The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas

Diseases of the Colon and Rectum

Volumn 45, Issue 5, 2002, Pages 674-680

  Norrie, Mark W A ^a,b   Hawkins, Nicholas J ^b   Todd, Alison V ^c   Meagher, Alan P ^a   O'Connor, Terence W ^a   Ward,, Robyn L ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

Colorectal carcinoma; hMLH1 hypermethylation; Methylation specific polymerase chain reaction; Microsatellite instability; Synchronous tumors

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CANCER SUSCEPTIBILITY; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; GENE FUNCTION; HUMAN; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PROMOTER REGION;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BASE PAIR MISMATCH; CARRIER PROTEINS; CHI-SQUARE DISTRIBUTION; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; FEMALE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES;

EID: 0036246807     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10350-004-6266-1     Document Type: Article

References (25)

1. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
2. Prognosis of colorectal cancer varies in different high-risk conditions
3. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
4. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
5. Synchronous colorectal carcinomas
6. Synchronous carcinoma of the colon and rectum
7. Synchronous carcinoma of the colon and rectum: Prognostic and therapeutic implications
8. Multiple synchronous colorectal carcinomas: A ploidy study by image analysis
9. A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer
10. Recognition and treatment of patients with hereditary nonpolyposis colon cancer (Lynch syndromes I and II)
11. Mismatch repair deficiency in sporadic synchronous colorectal cancer
12. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC
13. Multiple primary malignant tumors. A survey of the literature and statistical study
14. Multiple carcinomas of the large intestine. A review of the literature and a study of 261 cases
15. Microsatellite instability and the pathological features of sporadic colorectal cancer
16. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
17. Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands
18. Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
19. CpG island methylator phenotype in colorectal cancer
20. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
21. Microsatellite instability in multiple colorectal tumors
22. Synchronous colon carcinomas: Molecular-genetic evidence for multicentricity
23. Discordance of p53 mutations of synchronous colorectal carcinomas
24. Carcinogenesis and natural selection: A new perspective to the genetics and epigenetics of colorectal cancer