메뉴 건너뛰기




Volumn 6, Issue 5, 2014, Pages 1350-1365

Optimization of biopolymer based transdermal films of metoclopramide as an alternative delivery approach

Author keywords

Antiemetic drug; Metoclopramide; Natural polymers; Sodium alginate; Terpenes; Transdermal film

Indexed keywords

FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIPID BILAYERS; NATURAL POLYMERS; PATIENT TREATMENT; TERPENES;

EID: 84901983982     PISSN: None     EISSN: 20734360     Source Type: Journal    
DOI: 10.3390/polym6051350     Document Type: Article
Times cited : (22)

References (53)
  • 2
  • 3
    • 47949099340 scopus 로고    scopus 로고
    • Matrix-type transdermal patches of verapamil hydrochloride: In vitro permeation studies through excised rat skin and pharmacodynamic evaluation in rats
    • Güngör, S.; Bektaş, A.; Alp, F.I.; Uydeş-Doǧan, B.S.; Ozdemir, O.; Araman, A.; Özsoy, Y. Matrix-type transdermal patches of verapamil hydrochloride: In vitro permeation studies through excised rat skin and pharmacodynamic evaluation in rats. Pharm. Dev. Technol. 2008, 13, 283-289.
    • (2008) Pharm. Dev. Technol. , vol.13 , pp. 283-289
    • Güngör, S.1    Bektaş, A.2    Alp, F.I.3    Uydeş-Doǧan, B.S.4    Ozdemir, O.5    Araman A.6    Özsoy, Y.7
  • 4
    • 84878329753 scopus 로고    scopus 로고
    • Optimization and characterization of chitosan films for transdermal delivery of ondansetron
    • Can, S.; Erdal, M.S.; Güngör, S.; Özsoy, Y. Optimization and characterization of chitosan films for transdermal delivery of ondansetron. Molecules 2013, 18, 5455-5471.
    • (2013) Molecules , vol.18 , pp. 5455-5471
    • Can, S.1    Erdal, M.S.2    Güngör, S.3    Özsoy, Y.4
  • 5
    • 84901988143 scopus 로고    scopus 로고
    • Design and evaluation of polysaccharide-based transdermal films for the controlled delivery of nifedipine
    • Bektaş, A.; Cevher, E.; Güngör, S.; Özsoy, Y. Design and evaluation of polysaccharide-based transdermal films for the controlled delivery of nifedipine. Chem. Pharm. Bull. 2014, 6, 1-9.
    • (2014) Chem. Pharm. Bull. , vol.6 , pp. 1-9
    • Bektaş, A.1    Cevher, E.2    Güngör, S.3    Özsoy, Y.4
  • 6
    • 0003074726 scopus 로고    scopus 로고
    • Polysaccharide based polymers in cosmetics
    • In, Goddard, E.D., Gruber, J.V., Eds.; Marcel Dekker Inc.: New York, NY, USA
    • Gruber, J.W. Polysaccharide based polymers in cosmetics. In Principles of Polymer Science and Technology in Cosmetics and Personal Care; Goddard, E.D., Gruber, J.V., Eds.; Marcel Dekker Inc.: New York, NY, USA, 1999; pp. 339-402.
    • (1999) Principles of Polymer Science and Technology in Cosmetics and Personal Care , pp. 339-402
    • Gruber, J.W.1
  • 8
    • 77149166351 scopus 로고    scopus 로고
    • Bioadhesive polymeric platforms for transmucosal drug delivery systems-A review
    • Roy, S.K.; Prabhakar, B. Bioadhesive polymeric platforms for transmucosal drug delivery systems-A review. Trop. J. Pharm. Res. 2010, 9, 91-104.
    • (2010) Trop. J. Pharm. Res. , vol.9 , pp. 91-104
    • Roy, S.K.1    Prabhakar, B.2
  • 10
    • 0030881710 scopus 로고    scopus 로고
    • Skin permeation of parabens in excised guinea pig dorsal skin, its modification by penetration enhancers and their relationship with n-octanol/water partition coefficients
    • Kitagawa, S.; Li, H.; Sato, S. Skin permeation of parabens in excised guinea pig dorsal skin, its modification by penetration enhancers and their relationship with n-octanol/water partition coefficients. Chem. Pharm. Bull. 1997, 45, 1354-1357.
    • (1997) Chem. Pharm. Bull. , vol.45 , pp. 1354-1357
    • Kitagawa, S.1    Li, H.2    Sato, S.3
  • 11
    • 79958142662 scopus 로고    scopus 로고
    • Optimized preparation and evaluation of indomethacin transdermal patch
    • Li, T.; Ren, C.; Wang, M.; Zhao, L.; Wang, X.; Fang, L. Optimized preparation and evaluation of indomethacin transdermal patch. Asian J. Pharm. Sci. 2007, 2, 249-259.
