita, Mayumi ^a   Gewirtz, Alan M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HISTONE H3; INTERLEUKIN 4; METHIONINE; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN C MYB; TRANSCRIPTION FACTOR GATA 3;

ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA METHYLATION; EFFECTOR CELL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; TH2 CELL;

EID: 77956526237     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-05-223255     Document Type: Article

References (45)

1. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol. 2006;6(4):329-333.
2. Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature. 2008;453(7198):1051-1057. (Pubitemid 351871737)
3. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997;89(4):587-596. (Pubitemid 27511769)
4. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295(5553):338-342.
5. Zhou M, Ouyang W. The function role of GATA-3 in Th1 and Th2 differentiation. Immunol Res. 2003;28(1):25-37. (Pubitemid 37088540)
6. Ho IC, Pai SY. GATA-3: not just for Th2 cells anymore. Cell Mol Immunol. 2007;4(1):15-29.
7. Rothenberg EV, Moore JE, Yui MA. Launching the T-cell-lineage developmental programme. Nat Rev Immunol. 2008;8(1):9-21.
8. Ouyang W, Lohning M, Gao Z, et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity. 2000;12(1):27-37. (Pubitemid 30069212)
9. Lee HJ, Takemoto N, Kurata H, et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med. 2000;192(1):105-115. (Pubitemid 30470811)
10. Zhou M, Ouyang W, Gong Q, et al. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp Med. 2001;194(10):1461-1471. (Pubitemid 33081521)
11. Ranganath S, Murphy KM. Structure and specificity of GATA proteins in Th2 development. Mol Cell Biol. 2001;21(8):2716-2725. (Pubitemid 32244916)
12. Maurice D, Hooper J, Lang G, Weston K. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J. 2007;26(15):3629-3640. (Pubitemid 47236884)
13. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science. 2002;295(5556):868-872. (Pubitemid 34118370)
14. Nakata Y, Shetzline S, Sakashita C, et al. c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol. 2007;27(6):2048-2058. (Pubitemid 46418463)
15. Westin EH, Gallo RC, Arya SK, et al. Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A. 1982;79(7):2194-2198. (Pubitemid 12093236)
16. Oh IH, Reddy EP. The myb gene family in cell growth, differentiation and apoptosis. Oncogene. 1999;18(19):3017-3033.
17. Asnagli H, Afkarian M, Murphy KM. Cutting edge: identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol. 2002;168(9):4268-4271. (Pubitemid 34441323)
18. Amsen D, Antov A, Jankovic D, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 2007;27(1):89-99. (Pubitemid 47096801)
19. Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007;27(1):100-110. (Pubitemid 47096803)
20. George KM, Leonard MW, Roth ME, et al. Embryonic expression and cloning of the murine GATA-3 gene. Development. 1994;120(9):2673-2686. (Pubitemid 24268840)
21. Gregoire JM, Romeo PH. T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer. J Biol Chem. 1999;274(10):6567- 6578. (Pubitemid 29111074)
22. Grogan JL, Locksley RM. T helper cell differentiation: on again, off again. Curr Opin Immunol. 2002;14(3):366-372.
23. Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 1993;13(7):3999-4010. (Pubitemid 23187628)
24. Jin S, Zhao H, Yi Y, Nakata Y, Kalota A, Gewirtz AM. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J Clin Invest. 2010;120(2):593-606.
25. Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004;18(7):816-829. (Pubitemid 38480893)
26. Yamashita M, Hirahara K, Shinnakasu R, et al. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity. 2006;24(5):611-622. (Pubitemid 43728153)
27. Nakayama T, Yamashita M. Initiation and maintenance of Th2 cell identity. Curr Opin Immunol. 2008;20(3):265-271.
28. Dai P, Akimaru H, Tanaka Y, et al. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 1996;10(5):528-540.
29. Oelgeschlager M, Janknecht R, Krieg J, Schreek S, Luscher B. Interaction of the coactivator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 1996;15(11):2771- 2780. (Pubitemid 26176254)
30. Gewirtz AM, Anfossi G, Venturelli D, Valpreda S, Sims R, Calabretta B. G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science. 1989;245(4914):180-183. (Pubitemid 19193934)
31. Allen RD 3rd, Bender TP, Siu G. c-Myb is essential for early T cell development. Genes Dev. 1999;13(9):1073-1078. (Pubitemid 29233139)
32. Pearson R, Weston K. c-Myb regulates the proliferation of immature thymocytes following betaselection. EMBO J. 2000;19(22):6112-6120.
33. Emambokus N, Vegiopoulos A, Harman B, Jenkinson E, Anderson G, Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003;22(17):4478-4488. (Pubitemid 37087201)
34. Bender TP, Kremer CS, Kraus M, Buch T, Rajewsky K. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004;5(7):721-729. (Pubitemid 39023304)
35. Lieu YK, Kumar A, Pajerowski AG, Rogers TJ, Reddy EP. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A. 2004;101(41):14853-14858. (Pubitemid 39410764)
36. Hooper J, Maurice D, Argent-Katwala MJ, Weston K. Myb proteins regulate expression of histone variant H2A.Z during thymocyte development. Immunology. 2008;123(2):282-289.
37. Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol. 2006;24:607-656.
38. Blokzijl A, ten Dijke P, Ibanez CF. Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr Biol. 2002;12(1):35-45. (Pubitemid 34063351)
39. Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev. 2000;14(6):627-644.
40. Chen GY, Sakuma K, Kannagi R. Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes. J Biol Chem. 2008;283(50):34563-34570.
41. Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol. 2001;2(1):45-50. (Pubitemid 33704952)
42. Yokoyama A, Wang Z, Wysocka J, et al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol. 2004;24(13):5639-5649. (Pubitemid 38787950)
43. Yokoyama A, Cleary ML. Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell. 2008;14(1):36-46. (Pubitemid 351885493)
44. Agarwal SK, Kennedy PA, Scacheri PC, et al. Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res. 2005;37(6):369-374.
45. Balogh K, Racz K, Patocs A, Hunyady L. Menin and its interacting proteins: elucidation of menin function. Trends Endocrinol Metab. 2006;17(9):357-364. (Pubitemid 44584731)