메뉴 건너뛰기




Volumn 32, Issue 7, 2014, Pages 1774-1788

Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the signaling pathway

Author keywords

Atrial cardiomyocytes; BMP Signaling; Cardiac differentiation; Embryoid bodies; Embryonic stem cells; Pluripotent stem cells

Indexed keywords

ALPHA FETOPROTEIN; BETA TUBULIN; BONE MORPHOGENETIC PROTEIN 2; CD31 ANTIGEN; CHORDIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GREMLIN 2; HEMOGLOBIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; MYOCARDIN; MYOSIN HEAVY CHAIN; PROTEIN INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR COUPTFII; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HEY1; TRANSCRIPTION FACTOR NKX2.5; TROPONIN T; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; GREM2 PROTEIN, MOUSE; PROTEIN;

EID: 84902099178     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1703     Document Type: Article
Times cited : (45)

References (82)
  • 1
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
    • Doetschman TC, Eistetter H, Katz M, et al. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 1985; 87: 27-45.
    • (1985) J Embryol Exp Morphol , vol.87 , pp. 27-45
    • Doetschman, T.C.1    Eistetter, H.2    Katz, M.3
  • 2
    • 18844396119 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation: Emergence of a new era in biology and medicine
    • Keller G,. Embryonic stem cell differentiation: Emergence of a new era in biology and medicine. Genes Dev 2005; 19: 1129-1155.
    • (2005) Genes Dev , vol.19 , pp. 1129-1155
    • Keller, G.1
  • 3
    • 33750456216 scopus 로고    scopus 로고
    • Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages
    • Kattman SJ, Huber TL, Keller GM,. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 2006; 11: 723-732.
    • (2006) Dev Cell , vol.11 , pp. 723-732
    • Kattman, S.J.1    Huber, T.L.2    Keller, G.M.3
  • 4
    • 33845457194 scopus 로고    scopus 로고
    • Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    • Moretti A, Caron L, Nakano A, et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 2006; 127: 1151-1165.
    • (2006) Cell , vol.127 , pp. 1151-1165
    • Moretti, A.1    Caron, L.2    Nakano, A.3
  • 5
    • 33845442108 scopus 로고    scopus 로고
    • Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
    • Wu SM, Fujiwara Y, Cibulsky SM, et al. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 2006; 127: 1137-1150.
    • (2006) Cell , vol.127 , pp. 1137-1150
    • Wu, S.M.1    Fujiwara, Y.2    Cibulsky, S.M.3
  • 6
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    • Yang L, Soonpaa MH, Adler ED, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 2008; 453: 524-528.
    • (2008) Nature , vol.453 , pp. 524-528
    • Yang, L.1    Soonpaa, M.H.2    Adler, E.D.3
  • 7
    • 70249116787 scopus 로고    scopus 로고
    • The FunGenES database: A genomics resource for mouse embryonic stem cell differentiation
    • Schulz H, Kolde R, Adler P, et al. The FunGenES database: A genomics resource for mouse embryonic stem cell differentiation. PLoS ONE 2009; 4: e6804.
    • (2009) PLoS ONE , vol.4
    • Schulz, H.1    Kolde, R.2    Adler, P.3
  • 8
    • 22844439586 scopus 로고    scopus 로고
    • Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells
    • Yuasa S, Itabashi Y, Koshimizu U, et al. Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotechnol 2005; 23: 607-611.
    • (2005) Nat Biotechnol , vol.23 , pp. 607-611
    • Yuasa, S.1    Itabashi, Y.2    Koshimizu, U.3
  • 9
    • 84864380948 scopus 로고    scopus 로고
    • Cardiac differentiation of human pluripotent stem cells
    • Jiang J, Han P, Zhang Q, et al. Cardiac differentiation of human pluripotent stem cells. J Cell Mol Med 2012; 16: 1663-1668.
    • (2012) J Cell Mol Med , vol.16 , pp. 1663-1668
    • Jiang, J.1    Han, P.2    Zhang, Q.3
  • 10
    • 84864243791 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview
    • Mummery CL, Zhang J, Ng ES, et al. Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview. Circ Res 2012; 111: 344-358.
