Synchronous colorectal cancer: Clinical, pathological and molecular implications

World Journal of Gastroenterology

Volumn 20, Issue 22, 2014, Pages 6815-6820

  Lam, Alfred King Yin ^a   Chan, Sally Sze Yan ^a   Leung, Melissa ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Colorectal carcinoma; Microsatellite instability; Prevalence; Review; Synchronous carcinoma

Indexed keywords

B RAF KINASE; GLUTATHIONE TRANSFERASE; K RAS PROTEIN; PROTEIN P53; TUMOR MARKER;

AGE; ARTICLE; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER RISK; CANCER SURGERY; COLLOID CARCINOMA; COLONOSCOPY; COLORECTAL CANCER; COMPUTED TOMOGRAPHIC COLONOGRAPHY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA METHYLATION; ENDOSCOPIC SUBMUCOSAL DISSECTION; FAMILIAL COLON POLYPOSIS; FEMALE; FOLLOW UP; GENDER; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; INFLAMMATORY BOWEL DISEASE; MALE; MICROSATELLITE INSTABILITY; MOLECULAR BIOLOGY; PATHOLOGY; PREVALENCE; ADENOMA; CARCINOMA; COLORECTAL NEOPLASMS; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; MULTIPLE CANCER; MUTATION; PERSONALIZED MEDICINE; PHENOTYPE; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS; RISK FACTOR;

ADENOMA; CARCINOMA; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; INDIVIDUALIZED MEDICINE; MALE; MICROSATELLITE INSTABILITY; MUTATION; NEOPLASMS, MULTIPLE PRIMARY; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84902169315     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i22.6815     Document Type: Article

References (63)

