HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

Nature Neuroscience

Volumn 14, Issue 4, 2011, Pages 437-441

  Chen, Ying ^a   Wang, Haibo ^a   Yoon, Sung Ok ^b   Xu, Xiaomei ^a   Hottiger, Michael O ^c   Svaren, John ^d   Nave, Klaus A ^e   Kim, Haesun A ^f   Olson, Eric N ^a   Lu, Q Richard ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P300;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DEACETYLATION; ELECTRON MICROSCOPY; GENE DELETION; MOUSE; MUTANT; MYELINATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SCHWANN CELL; SCIATIC NERVE; TRANSCRIPTION REGULATION;

ACETYLATION; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN; E1A-ASSOCIATED P300 PROTEIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; MICE; MICE, KNOCKOUT; NERVE FIBERS, MYELINATED; NF-KAPPA B; RATS; SCHWANN CELLS; SCIATIC NERVE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION;

EID: 79953186033     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2780     Document Type: Article

References (23)

1. Suter, U. & Scherer, S.S. Disease mechanisms in inherited neuropathies. Nat. Rev. Neurosci. 4, 714-726 (2003) (Pubitemid 37280151)
2. Jessen, K.R. & Mirsky, R. The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 6, 671-682 (2005) (Pubitemid 43160316)
3. Svaren, J. & Meijer, D. The molecular machinery of myelin gene transcription in Schwann cells. Glia 56, 1541-1551 (2008)
4. Shahbazian, M.D. & Grunstein, M. Functions of site-specific histone acetylation and deacetylation. Annu. Rev. Biochem. 76, 75-100 (2007)
5. Ye, F. et al. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12, 829-838 (2009)
6. Shen, S. et al. Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat. Neurosci. 11, 1024-1034 (2008)
7. Jaegle, M. et al. The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev. 17, 1380-1391 (2003) (Pubitemid 36666007)
8. Nickols, J.C., Valentine, W., Kanwal, S. & Carter, B.D. Activation of the transcription factor NF-B in Schwann cells is required for peripheral myelin formation. Nat. Neurosci. 6, 161-167 (2003) (Pubitemid 36182785)
9. Calao, M., Burny, A., Quivy, V., Dekoninck, A. & Van Lint, C. A pervasive role of histone acetyltransferases and deacetylases in an NF-B signaling code. Trends Biochem. Sci. 33, 339-349 (2008)
10. Chen, L.F., Mu, Y. & Greene, W.C. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-B. EMBO J. 21, 6539-6548 (2002) (Pubitemid 35448431)
11. Rothgiesser, K.M., Fey, M. & Hottiger, M.O. Acetylation of p65 at lysine 314 is important for late NF-B-dependent gene expression. BMC Genomics 11, 22 (2010)
12. Martin, C. & Zhang, Y. The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell Biol. 6, 838-849 (2005) (Pubitemid 41568733)
13. Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 403, 41-45 (2000) (Pubitemid 30038513)
14. Antonellis, A. et al. Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genet. 4, e1000174 (2008)
15. He, Y. et al. Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nat. Neurosci. 13, 1472-1480 (2010)
16. Fancy, S.P. et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 23, 1571-1585 (2009)
17. Jacob, C. et al. HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat. Neurosci. published online, doi:10.1038/nn.2762 (20 March 2011).
18. Harada, N. et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18, 5931-5942 (1999) (Pubitemid 29515670)
19. Chen, Y. et al. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat. Neurosci. 12, 1398-1406 (2009)
20. Brockes, J.P., Fields, K.L. & Raff, M.C. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res. 165, 105-118 (1979) (Pubitemid 9148699)
21. Yeiser, E.C., Rutkoski, N.J., Naito, A., Inoue, J. & Carter, B.D. Neurotrophin signaling through the p75 receptor is deficient in traf6/ mice. J. Neurosci. 24, 10521-10529 (2004) (Pubitemid 39552637)
22. Jang, S.W., LeBlanc, S.E., Roopra, A., Wrabetz, L. & Svaren, J. In vivo detection of Egr2 binding to target genes during peripheral nerve myelination. J. Neurochem. 98, 1678-1687 (2006) (Pubitemid 44200456)
23. Bernstein, B.E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).