    • (2012) Circ Res , vol.111 , pp. 344-358
    • Mummery, C.L.1    Zhang, J.2    Ng, E.S.3
  • 11
    • 84857639549 scopus 로고    scopus 로고
    • Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway
    • Onizuka T, Yuasa S, Kusumoto D, et al. Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway. Mol Cell Cardiol 2012; 52: 650-659.
    • (2012) Mol Cell Cardiol , vol.52 , pp. 650-659
    • Onizuka, T.1    Yuasa, S.2    Kusumoto, D.3
  • 12
    • 51449091152 scopus 로고    scopus 로고
    • Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells
    • Hao J, Daleo MA, Murphy CK, et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008; 3: e2904.
    • (2008) PLoS ONE , vol.3
    • Hao, J.1    Daleo, M.A.2    Murphy, C.K.3
  • 13
    • 84555218139 scopus 로고    scopus 로고
    • Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling
    • Ni TT, Rellinger EJ, Mukherjee A, et al. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol 2011; 18: 1658-1668.
    • (2011) Chem Biol , vol.18 , pp. 1658-1668
    • Ni, T.T.1    Rellinger, E.J.2    Mukherjee, A.3
  • 14
    • 84855433908 scopus 로고    scopus 로고
    • Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells
    • Rai M, Walthall JM, Hu J, et al,. Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells. Stem Cells Dev 2012; 21: 54-66.
    • (2012) Stem Cells Dev , vol.21 , pp. 54-66
    • Rai, M.1    Walthall, J.M.2    Hu, J.3
  • 15
    • 84875443414 scopus 로고    scopus 로고
    • GATA factors efficiently direct cardiac fate from embryonic stem cells
    • Turbendian HK, Gordillo M, Tsai SY, et al. GATA factors efficiently direct cardiac fate from embryonic stem cells. Development 2013; 140: 1639-1644.
    • (2013) Development , vol.140 , pp. 1639-1644
    • Turbendian, H.K.1    Gordillo, M.2    Tsai, S.Y.3
  • 16
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • Zhang J, Wilson GF, Soerens AG, et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 2009; 104: e30-41.
    • (2009) Circ Res , vol.104
    • Zhang, J.1    Wilson, G.F.2    Soerens, A.G.3
  • 17
    • 84863393681 scopus 로고    scopus 로고
    • Bmp signaling exerts opposite effects on cardiac differentiation
    • de Pater E, Ciampricotti M, Priller F, et al. Bmp signaling exerts opposite effects on cardiac differentiation. Circ Res 2012; 110: 578-587.
    • (2012) Circ Res , vol.110 , pp. 578-587
    • De Pater, E.1    Ciampricotti, M.2    Priller, F.3
  • 18
    • 0035313303 scopus 로고    scopus 로고
    • A role for BMP signalling in heart looping morphogenesis in Xenopus
    • Breckenridge RA, Mohun TJ, Amaya E,. A role for BMP signalling in heart looping morphogenesis in Xenopus. Dev Biol 2001; 232: 191-203.
    • (2001) Dev Biol , vol.232 , pp. 191-203
    • Breckenridge, R.A.1    Mohun, T.J.2    Amaya, E.3
  • 19
    • 34247560264 scopus 로고    scopus 로고
    • Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    • Chocron S, Verhoeven MC, Rentzsch F, et al. Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev Biol 2007; 305: 577-588.
    • (2007) Dev Biol , vol.305 , pp. 577-588
    • Chocron, S.1    Verhoeven, M.C.2    Rentzsch, F.3
  • 20
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • Zhang H, Bradley A,. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 1996; 122: 2977-2986.
    • (1996) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 21
    • 31144440253 scopus 로고    scopus 로고
    • Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    • Ma L, Lu MF, Schwartz RJ, et al. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 2005; 132: 5601-5611.
    • (2005) Development , vol.132 , pp. 5601-5611
    • Ma, L.1    Lu, M.F.2    Schwartz, R.J.3
  • 22
    • 1842481058 scopus 로고    scopus 로고
    • Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling
    • Liu W, Selever J, Wang D, et al. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci USA 2004; 101: 4489-4494.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4489-4494
    • Liu, W.1    Selever, J.2    Wang, D.3
  • 23
    • 55549092471 scopus 로고    scopus 로고
    • BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development
    • McCulley DJ, Kang JO, Martin JF, et al. BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn 2008; 237: 3200-3209.