1. Welch JP. Multiple colorectal tumors. An appraisal of natural history and therapeutic options. Am J Surg 1981; 142: 274-280 [PMID: 7258541 DOI: 10.1016/0002-9610(81)90292-0]
2. Kaibara N, Koga S, Jinnai D. Synchronous and metachronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer 1984; 54: 1870-1874 [PMID: 6478423 DOI: 10.1002/1097-0142(1984 1101)54:9<1870::AID-CNCR2820540917>3.0.CO;2-5]
3. Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg 1984; 71: 941-943 [PMID: 6498470 DOI: 10.1002/bjs.1800711210]
4. Langevin JM, Nivatvongs S. The true incidence of synchronous cancer of the large bowel. A prospective study. Am J Surg 1984; 147: 330-333 [PMID: 6703204 DOI: 10.1016/0002-9610(84)90161-2]
5. Greenstein AJ, Slater G, Heimann TM, Sachar DB, Aufses AH. A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer. Ann Surg 1986; 203: 123-128 [PMID: 3947149 DOI: 10.1097/00000658-198602000-00002]
6. Finan PJ, Ritchie JK, Hawley PR. Synchronous and 'early' metachronous carcinomas of the colon and rectum. Br J Surg 1987; 74: 945-947 [PMID: 3664228 DOI: 10.1002/ bjs.1800741021]
7. Wagner HE, Barbier PA, Luder PJ, Niederhäuser U. Prognosis in synchronous colorectal carcinomas. Z Gastroenterol 1988; 26: 117-120 [PMID: 2577928]
8. Evers BM, Mullins RJ, Matthews TH, Broghamer WL, Polk HC. Multiple adenocarcinomas of the colon and rectum. An analysis of incidences and current trends. Dis Colon Rectum 1988; 31: 518-522 [PMID: 3391060 DOI: 10.1007/BF02553724]
9. Adloff M, Arnaud JP, Bergamaschi R, Schloegel M. Synchronous carcinoma of the colon and rectum: prognostic and therapeutic implications. Am J Surg 1989; 157: 299-302 [PMID: 2537586 DOI: 10.1016/0002-9610(89)90555-2]
10. Fegiz G, Ramacciato G, Indinnimeo M, Gozzo P, Valabrega S, De Angelis R, Barillari P. Synchronous large bowel cancer: a series of 47 cases. Ital J Surg Sci 1989; 19: 23-28 [PMID: 2787303]
11. Greig JD, Miller DF. Synchronous and early metachronous carcinomas of the colon and rectum. Acta Chir Scand 1989; 155: 287-289 [PMID: 2800878]
12. Eu KW, Seow-Choen F, Goh HS. Synchronous colorectal cancer in an Oriental population. Int J Colorectal Dis 1993; 8: 193-196 [PMID: 8163891 DOI: 10.1007/BF00290304]
13. Kimura T, Iwagaki H, Fuchimoto S, Hizuta A, Orita K. Synchronous colorectal carcinomas. Hepatogastroenterology 1994; 41: 409-412 [PMID: 7851846]
14. Hayakumo T, Cho E, Nakajima M, Kato G, Kawai K, Azuma T. Point mutations in the c-K-ras 2 gene in multiple colorectal carcinomas. J Gastroenterol Hepatol 1995; 10: 70-75 [PMID: 7620111 DOI: 10.1111/j.1440-1746.1995.tb01051.x]
15. Fante R, Roncucci L, Di Gregorioc MG, Losi L, Benatti P, Pedroni M, Percesepe A, De Pietri S, Ponz de Leon M. Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma. Cancer 1996; 77: 2013-2021 [PMID: 8640664]
16. Passman MA, Pommier RF, Vetto JT. Synchronous colon primaries have the same prognosis as solitary colon cancers. Dis Colon Rectum 1996; 39: 329-334 [PMID: 8603557 DOI: 10.1007/BF02049477]
17. Koness RJ, King TC, Schechter S, McLean SF, Lodowsky C, Wanebo HJ. Synchronous colon carcinomas: moleculargenetic evidence for multicentricity. Ann Surg Oncol 1996; 3: 136-143 [PMID: 8646513 DOI: 10.1007/BF02305792]
18. Takeuchi H, Toda T, Nagasaki S, Kawano T, Minamisono Y, Maehara Y, Sugimachi K. Synchronous multiple colorectal adenocarcinomas. J Surg Oncol 1997; 64: 304-307 [PMID: 9142187 DOI: 10.1002/(SICI)1096-9098(199704)64:4<304:: AID-JSO10>3.0.CO;2-2]
19. Bekdash B, Harris S, Broughton CI, Caffarey SM, Marks CG. Outcome after multiple colorectal tumours. Br J Surg 1997; 84: 1442-1444 [PMID: 9361609 DOI: 10.1002/bjs.1800841028]
20. Pedroni M, Tamassia MG, Percesepe A, Roncucci L, Benatti P, Lanza G, Gafà R, Di Gregorio C, Fante R, Losi L, Gallinari L, Scorcioni F, Vaccina F, Rossi G, Cesinaro AM, Ponz de Leon M. Microsatellite instability in multiple colorectal tumors. Int J Cancer 1999; 81: 1-5 [PMID: 10077143 DOI: 10.100 2/(SICI)1097-0215(19990331)81:1<1::AID-IJC1>3.0.CO;2-K]
21. Box JC, Rodriguez-Bigas MA, Weber TK, Petrelli NJ. Clinical implications of multiple colorectal carcinomas in hereditary nonpolyposis colorectal carcinoma. Dis Colon Rectum 1999; 42: 717-721 [PMID: 10378594 DOI: 10.1007/BF02236924]
22. Brueckl WM, Limmert T, Brabletz T, Guenther K, Jung A, Hermann K, Wiest GH, Kirchner T, Hohenberger W, Hahn EG, Wein A. Mismatch repair deficiency in sporadic synchronous colorectal cancer. Anticancer Res 2000; 20: 4727-4732 [PMID: 11205208]