    • (2007) Asian J. Pharm. Sci. , vol.2 , pp. 249-259
    • Li, T.1    Ren, C.2    Wang, M.3    Zhao, L.4    Wang, X.5    Fang, L.6
  • 12
    • 45849091873 scopus 로고    scopus 로고
    • Studies on optimizing in vitro transdermal permeation of ondansetron hydrochloride using nerodilol, carvone, and limonene as penetration enhancers
    • Krisnaiah, Y.S.R.; Raju, V.; Kumar, M.S.; Rama, B.; Raghumurthy, V.; Ramana Murthy, K.V. Studies on optimizing in vitro transdermal permeation of ondansetron hydrochloride using nerodilol, carvone, and limonene as penetration enhancers. Pharm. Dev. Technol. 2008, 13, 177-185.
    • (2008) Pharm. Dev. Technol. , vol.13 , pp. 177-185
    • Krisnaiah, Y.S.R.1    Raju, V.2    Kumar, M.S.3    Rama, B.4    Raghumurthy, V.5    Ramana Murthy, K.V.6
  • 13
    • 24744468374 scopus 로고    scopus 로고
    • In vivo skin permeation of sodium naproxen formulated in pluronic F-127 gels: Effect of Azone and Transcutol
    • Escobar-Chavez, J.J.; Quintanar-Guerrero, D.; Ganem-Quintanar, A. In vivo skin permeation of sodium naproxen formulated in pluronic F-127 gels: Effect of Azone and Transcutol. Drug Dev. Ind. Pharm. 2005, 31, 447-454.
    • (2005) Drug Dev. Ind. Pharm. , vol.31 , pp. 447-454
    • Escobar-Chavez, J.J.1    Quintanar-Guerrero, D.2    Ganem-Quintanar, A.3
  • 14
    • 17844373273 scopus 로고    scopus 로고
    • Transdermal drug delivery: Penetration enhancement techniques
    • Benson, H.A.E. Transdermal drug delivery: Penetration enhancement techniques. Curr. Drug Deliv. 2005, 2, 23-33.
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 23-33
    • Benson, H.A.E.1
  • 15
    • 0027930323 scopus 로고
    • Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers
    • Levison, K.K.; Takayama, K.; Isowa, K.; Okabe, K.; Nagai, T. Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers. J. Pharm. Sci. 1994, 83, 1367-1372.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1367-1372
    • Levison, K.K.1    Takayama, K.2    Isowa, K.3    Okabe, K.4    Nagai, T.5
  • 16
    • 36549004085 scopus 로고    scopus 로고
    • Status of terpenes as skin penetration enhancers
    • Aqil, M.; Ahad, A.; Sultana, Y.; Ali, A. Status of terpenes as skin penetration enhancers. Drug Discov. Today 2007, 12, 1061-1067.
    • (2007) Drug Discov. Today , vol.12 , pp. 1061-1067
    • Aqil, M.1    Ahad, A.2    Sultana, Y.3    Ali, A.4
  • 17
    • 34447318327 scopus 로고    scopus 로고
    • Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin
    • Kang, L.; Yap, C.W.; Lim, P.F.C.; Chen, Y.Z.; Ho, P.C.; Chan, Y.W., Wong, G.P.; Chan, S.Y. Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin. J. Control. Release 2007, 120, 211-219.
    • (2007) J. Control. Release , vol.120 , pp. 211-219
    • Kang, L.1    Yap, C.W.2    Lim, P.F.C.3    Chen, Y.Z.4    Ho, P.C.5    Chan, Y.W.6    Wong, G.P.7    Chan, S.Y.8
  • 18
    • 45849144396 scopus 로고    scopus 로고
    • Transdermal delivery of valsartan: I. Effect of various terpenes
    • Rizwan, M.; Aqil, M.; Ahad, A.; Sultana, Y.; Ali, M.M. Transdermal delivery of valsartan: I. Effect of various terpenes. Drug Dev. Ind. Pharm. 2008, 34, 618-626.
    • (2008) Drug Dev. Ind. Pharm. , vol.34 , pp. 618-626
    • Rizwan, M.1    Aqil, M.2    Ahad, A.3    Sultana, Y.4    Ali, M.M.5
  • 19
    • 32044459120 scopus 로고    scopus 로고
    • Molecular interactions between the penetration enhancer 1,8-cineole and human skin
    • Williams, A.C.; Edwards, H.G.M.; Lawson, E.E.; Barry, B.W. Molecular interactions between the penetration enhancer 1,8-cineole and human skin. J. Raman Spectrosc. 2006, 37, 361-366.
    • (2006) J. Raman Spectrosc. , vol.37 , pp. 361-366
    • Williams, A.C.1    Edwards, H.G.M.2    Lawson, E.E.3    Barry, B.W.4
  • 20
    • 33644990077 scopus 로고    scopus 로고
    • Thermotropic and spectroscopic behavior of skin: Relationship with percutaneous permeation enhancement
    • