Specification of Macroglia by Transcription Factors: Schwann Cells

Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS

Volumn , Issue , 2013, Pages 759-769

  Meijer, D ^a   Svaren, J ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84902023181     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-397265-1.00082-4     Document Type: Chapter

References (117)

1. Antonellis A., Bennett W.R., Menheniott T.R., et al. Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome. Human Molecular Genetics 2006, 15:259-271.
2. Antonellis A., Dennis M.Y., Burzynski G., et al. A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo. PLoS One 2010, 5:e14346.
3. Antonellis A., Huynh J.L., Lee-Lin S.Q., et al. Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genetics 2008, 4:e1000174.
4. Arthur-Farraj P., Wanek K., Hantke J., et al. Mouse Schwann cells need both NRG1 and cyclic AMP to myelinate. Glia 2011, 59:720-733.
5. Bermingham J.R., Scherer S.S., O'Connell S., et al. Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes & Development 1996, 10:1751-1762.
6. Bermingham J.R., Shearin H., Pennington J., et al. The claw paw mutation reveals a role for Lgi4 in peripheral nerve development. Nature Neuroscience 2006, 9:76-84.
7. Betancur P., Bronner-Fraser M., Sauka-Spengler T. Assembling neural crest regulatory circuits into a gene regulatory network. Annual Review of Cell and Developmental Biology 2010, 26:581-603.
8. Blanchard A.D., Sinanan A., Parmantier E., et al. Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: Comparison with Oct-1, Krox-20, and Pax-3. Journal of Neuroscience Research 1996, 46:630-640.
9. Bondurand N., Girard M., Pingault V., Lemort N., Dubourg O., Goossens M. Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10. Human Molecular Genetics 2001, 10:2783-2795.
10. Bosse F., Zoidl G., Wilms S., Gillen C.P., Kuhn H.G., Muller H.W. Differential expression of two mRNA species indicates a dual function of peripheral myelin protein PMP22 in cell growth and myelination. Journal of Neuroscience Research 1994, 37:529-537.
11. Bremer M., Frob F., Kichko T., et al. Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve. Glia 2011, 59:1022-1032.
12. Britsch S., Goerich D.E., Riethmacher D., et al. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes & Development 2001, 15:66-78.
13. Chen Y., Fischer W.H., Gill G.N. Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH. Journal of Biological Chemistry 1997, 272:14110-14114.
14. Chen Y., Wang H., Yoon S.O., et al. HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination. Nature Neuroscience 2011, 14:437-441.
15. Cheung M., Briscoe J. Neural crest development is regulated by the transcription factor Sox9. Development 2003, 130:5681-5693.
16. Darbas A., Jaegle M., Walbeehm E., et al. Cell autonomy of the mouse claw paw mutation. Developmental Biology 2004, 272:470-482.
17. Deal K.K., Cantrell V.A., Chandler R.L., Saunders T.L., Mortlock D.P., Southard-Smith E.M. Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Developmental Dynamics 2006, 235:1413-1432.
18. Decker L., Desmarquet-Trin-Dinh C., Taillebourg E., Ghislain J., Vallat J.M., Charnay P. Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. Journal of Neuroscience 2006, 26:9771-9779.
19. Denarier E., Forghani R., Farhadi H.F., et al. Functional organization of a Schwann cell enhancer. Journal of Neuroscience 2005, 25:11210-11217.
20. Dib S., Denarier E., Dionne N., Beaudoin M., Friedman H.H., Peterson A.C. Regulatory modules function in a non-autonomous manner to control transcription of the mbp gene. Nucleic Acids Research 2011, 39:2548-2558.
21. Dutton J.R., Antonellis A., Carney T.J., et al. An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10. BMC Developmental Biology 2008, 8:105.
22. Farhadi H.F., Lepage P., Forghani R., et al. A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. Journal of Neuroscience 2003, 23:10214-10223.
23. Feltri M.L., D'Antonio M., Quattrini A., et al. A novel P0 glycoprotein transgene activates expression of lacZ in myelin-forming Schwann cells. European Journal of Neuroscience 1999, 11:1577-1586.
24. Finzsch M., Schreiner S., Kichko T., et al. Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. The Journal of Cell Biology 2010, 189:701-712.
25. Finzsch M., Stolt C.C., Lommes P., Wegner M. Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. Development 2008, 135:637-646.
26. Forghani R., Garofalo L., Foran D.R., et al. A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming Schwann cells. Journal of Neuroscience 2001, 21:3780-3787.
27. Ghazvini M., Mandemakers W., Jaegle M., et al. A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. The EMBO Journal 2002, 21:4612-4620.
28. Ghislain J., Charnay P. Control of myelination in Schwann cells: A Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities. EMBO Reports 2006, 7:52-58.
29. Ghislain J., Desmarquet-Trin-Dinh C., Jaegle M., Meijer D., Charnay P., Frain M. Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development. Development 2002, 129:155-166.
30. Girard M., Goossens M. Sumoylation of the SOX10 transcription factor regulates its transcriptional activity. FEBS Letters 2006, 580:1635-1641.
31. Giresi P.G., Kim J., McDaniell R.M., Iyer V.R., Lieb J.D. FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Research 2007, 17:877-885.
32. Hai M., Bidichandani S.I., Patel P.I. Identification of a positive regulatory element in the myelin-specific promoter of the PMP22 gene. Journal of Neuroscience Research 2001, 65:508-519.
33. He Y., Kim J.Y., Dupree J., et al. Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nature Neuroscience 2010, 13:1472-1480.
34. He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W., Rosenfeld M.G. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 1989, 340:35-41.
35. Houlden H., Girard M., Cockerell C., et al. Connexin 32 promoter P2 mutations: A mechanism of peripheral nerve dysfunction. Annals of Neurology 2004, 56:730-734.
36. Howe D.G., McCarthy K.D. Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons. Journal of Neuroscience 2000, 20:3513-3521.
37. Inoue K., Khajavi M., Ohyama T., et al. Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nature Genetics 2004, 36:361-369.
38. Inoue K., Shilo K., Boerkoel C.F., et al. Congenital hypomyelinating neuropathy, central dysmyelination, and Waardenburg-Hirschsprung disease: Phenotypes linked by SOX10 mutation. Annals of Neurology 2002, 52:836-842.
39. Jacob C., Christen C.N., Pereira J.A., et al. HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nature Neuroscience 2011, 14:429-436.
40. Jaegle M., Ghazvini M., Mandemakers W., et al. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes & Development 2003, 17:1380-1391.
41. Jaegle M., Mandemakers W., Broos L., et al. The POU factor Oct-6 and Schwann cell differentiation. Science 1996, 273:507-510.
42. Jagalur N.B., Ghazvini M., Mandemakers W., et al. Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding. Journal of Neuroscience 2011, 31:8585-8594.
43. Jang S.W., Srinivasan R., Jones E.A., et al. Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes. Journal of Neurochemistry 2010, 115:1409-1420.
44. Jang S.W., Svaren J. Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements. Journal of Biological Chemistry 2009, 284:20111-20120.
45. Jessen K.R., Mirsky R. Negative regulation of myelination: Relevance for development, injury, and demyelinating disease. Glia 2008, 56:1552-1565.
46. Jessen K.R., Mirsky R. Control of Schwann cell myelination. F1000 Biology Reports 2010, 2:19.
47. Jones E.A., Jang S.W., Mager G.M., et al. Interactions of Sox10 and Egr2 in myelin gene regulation. Neuron Glia Biology 2007, 3:377-387.
48. Jones E.A., Lopez-Anido C., Srinivasan R., et al. Regulation of the PMP22 gene through an intronic enhancer. Journal of Neuroscience 2011, 31:4242-4250.
49. Kao S.C., Wu H., Xie J., et al. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 2009, 323:651-654.
50. Le N., Nagarajan R., Wang J.Y., Araki T., Schmidt R.E., Milbrandt J. Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:2596-2601.
51. Le N., Nagarajan R., Wang J.Y., et al. Nab proteins are essential for peripheral nervous system myelination. Nature Neuroscience 2005, 8:932-940.
52. LeBlanc S.E., Jang S.W., Ward R.M., Wrabetz L., Svaren J. Direct regulation of myelin protein zero expression by the Egr2 transactivator. Journal of Biological Chemistry 2006, 281:5453-5460.
53. LeBlanc S.E., Ward R.M., Svaren J. Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10. Molecular and Cellular Biology 2007, 27:3521-3529.
54. Lee K.E., Nam S., Cho E.A., et al. Identification of direct regulatory targets of the transcription factor Sox10 based on function and conservation. BMC Genomics 2008, 9:408.
55. Leimeroth R., Lobsiger C., Lussi A., Taylor V., Suter U., Sommer L. Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent progenitor cells. Developmental Biology 2002, 246:245-258.
56. Lemke G., Chao M. Axons regulate Schwann cell expression of the major myelin and NGF receptor genes. Development 1988, 102:499-504.
57. Limpert A.S., Carter B.D. Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation. Journal of Biological Chemistry 2010, 285:16614-16622.
58. Lindsay J., Jiao X., Sakamaki T., et al. ErbB2 induces Notch1 activity and function in breast cancer cells. Clinical and Translational Science 2008, 1:107-115.