    • (2008) Dev Dyn , vol.237 , pp. 3200-3209
    • McCulley, D.J.1    Kang, J.O.2    Martin, J.F.3
  • 24
    • 0032915460 scopus 로고    scopus 로고
    • Early embryonic lethality in Bmp5:Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
    • Solloway MJ, Robertson EJ,. Early embryonic lethality in Bmp5:Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 1999; 126: 1753-1768.
    • (1999) Development , vol.126 , pp. 1753-1768
    • Solloway, M.J.1    Robertson, E.J.2
  • 25
    • 0035879140 scopus 로고    scopus 로고
    • Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart
    • Kim RY, Robertson EJ, Solloway MJ,. Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. Dev Biol 2001; 235: 449-466.
    • (2001) Dev Biol , vol.235 , pp. 449-466
    • Kim, R.Y.1    Robertson, E.J.2    Solloway, M.J.3
  • 26
    • 2042462926 scopus 로고    scopus 로고
    • BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    • Chen H, Shi S, Acosta L, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development 2004; 131: 2219-2231.
    • (2004) Development , vol.131 , pp. 2219-2231
    • Chen, H.1    Shi, S.2    Acosta, L.3
  • 27
    • 33846796028 scopus 로고    scopus 로고
    • The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis
    • Choi M, Stottmann RW, Yang YP, et al. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 2007; 100: 220-228.
    • (2007) Circ Res , vol.100 , pp. 220-228
    • Choi, M.1    Stottmann, R.W.2    Yang, Y.P.3
  • 28
    • 0035858884 scopus 로고    scopus 로고
    • Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation
    • Monzen K, Hiroi Y, Kudoh S, et al. Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J Cell Biol 2001; 153: 687-698.
    • (2001) J Cell Biol , vol.153 , pp. 687-698
    • Monzen, K.1    Hiroi, Y.2    Kudoh, S.3
  • 29
    • 79551597211 scopus 로고    scopus 로고
    • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • Kattman SJ, Witty AD, Gagliardi M, et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 2011; 8: 228-240.
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1    Witty, A.D.2    Gagliardi, M.3
  • 30
    • 0033135571 scopus 로고    scopus 로고
    • A mouse cerberus/Dan-related gene family
    • Pearce JJ, Penny G, Rossant J,. A mouse cerberus/Dan-related gene family. Dev Biol 1999; 209: 98-110.
    • (1999) Dev Biol , vol.209 , pp. 98-110
    • Pearce, J.J.1    Penny, G.2    Rossant, J.3
  • 31
    • 0347916881 scopus 로고    scopus 로고
    • Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists
    • Avsian-Kretchmer O, Hsueh AJ,. Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol Endocrinol 2004; 18: 1-12.
    • (2004) Mol Endocrinol , vol.18 , pp. 1-12
    • Avsian-Kretchmer, O.1    Hsueh, A.J.2
  • 32
    • 2542430192 scopus 로고    scopus 로고
    • Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation
    • Sudo S, Avsian-Kretchmer O, Wang LS, et al. Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem 2004; 279: 23134-23141.
    • (2004) J Biol Chem , vol.279 , pp. 23134-23141
    • Sudo, S.1    Avsian-Kretchmer, O.2    Wang, L.S.3
  • 33
    • 0031835609 scopus 로고    scopus 로고
    • Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach
    • Minabe-Saegusa C, Saegusa H, Tsukahara M, et al. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ 1998; 40: 343-353.
    • (1998) Dev Growth Differ , vol.40 , pp. 343-353
    • Minabe-Saegusa, C.1    Saegusa, H.2    Tsukahara, M.3
  • 34
    • 0035213812 scopus 로고    scopus 로고
    • The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung
    • Lu MM, Yang H, Zhang L, et al. The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung. Dev Dyn 2001; 222: 667-680.
    • (2001) Dev Dyn , vol.222 , pp. 667-680
    • Lu, M.M.1    Yang, H.2    Zhang, L.3
  • 35
    • 70449521191 scopus 로고    scopus 로고
    • PRDC regulates placode neurogenesis in chick by modulating BMP signalling
    • Kriebitz NN, Kiecker C, McCormick L, et al. PRDC regulates placode neurogenesis in chick by modulating BMP signalling. Dev Biol 2009; 336: 280-292.