23. Eguchi K, Yao T, Konomoto T, Hayashi K, Fujishima M, Tsuneyoshi M. Discordance of p53 mutations of synchronous colorectal carcinomas. Mod Pathol 2000; 13: 131-139 [PMID: 10697269 DOI: 10.1038/modpathol.3880024]
24. Chen HS, Sheen-Chen SM. Synchronous and "early" metachronous colorectal adenocarcinoma: analysis of prognosis and current trends. Dis Colon Rectum 2000; 43: 1093-1099 [PMID: 10950007 DOI: 10.1007/BF02236556]
25. Abe Y, Masuda H, Okubo R. Microsatellite instability of each tumor in sporadic synchronous multiple colorectal cancers. Oncol Rep 2001; 8: 299-304 [PMID: 11182044]
26. Chirila DN, Popp RA, Balacescu O, Turdeanu NA, Constantea NA, Pop TR, Vesa SC, Ciuce C. GST gene variants in synchronous colorectal cancers and synchronous association of colorectal cancers with other cancers. Chirurgia (Bucur) 2013; 108: 365-371 [PMID: 23790786]
27. Norrie MW, Hawkins NJ, Todd AV, Meagher AP, O'Connor TW, Ward RL. The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas. Dis Colon Rectum 2002; 45: 674-680 [PMID: 12004219 DOI: 10.1007/s10350-004-6266-1]
28. Oya M, Takahashi S, Okuyama T, Yamaguchi M, Ueda Y. Synchronous colorectal carcinoma: clinico-pathological features and prognosis. Jpn J Clin Oncol 2003; 33: 38-43 [PMID: 12604723 DOI: 10.1093/jjco/hyg010]
29. Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T. Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol 2003; 8: 162-167 [PMID: 12851840 DOI: 10.1007/ s10147-003-0322-z]
30. Dykes SL, Qui H, Rothenberger DA, García-Aguilar J. Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer. Cancer 2003; 98: 48-54 [PMID: 12833454 DOI: 10.1002/cncr.11445]
31. Wang HZ, Huang XF, Wang Y, Ji JF, Gu J. Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma. World J Gastroenterol 2004; 10: 2136-2139 [PMID: 15237453]
32. Nikoloudis N, Saliangas K, Economou A, Andreadis E, Siminou S, Manna I, Georgakis K, Chrissidis T. Synchronous colorectal cancer. Tech Coloproctol 2004; 8 Suppl 1: s177-s179 [PMID: 15655614 DOI: 10.1007/s10151-004-0149-2]
33. Papadopoulos V, Michalopoulos A, Basdanis G, Papapolychroniadis K, Paramythiotis D, Fotiadis P, Berovalis P, Harlaftis N. Synchronous and metachronous colorectal carcinoma. Tech Coloproctol 2004; 8 Suppl 1: s97-s100 [PMID: 15655657 DOI: 10.1007/s10151-004-0124-y]
34. Ikeda Y, Saku M, Kawanaka H, Muranaka T, Takeshita M, Watanabe J, Yoshida K, Sugimachi K. Distribution of synchronous and metachronous multiple colorectal cancers. Hepatogastroenterology 2004; 51: 443-446 [PMID: 15086178]
35. Piñol V, Andreu M, Castells A, Payá A, Bessa X, Jover R. Synchronous colorectal neoplasms in patients with colorectal cancer: predisposing individual and familial factors. Dis Colon Rectum 2004; 47: 1192-1200 [PMID: 15164252 DOI: 10.1007/s10350-004-0562-7]
36. Velayos FS, Lee SH, Qiu H, Dykes S, Yiu R, Terdiman JP, Garcia-Aguilar J. The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer. J Gastrointest Surg 2005; 9: 329-335 [PMID: 15749592 DOI: 10.1016/j.gassur.2004.05.007]
37. Fukatsu H, Kato J, Nasu JI, Kawamoto H, Okada H, Yamamoto H, Sakaguchi K, Shiratori Y. Clinical characteristics of synchronous colorectal cancer are different according to tumour location. Dig Liver Dis 2007; 39: 40-46 [PMID: 16996329 DOI: 10.1016/j.dld.2006.07.015]
38. Latournerie M, Jooste V, Cottet V, Lepage C, Faivre J, Bouvier AM. Epidemiology and prognosis of synchronous colorectal cancers. Br J Surg 2008; 95: 1528-1533 [PMID: 18991301 DOI: 10.1002/bjs.6382]
39. Tziris N, Dokmetzioglou J, Giannoulis K, Kesisoglou I, Sapalidis K, Kotidis E, Gambros O. Synchronous and metachronous adenocarcinomas of the large intestine. Hippokratia 2008; 12: 150-152 [PMID: 18923668]
40. Yalcinkaya U, Ozturk E, Ozgur T, Yerci O, Yilmazlar T. P53 expression in synchronous colorectal cancer. Saudi Med J 2008; 29: 826-831 [PMID: 18521459]
41. Aslanian HR, Burgart LJ, Harrington JJ, Mahoney DW, Zinsmeister AR, Thibodeau SN, Ahlquist DA. Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers. Clin Gastroenterol Hepatol 2008; 6: 1385-1388 [PMID: 18639494 DOI: 10.1016/j.cgh.2008.04.027]
42. Konishi K, Shen L, Jelinek J, Watanabe Y, Ahmed S, Kaneko K, Kogo M, Takano T, Imawari M, Hamilton SR, Issa JP. Concordant DNA methylation in synchronous colorectal carcinomas. Cancer Prev Res (Phila) 2009; 2: 814-822 [PMID: 19737982 DOI: 10.1158/1940-6207.CAPR-09-0054]
43. Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology 2009; 137: 1609-20. e1-3 [PMID: 19686742]