59. Maier M., Berger P., Nave K.A., Suter U. Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves. Molecular and Cellular Neurosciences 2002, 20:93-109.
60. Maier M., Castagner F., Berger P., Suter U. Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons. Molecular and Cellular Neurosciences 2003, 24:803-817.
61. Mandemakers W., Zwart R., Jaegle M., et al. A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration. The EMBO Journal 2000, 19:2992-3003.
62. Maurel P., Salzer J.L. Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity. Journal of Neuroscience 2000, 20:4635-4645.
63. Messing A., Behringer R.R., Hammang J.P., Palmiter R.D., Brinster R.L., Lemke G. P0 promoter directs expression of reporter and toxin genes to Schwann cells of transgenic mice. Neuron 1992, 8:507-520.
64. Michailov G.V., Sereda M.W., Brinkmann B.G., et al. Axonal neuregulin-1 regulates myelin sheath thickness. Science 2004, 304:700-703.
65. Miller S.J., Jessen W.J., Mehta T., et al. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Molecular Medicine 2009, 1:236-248.
66. Monje P.V., Soto J., Bacallao K., Wood P.M. Schwann cell dedifferentiation is independent of mitogenic signaling and uncoupled to proliferation: Role of cAMP and JNK in the maintenance of the differentiated state. Journal of Biological Chemistry 2010, 285:31024-31036.
67. Monk K.R., Naylor S.G., Glenn T.D., et al. A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science 2009, 325:1402-1405.
68. Monk K.R., Oshima K., Jors S., Heller S., Talbot W.S. Gpr126 is essential for peripheral nerve development and myelination in mammals. Development 2011, 138:2673-2680.
69. Monuki E.S., Weinmaster G., Kuhn R., Lemke G. SCIP: A glial POU domain gene regulated by cyclic AMP. Neuron 1989, 3:783-793.
70. Murphy P., Topilko P., Schneider-Maunoury S., Seitanidou T., Baron-Van Evercooren A., Charnay P. The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development. Development 1996, 122:2847-2857.
71. Musso M., Balestra P., Taroni F., Bellone E., Mandich P. Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter. Neurobiology of Disease 2003, 12:89-95.
72. Nagarajan R., Svaren J., Le N., Araki T., Watson M., Milbrandt J. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron 2001, 30:355-368.
73. Nave K.A., Salzer J.L. Axonal regulation of myelination by neuregulin 1. Current Opinion in Neurobiology 2006, 16:492-500.
74. Newbern J., Birchmeier C. Nrg1/ErbB signaling networks in Schwann cell development and myelination. Seminars in Cell & Developmental Biology 2010, 21:922-928.
75. Newbern J.M., Li X., Shoemaker S.E., et al. Specific functions for ERK/MAPK signaling during PNS development. Neuron 2011, 69:91-105.
76. Nickols J.C., Valentine W., Kanwal S., Carter B.D. Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation. Nature Neuroscience 2003, 6:161-167.
77. Nishino J., Saunders T.L., Sagane K., Morrison S.J. Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. Journal of Neuroscience 2010, 30:15228-15240.
78. Orfali W., Nicholson R.N., Guiot M.C., Peterson A.C., Snipes G.J. An 8.5-kb segment of the PMP22 promoter responds to loss of axon signals during Wallerian degeneration, but does not respond to specific axonal signals during nerve regeneration. Journal of Neuroscience Research 2005, 80:37-46.
79. Ozkaynak E., Abello G., Jaegle M., et al. Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. Journal of Neuroscience 2010, 30:3857-3864.
80. Parkinson D.B., Bhaskaran A., Arthur-Farraj P., et al. c-Jun is a negative regulator of myelination. The Journal of Cell Biology 2008, 181:625-637.
81. Parkinson D.B., Bhaskaran A., Droggiti A., et al. Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. The Journal of Cell Biology 2004, 164:385-394.
82. Peirano R.I., Goerich D.E., Riethmacher D., Wegner M. Protein zero gene expression is regulated by the glial transcription factor Sox10. Molecular and Cellular Biology 2000, 20:3198-3209.
83. Peirano R.I., Wegner M. The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences. Nucleic Acids Research 2000, 28:3047-3055.
84. Pennuto M., Tinelli E., Malaguti M., et al. Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron 2008, 57:393-405.
85. Pereira J.A., Baumann R., Norrmen C., et al. Dicer in Schwann cells is required for myelination and axonal integrity. Journal of Neuroscience 2010, 30:6763-6775.
86. Prasad M.K., Reed X., Gorkin D.U., et al. SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer. BMC Developmental Biology 2011, 11:40.
87. Reiprich S., Kriesch J., Schreiner S., Wegner M. Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells. Journal of Neurochemistry 2010, 112:744-754.