    • (2009) Dev Biol , vol.336 , pp. 280-292
    • Kriebitz, N.N.1    Kiecker, C.2    McCormick, L.3
  • 36
    • 58149503642 scopus 로고    scopus 로고
    • Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro
    • Ideno H, Takanabe R, Shimada A, et al. Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro. Exp Cell Res 2009; 315: 474-484.
    • (2009) Exp Cell Res , vol.315 , pp. 474-484
    • Ideno, H.1    Takanabe, R.2    Shimada, A.3
  • 37
    • 80755152973 scopus 로고    scopus 로고
    • Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    • Zuniga E, Rippen M, Alexander C, et al. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development 2011; 138: 5147-5156.
    • (2011) Development , vol.138 , pp. 5147-5156
    • Zuniga, E.1    Rippen, M.2    Alexander, C.3
  • 38
    • 33749259834 scopus 로고    scopus 로고
    • Expression of the protein related to Dan and Cerberus gene - Prdc - during eye, pharyngeal arch, somite, and swim bladder development in zebrafish
    • Müller II, Knapik EW, Hatzopoulos AK,. Expression of the protein related to Dan and Cerberus gene-prdc-during eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Dev Dyn 2006; 235: 2881-2888.
    • (2006) Dev Dyn , vol.235 , pp. 2881-2888
    • Müller, I.I.1    Knapik, E.W.2    Hatzopoulos, A.K.3
  • 39
    • 84875156629 scopus 로고    scopus 로고
    • Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm
    • Müller II, Melville DB, Tanwar V, et al. Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm. Dis Model Mech 2013; 6: 332-341.
    • (2013) Dis Model Mech , vol.6 , pp. 332-341
    • Müller, I.I.1    Melville, D.B.2    Tanwar, V.3
  • 40
    • 0028279829 scopus 로고
    • Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
    • Mountford P, Zevnik B, Duwel A, et al. Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci USA 1994; 91: 4303-4307.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4303-4307
    • Mountford, P.1    Zevnik, B.2    Duwel, A.3
  • 41
    • 0034726107 scopus 로고    scopus 로고
    • A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells
    • Meyer N, Jaconi M, Landopoulou A, et al. A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. FEBS Lett 2000; 478: 151-158.
    • (2000) FEBS Lett , vol.478 , pp. 151-158
    • Meyer, N.1    Jaconi, M.2    Landopoulou, A.3
  • 42
    • 0038030960 scopus 로고    scopus 로고
    • Cardiac specific differentiation of mouse embryonic stem cells
    • Sachinidis A, Fleischmann BK, Kolossov E, et al. Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res 2003; 58: 278-291.
    • (2003) Cardiovasc Res , vol.58 , pp. 278-291
    • Sachinidis, A.1    Fleischmann, B.K.2    Kolossov, E.3
  • 43
    • 3543053797 scopus 로고    scopus 로고
    • Spatio-temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins
    • Monteiro RM, de Sousa Lope SM, Korchynskyi O, et al. Spatio-temporal activation of Smad1 and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins. J Cell Sci 2004; 117: 4653-4663.
    • (2004) J Cell Sci , vol.117 , pp. 4653-4663
    • Monteiro, R.M.1    De Sousa Lope, S.M.2    Korchynskyi, O.3
  • 44
    • 0026342911 scopus 로고
    • Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice
    • Subramaniam A, Jones WK, Gulick J, et al. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 1991; 266: 24613-24620.
    • (1991) J Biol Chem , vol.266 , pp. 24613-24620
    • Subramaniam, A.1    Jones, W.K.2    Gulick, J.3
  • 45
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 46
    • 46749123531 scopus 로고    scopus 로고
    • Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke
    • Beck H, Semisch M, Culmsee C, et al. Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol 2008; 173: 77-92.
    • (2008) Am J Pathol , vol.173 , pp. 77-92
    • Beck, H.1    Semisch, M.2    Culmsee, C.3
  • 47
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry CE, Keller G,. Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 2008; 132: 661-680.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 48
    • 0025608774 scopus 로고
    • Developmental regulation of myosin gene expression in mouse cardiac muscle
    • Lyons GE, Schiaffino S, Sassoon D, et al. Developmental regulation of myosin gene expression in mouse cardiac muscle. J Cell Biol 1990; 111: 2427-2436.
