Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: In comparison with sporadic microsatellite-stable and lynch syndrome-related colorectal adenocarcinoma

American Journal of Surgical Pathology

Volumn 36, Issue 8, 2012, Pages 1228-1233

  Liu, Xiuli ^a   Goldblum, John R ^a   Zhao, Zijin ^b   Landau, Michael ^a   Heald, Brandie ^a   Pai, Rish ^a   Lin, Jingmei ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

colorectal adenocarcinoma; Crohn disease; genetic instability; inflammatory bowel disease; Lynch syndrome; microsatellite instability; ulcerative colitis

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; COLORECTAL TUMOR; COMPARATIVE STUDY; ENTERITIS; FEMALE; GENETICS; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; PATHOLOGY; TISSUE MICROARRAY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; TISSUE ARRAY ANALYSIS; YOUNG ADULT;

EID: 84863833884     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318253645a     Document Type: Article

References (25)

1. Bernstein CN, Blanchard JF, Kliewer E, et al. Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer. 2001;91:854-862. (Pubitemid 32173312)
2. Brentnall TA, Rubin CE, Crispin DA, et al. A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis. Gastroenterology. 1995;109:151-155.
3. Bronner MP, Skacel M, Crispin DA, et al. Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single nondysplastic biopsies distinguish progressors from non-progressors. Mod Pathol. 2010;23:1624-1633.
4. Choi PM, Zelig MP. Similarity of colorectal cancer in Crohn's disease and ulcerative colitis: implications for carcinogenesis and prevention. Gut. 1994;35:950-954.
5. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526-535. (Pubitemid 32234798)
6. Ekbom A, Helmick C, Zack M, et al. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323:1228-1233. (Pubitemid 20366527)
7. Fleisher AS, Esteller M, Harpaz N, et al. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res. 2000;60:4864-4868.
8. Greenson JK, Hunag SC, Herron C, et al. Pathologic predictors of microsatellite instability in colorectal cancer. Am J Surg Pathol. 2009;33:126-133.
9. Gupta RB, Harpaz N, Itzkowitz S, et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007;133:1099-1105. (Pubitemid 47494461)
10. Gyde S, Prior P, Dew MJ, et al. Mortality in ulcerative colitis. Gastroenterology. 1982;83:36-43. (Pubitemid 12123685)
11. Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851-1860.
12. Jass JR, Atkin WS, Cuzick J, et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology. 1986;10:437-459. (Pubitemid 16039125)
13. Kornfeld D, Ekbom A, Ihre T. Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study. Gut. 1997;41:522-525.
14. Loftus E. Epidemiology and risk factors for colorectal dysplasia and cancer in ulcerative colitis. Gastroenterol Clin North Am. 2006; 35:517-531.
15. Lyda MH, Noffsinger A, Belli J, et al. Microsatellite instability and K-ras mutations in patients with ulcerative colitis. Hum Pathol. 2000;31:665-671. (Pubitemid 30445468)
16. Noffsinger A, Kretschmer S, Belli J, et al. Microsatellite instability is uncommon in intestinal mucosa of patients with Crohn's disease. Dig Dis Sci. 2000;45:378-384. (Pubitemid 30133902)
17. Noffsinger AE, Belli JM, Fogt F, et al. Germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis. Hum Pathol. 1999;30:8-12. (Pubitemid 29037387)
18. Potack J, Itzkowitz SH. Colorectal cancer in inflammatory bowel disease. Gut Liver. 2008;2:61-73.
19. Rutter M, Saunders B, Wilkinson K, et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology. 2004;126:451-459. (Pubitemid 38182302)
20. Sanchez JA, Dejulius KL, Bronner M, et al. Relative role of methylator and tumor suppressor pathways in ulcerative colitisassociated colon cancer. Inflamm Bowel Dis. 2011;17:1966-1970.
21. Suraweera N, Duval A, Reperant M, et al. Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology. 2002;123: 1804-1811. (Pubitemid 35408304)
22. Terzić J, Grivennikov S, Karin E, et al. Inflammation and colon cancer. Gastroenterology. 2010;138:2101-2114.
23. van Dieren JM, Wink JC, Vissers KJ, et al. Chromosomal and microsatellite instability of adenocarcinomas and dysplastic lesions (DALM) in ulcerative colitis. Diagn Mol Pathol. 2006;15:216-222. (Pubitemid 44813660)
24. Xie J, Itzkowitz SH. Cancer in inflammatory bowel disease. World J Gastroenterol. 2008;14:378-389. (Pubitemid 351320846)
25. Yagishita H, Yoshida T, Ishiguro K, et al. Epithelial and stromal genetic instability linked to tumor suppressor genes in ulcerative colitis-associated tumorigenesis. Scand J Gastroenterol. 2008;43: 559-566. (Pubitemid 351536049)