44. Gonzalo V, Lozano JJ, Muñoz J, Balaguer F, Pellisé M, Rodríguez de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A. Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PLoS One 2010; 5: e8777 [PMID: 20098741 DOI: 10.1371/journal.pone.0008777]
45. Kiran RP, Khoury W, Church JM, Lavery IC, Fazio VW, Remzi FH. Colorectal cancer complicating inflammatory bowel disease: similarities and differences between Crohn's and ulcerative colitis based on three decades of experience. Ann Surg 2010; 252: 330-335 [PMID: 20622662 DOI: 10.1097/ SLA.0b013e3181e61e69]
46. Lam AK, Carmichael R, Gertraud Buettner P, Gopalan V, Ho YH, Siu S. Clinicopathological significance of synchronous carcinoma in colorectal cancer. Am J Surg 2011; 202: 39-44 [PMID: 21600553 DOI: 10.1016/j.amjsurg.2010.05.012]
47. Mulder SA, Kranse R, Damhuis RA, de Wilt JH, Ouwendijk RJ, Kuipers EJ, van Leerdam ME. Prevalence and prognosis of synchronous colorectal cancer: a Dutch population-based study. Cancer Epidemiol 2011; 35: 442-447 [PMID: 21470938 DOI: 10.1016/j.canep.2010.12.007]
48. Derwinger K, Gustavsson B. A study of aspects on gender and prognosis in synchronous colorectal cancer. Clin Med Insights Oncol 2011; 5: 259-264 [PMID: 21912492 DOI: 10.4137/ CMO.S7871]
49. Mohammadi M, Kristensen MH, Nielsen HJ, Bonde JH, Holck S. Qualities of sessile serrated adenoma/polyp/lesion and its borderline variant in the context of synchronous colorectal carcinoma. J Clin Pathol 2012; 65: 924-927 [PMID: 22782936 DOI: 10.1136/jclinpath-2012-200803]
50. Bae JM, Cho NY, Kim TY, Kang GH. Clinicopathologic and molecular characteristics of synchronous colorectal cancers: heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors. Dis Colon Rectum 2012; 55: 181-190 [PMID: 22228162 DOI: 10.1097/ DCR.0b013e31823c46ce]
51. Liu X, Goldblum JR, Zhao Z, Landau M, Heald B, Pai R, Lin J. Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: in comparison with sporadic microsatellite-stable and Lynch syndrome-related colorectal adenocarcinoma. Am J Surg Pathol 2012; 36: 1228-1233 [PMID: 22790862 DOI: 10.1097/ PAS.0b013e318253645a]
52. Hu H, Chang DT, Nikiforova MN, Kuan SF, Pai RK. Clinicopathologic features of synchronous colorectal carcinoma: A distinct subset arising from multiple sessile serrated adenomas and associated with high levels of microsatellite instability and favorable prognosis. Am J Surg Pathol 2013; 37: 1660-1670 [PMID: 23887157 DOI: 10.1097/PAS.0b013e31829623b8]
53. Şavlovschi C, Comandaşu M, Şerban D. Specifics of diagnosis and treatment in synchronous colorectal cancers (SCC). Chirurgia (Bucur) 2013; 108: 43-45 [PMID: 23464768]
54. Ueda E, Watanabe T, Umetani N, Ishigami H, Sasaki S, Nagawa H. Microsatellite instability of cancers and concomitant adenomas in synchronous multiple colorectal cancer patients. J Exp Clin Cancer Res 2002; 21: 149-154 [PMID: 12148569]
55. Lam AK, Gopalan V, Carmichael R, Buettner PG, Leung M, Smith R, Lu CT, Ho YH, Siu S. Metachronous carcinomas in colorectum and its clinicopathological significance. Int J Colorectal Dis 2012; 27: 1303-1310 [PMID: 22828957 DOI: 10.1007/s00384-012-1474-y]
56. King-Yin Lam A, Ong K, Ho YH. Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression. Dis Colon Rectum 2006; 49: 1275-1283 [PMID: 16912910]
57. Pakneshan S, Salajegheh A, Smith RA, Lam AK. Clinicopathological relevance of BRAF mutations in human cancer. Pathology 2013; 45: 346-356 [PMID: 23594689 DOI: 10.1097/ PAT.0b013e328360b61d]
58. Pritchard CC, Grady WM. Colorectal cancer molecular biology moves into clinical practice. Gut 2011; 60: 116-129 [PMID: 20921207 DOI: 10.1136/gut.2009.206250]
59. Ogino S, Goel A. Molecular classification and correlates in colorectal cancer. J Mol Diagn 2008; 10: 13-27 [PMID: 18165277 DOI: 10.2353/jmoldx.2008.070082]
60. Weekes J, Lam AK, Sebesan S, Ho YH. Irinotecan therapy and molecular targets in colorectal cancer: a systemic review. World J Gastroenterol 2009; 15: 3597-3602 [PMID: 19653336 DOI: 10.3748/wjg.15.3597]
61. Lam AK, Ong K, Ho YH. hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features. Int J Colorectal Dis 2008; 23: 587-594 [PMID: 18322660 DOI: 10.1007/s00384-008-0455-7]
62. Di Pietro G, Magno LA, Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol 2010; 6: 153-170 [PMID: 20078251 DOI: 10.1517 /17425250903427980]
63. Park SH, Lee JH, Lee SS, Kim JC, Yu CS, Kim HC, Ye BD, Kim MJ, Kim AY, Ha HK. CT colonography for detection and characterisation of synchronous proximal colonic lesions in patients with stenosing colorectal cancer. Gut 2012; 61: 1716-1722 [PMID: 22115824 DOI: 10.1136/gutjnl-2011-301135]