    • (1990) J Cell Biol , vol.111 , pp. 2427-2436
    • Lyons, G.E.1    Schiaffino, S.2    Sassoon, D.3
  • 49
    • 0029395059 scopus 로고
    • An in vivo analysis of transcriptional elements in the mouse α-myosin heavy chain gene promoter
    • Rindt H, Subramaniam A, Robbins J,. An in vivo analysis of transcriptional elements in the mouse α-myosin heavy chain gene promoter. Trans Res 1995; 4: 397-405.
    • (1995) Trans Res , vol.4 , pp. 397-405
    • Rindt, H.1    Subramaniam, A.2    Robbins, J.3
  • 50
    • 0031281873 scopus 로고    scopus 로고
    • Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis
    • Hescheler J, Fleischmann BK, Lentini S, et al. Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 1997; 36: 149-162.
    • (1997) Cardiovasc Res , vol.36 , pp. 149-162
    • Hescheler, J.1    Fleischmann, B.K.2    Lentini, S.3
  • 51
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization
    • He J, Q Ma, Y Lee, et al. Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization. Circ Res 2003; 93: 32-39.
    • (2003) Circ Res , vol.93 , pp. 32-39
    • He, J.1    Ma, Q.2    Lee, Y.3
  • 52
    • 84867746044 scopus 로고    scopus 로고
    • Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: The matrix sandwich method
    • Zhang J, Klos M, Wilson GF, et al. Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: The matrix sandwich method. Circ Res 2012; 111: 1125-1136.
    • (2012) Circ Res , vol.111 , pp. 1125-1136
    • Zhang, J.1    Klos, M.2    Wilson, G.F.3
  • 53
    • 0028341883 scopus 로고
    • Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
    • Kubalak SW, Miller-Hance WC, O'Brien TX, et al. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem 1994; 269: 16961-16970.
    • (1994) J Biol Chem , vol.269 , pp. 16961-16970
    • Kubalak, S.W.1    Miller-Hance, W.C.2    O'Brien, T.X.3
  • 54
    • 55449124569 scopus 로고    scopus 로고
    • Connexin 40 imparts conduction heterogeneity to atrial tissue
    • Leaf DE, Feig JE, Vasquez C, et al. Connexin 40 imparts conduction heterogeneity to atrial tissue. Circ Res 2008; 103: 1001-1008.
    • (2008) Circ Res , vol.103 , pp. 1001-1008
    • Leaf, D.E.1    Feig, J.E.2    Vasquez, C.3
  • 55
    • 9644259096 scopus 로고    scopus 로고
    • Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development
    • Fleischmann BK, Duan Y, Fan Y, et al. Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development. J Clin Invest 2004; 114: 994-1001.
    • (2004) J Clin Invest , vol.114 , pp. 994-1001
    • Fleischmann, B.K.1    Duan, Y.2    Fan, Y.3
  • 56
    • 25444525786 scopus 로고    scopus 로고
    • Functional roles of Cav1.3(alpha1D) calcium channels in atria: Insights gained from gene-targeted null mutant mice
    • Zhang Z, He Y, Tuteja D, et al. Functional roles of Cav1.3(alpha1D) calcium channels in atria: Insights gained from gene-targeted null mutant mice. Circulation 2005; 112: 1936-1944.
    • (2005) Circulation , vol.112 , pp. 1936-1944
    • Zhang, Z.1    He, Y.2    Tuteja, D.3
  • 57
    • 0036469127 scopus 로고    scopus 로고
    • Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken
    • Houweling AC, Somi S, Van Den Hoff MJ, et al. Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken. Anat Rec 2002; 266: 93-102.
    • (2002) Anat Rec , vol.266 , pp. 93-102
    • Houweling, A.C.1    Somi, S.2    Van Den Hoff, M.J.3
  • 58
    • 0038237303 scopus 로고    scopus 로고
    • Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling
    • Minamisawa S, Wang Y, Chen J, et al. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem 2003; 278: 9570-9575.
