Mismatch repair deficiency in sporadic synchronous colorectal cancer

Anticancer Research

Volumn 20, Issue 6 C, 2000, Pages 4727-4732

  Brueckl, W M ^a   Limmert, T ^a   Brabletz, T ^a   Guenther, K ^a   Jung, A ^a   Hermann, K ^a   Wiest, G H ^a   Kirchner, T ^a   Hohenberger, W ^a   Hahn, E G ^a   Wein, A ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

DNA mismatch repair (MMR); HNPCC; Microsatellite instability (MSI); Synchronous colorectal cancer (SCRC)

Indexed keywords

GENE PRODUCT; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BASE MISPAIRING; CLINICAL ARTICLE; COLORECTAL CANCER; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; BASE PAIR MISMATCH; CARRIER PROTEINS; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS;

EID: 0034494085     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Multiple primary malignant tumors. A survey of the literature and a statistical study
2. Multiple carcinomas of the large intestine. A review of literature and a study of 261 cases
3. Multiple colorectal tumors: An appraisal of natural history and therapeutic options
4. Incidence of synchronous and metachronous colorectal carcinoma
5. Lessons from heereditary colorectal cancer
6. Analysis of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients
7. Mediating mismatch repair
8. Clues to the pathogenesis of familial colorectal cancer
9. Microsatellite instability and the role of hMSH in sporadic colorectal cancer
10. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
11. Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair
12. Validation and simplification of Bethesda Guidelines for identifying apparently sporadic forms of colorectal carcinoma with microsatellite instability
13. Two types of sporadic multiple colorectal cancers with and without HNPCC-like genetic instability
14. Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection
15. Microsatellite instability in multiple colorectal tumors
16. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
17. Towards a molecular classification of colorectal cancer
18. Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers
19. Characterisation of a subtype of colorectal cancer combing features of the suppressor and mild mutator pathways
20. DNA mismatch binding defects, DNA damage tolerance and mutator phenotypes in human colorectal carcinoma cell lines
21. Roles of the DNA mismatch repair genes in colorectal tumorigenesis
22. Microsatellite instability in human cancer: A prognostic marker for chemotherapy
23. p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon cancer