88. Ryu E.J., Wang J.Y., Le N., et al. Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. Journal of Neuroscience 2007, 27:11552-11559.
89. Saberan-Djoneidi D., Sanguedolce V., Assouline Z., Levy N., Passage E., Fontes M. Molecular dissection of the Schwann cell specific promoter of the PMP22 gene. Gene 2000, 248:223-231.
90. Schlierf B., Ludwig A., Klenovsek K., Wegner M. Cooperative binding of Sox10 to DNA: Requirements and consequences. Nucleic Acids Research 2002, 30:5509-5516.
91. Schreiner S., Cossais F., Fischer K., et al. Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development 2007, 134:3271-3281.
92. Sim F.J., Zhao C., Li W.W., Lakatos A., Franklin R.J. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Molecular and Cellular Neurosciences 2002, 20:669-682.
93. Sock E., Pagon R.A., Keymolen K., Lissens W., Wegner M., Scherer G. Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. Human Molecular Genetics 2003, 12:1439-1447.
94. Stolt C.C., Lommes P., Friedrich R.P., Wegner M. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development 2004, 131:2349-2358.
95. Stolt C.C., Lommes P., Sock E., Chaboissier M.C., Schedl A., Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes & Development 2003, 17:1677-1689.
96. Stolt C.C., Wegner M. SoxE function in vertebrate nervous system development. The International Journal of Biochemistry & Cell Biology 2010, 42:437-440.
97. Suter U., Snipes G.J., Schoener-Scott R., et al. Regulation of tissue-specific expression of alternative peripheral myelin protein-22 (PMP22) gene transcripts by two promoters. Journal of Biological Chemistry 1994, 269:25795-25808.
98. Syed N., Reddy K., Yang D.P., et al. Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination. Journal of Neuroscience 2010, 30:6122-6131.
99. Taveggia C., Pizzagalli A., Fagiani E., Messing A., Feltri M.L., Wrabetz L. Characterization of a Schwann cell enhancer in the myelin basic protein gene. Journal of Neurochemistry 2004, 91:813-824.
100. Taveggia C., Zanazzi G., Petrylak A., et al. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 2005, 47:681-694.
101. Taylor K.M., Labonne C. SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation. Developmental Cell 2005, 9:593-603.
102. Timmerman V., De Jonghe P., Ceuterick C., et al. Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype. Neurology 1999, 52:1827-1832.
103. Topilko P., Schneider-Maunoury S., Levi G., et al. Krox-20 controls myelination in the peripheral nervous system. Nature 1994, 371:796-799.
104. Tuason M.C., Rastikerdar A., Kuhlmann T., et al. Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development. Journal of Neuroscience 2008, 28:6895-6903.
105. Verheijen M.H., Camargo N., Verdier V., et al. SCAP is required for timely and proper myelin membrane synthesis. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:21383-21388.
106. Vigo T., Nobbio L., Hummelen P.V., et al. Experimental Charcot-Marie-Tooth type 1A: A cDNA microarrays analysis. Molecular and Cellular Neurosciences 2005, 28:703-714.
107. Warner L.E., Mancias P., Butler I.J., et al. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nature Genetics 1998, 18:382-384.
108. Werner T., Hammer A., Wahlbuhl M., Bosl M.R., Wegner M. Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Nucleic Acids Research 2007, 35:6526-6538.
109. Weterman M.A., van Ruissen F., de Wissel M., et al. Copy number variation upstream of PMP22 in Charcot-Marie-Tooth disease. European Journal of Human Genetics 2010, 18:421-428.
110. Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Research 2006, 34:1735-1744.
111. Woodhoo A., Alonso M.B., Droggiti A., et al. Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neuroscience 2009, 12:839-847.
112. Yoon C., Korade Z., Carter B.D. Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. Journal of Neuroscience 2008, 28:3738-3746.
113. Yun B., Anderegg A., Menichella D., Wrabetz L., Feltri M.L., Awatramani R. MicroRNA-deficient Schwann cells display congenital hypomyelination. Journal of Neuroscience 2010, 30:7722-7728.
114. Zhang F., Seeman P., Liu P., et al. Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: Rare CNVs as a cause for missing heritability. The American Journal of Human Genetics 2010, 86:892-903.
115. Zorick T.S., Syroid D.E., Arroyo E., Scherer S.S., Lemke G. The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation. Molecular and Cellular Neurosciences 1996, 8:129-145.
116. Zorick T.S., Syroid D.E., Brown A., Gridley T., Lemke G. Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. Development 1999, 126:1397-1406.
117. Zwart R., Broos L., Grosveld G., Meijer D. The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system. Mechanisms of Development 1996, 54:185-194.