    • (2003) J Biol Chem , vol.278 , pp. 9570-9575
    • Minamisawa, S.1    Wang, Y.2    Chen, J.3
  • 59
    • 0027301056 scopus 로고
    • Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube
    • O'Brien TX, Lee KJ, Chien KR,. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci USA 1993; 90: 5157-5161.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5157-5161
    • O'Brien, T.X.1    Lee, K.J.2    Chien, K.R.3
  • 60
    • 80052724445 scopus 로고    scopus 로고
    • Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells
    • Lee MY, Sun B, Schliffke S, et al. Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells. Stem Cell Res 2012; 8: 49-57.
    • (2012) Stem Cell Res , vol.8 , pp. 49-57
    • Lee, M.Y.1    Sun, B.2    Schliffke, S.3
  • 61
    • 0035806899 scopus 로고    scopus 로고
    • Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction
    • Gutstein DE, Morley GE, Vaidya D, et al. Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 2001; 104: 1194-1199.
    • (2001) Circulation , vol.104 , pp. 1194-1199
    • Gutstein, D.E.1    Morley, G.E.2    Vaidya, D.3
  • 62
    • 0033947555 scopus 로고    scopus 로고
    • Differential expression of KvLQT1 isoforms across the human ventricular wall
    • Péréon Y, Demolombe S, Barõ I, et al. Differential expression of KvLQT1 isoforms across the human ventricular wall. Am J Physiol Heart Circ Physiol 2000; 278: H1908-H1915.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Péréon, Y.1    Demolombe, S.2    Barõ, I.3
  • 63
    • 78951477878 scopus 로고    scopus 로고
    • Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels
    • Markandeya YS, Fahey JM, Pluteanu F, et al. Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels. J Biol Chem 2011; 286: 2433-2444.
    • (2011) J Biol Chem , vol.286 , pp. 2433-2444
    • Markandeya, Y.S.1    Fahey, J.M.2    Pluteanu, F.3
  • 64
    • 0345120945 scopus 로고    scopus 로고
    • The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
    • Pereira FA, Qiu Y, Zhou G, et al. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev 1999; 13: 1037-1049.
    • (1999) Genes Dev , vol.13 , pp. 1037-1049
    • Pereira, F.A.1    Qiu, Y.2    Zhou, G.3
  • 65
    • 84878367020 scopus 로고    scopus 로고
    • Atrial identity is determined by a COUP-TFII regulatory network
    • Wu SP, Cheng CM, Lanz RB, et al. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell 2013; 25: 417-426.
    • (2013) Dev Cell , vol.25 , pp. 417-426
    • Wu, S.P.1    Cheng, C.M.2    Lanz, R.B.3
  • 66
    • 0032715827 scopus 로고    scopus 로고
    • HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
    • Nakagawa O, Nakagawa M, Richardson JA, et al. HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol 1999; 216: 72-84.
    • (1999) Dev Biol , vol.216 , pp. 72-84
    • Nakagawa, O.1    Nakagawa, M.2    Richardson, J.A.3
  • 67
    • 33947309902 scopus 로고    scopus 로고
    • Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    • Kokubo H, Tomita-Miyagawa S, Hamada Y, et al. Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development 2007; 134: 747-755.
    • (2007) Development , vol.134 , pp. 747-755
    • Kokubo, H.1    Tomita-Miyagawa, S.2    Hamada, Y.3
  • 68
    • 0033582685 scopus 로고    scopus 로고
    • Regulation of chamber-specific gene expression in the developing heart by Irx4
    • Bao ZZ, Bruneau BG, Seidman JG, et al. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 1999; 283: 1161-1164.
    • (1999) Science , vol.283 , pp. 1161-1164
    • Bao, Z.Z.1    Bruneau, B.G.2    Seidman, J.G.3
  • 69
    • 0035133913 scopus 로고    scopus 로고
    • Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression
    • Bruneau BG, Bao ZZ, Fatkin D, et al. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol 2001; 21: 1730-1736.
    • (2001) Mol Cell Biol , vol.21 , pp. 1730-1736
    • Bruneau, B.G.1    Bao, Z.Z.2    Fatkin, D.3
  • 70
    • 34147188988 scopus 로고    scopus 로고
    • CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression
    • Koibuchi N, Chin MT,. CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression. Circ Res 2007; 100: 850-855.
    • (2007) Circ Res , vol.100 , pp. 850-855
    • Koibuchi, N.1    Chin, M.T.2
  • 71
    • 34249932672 scopus 로고    scopus 로고
    • Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function
    • Xin M, Small EM, van Rooij E, et al. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci USA 2007; 104: 7975-7980.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7975-7980
    • Xin, M.1    Small, E.M.2    Van Rooij, E.3
  • 72
    • 0029831878 scopus 로고    scopus 로고
    • Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps
    • Sasai Y, Lu B, Piccolo S, et al. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J 1996; 15: 4547-4555.
    • (1996) EMBO J , vol.15 , pp. 4547-4555
    • Sasai, Y.1    Lu, B.2    Piccolo, S.3
  • 73
    • 29744437291 scopus 로고    scopus 로고
    • A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors
    • Krizhanovsky V, Ben-Arie N,. A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev 2006; 123: 67-75.
    • (2006) Mech Dev , vol.123 , pp. 67-75
    • Krizhanovsky, V.1    Ben-Arie, N.2
  • 75
    • 22244479745 scopus 로고    scopus 로고
    • Design and synthesis of the first generation of novel potent, selective, and in vivo active (Benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-Terminal Kinase
    • Gaillard P, Jeanclaude-Etter I, Ardisonne V, et al. Design and synthesis of the first generation of novel potent, selective, and in vivo active (Benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-Terminal Kinase. J Med Chem 2005; 48: 4596-4607.
    • (2005) J Med Chem , vol.48 , pp. 4596-4607
    • Gaillard, P.1    Jeanclaude-Etter, I.2    Ardisonne, V.3
  • 76
    • 33845642740 scopus 로고    scopus 로고
    • Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
    • Diez H, Fischer A, Winkler A, et al. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res 2007; 313: 1-9.
    • (2007) Exp Cell Res , vol.313 , pp. 1-9
    • Diez, H.1    Fischer, A.2    Winkler, A.3
  • 77
    • 0037043688 scopus 로고    scopus 로고
    • Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
    • Pandur P, Läsche M, Eisenberg LM, et al. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 2002; 418: 636-641.
    • (2002) Nature , vol.418 , pp. 636-641
    • Pandur, P.1    Läsche, M.2    Eisenberg, L.M.3
  • 78
    • 84881428594 scopus 로고    scopus 로고
    • Structure of protein related to dan and cerberus: Insights into the mechanism of bone morphogenetic protein antagonism
    • Nolan K, Kattamuri C, Luedeke DM, et al. Structure of protein related to dan and cerberus: Insights into the mechanism of bone morphogenetic protein antagonism. Structure 2013; 21: 1417-1429.
    • (2013) Structure , vol.21 , pp. 1417-1429
    • Nolan, K.1    Kattamuri, C.2    Luedeke, D.M.3
  • 79
    • 78649980258 scopus 로고    scopus 로고
    • Myocardial lineage development
    • Evans SM, Yelon D, Conlon FL, et al. Myocardial lineage development. Circ Res 2010; 107: 1428-1444.
    • (2010) Circ Res , vol.107 , pp. 1428-1444
    • Evans, S.M.1    Yelon, D.2    Conlon, F.L.3
  • 80
    • 34447250066 scopus 로고    scopus 로고
    • Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
    • Gaborit N, Le Bouter S, Szuts V, et al. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 2007; 582: 675-693.
    • (2007) J Physiol , vol.582 , pp. 675-693
    • Gaborit, N.1    Le Bouter, S.2    Szuts, V.3
  • 81
    • 20444376531 scopus 로고    scopus 로고
    • Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays
    • Ellinghaus P, Scheubel RJ, Dobrev D, et al. Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays. Thorac Cardiovasc Surg 2005; 129: 1383-1390.
    • (2005) Thorac Cardiovasc Surg , vol.129 , pp. 1383-1390
    • Ellinghaus, P.1    Scheubel, R.J.2    Dobrev, D.3
  • 82
    • 70349759777 scopus 로고    scopus 로고
    • Cardiac repair and regeneration: The Rubik's cube of cell therapy for heart disease
    • Boudoulas KD, Hatzopoulos AK,. Cardiac repair and regeneration: The Rubik's cube of cell therapy for heart disease. Dis Model Mech 2009; 2: 344-358.
    • (2009) Dis Model Mech , vol.2 , pp. 344-358
    • Boudoulas, K.D.1    Hatzopoulos, A.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.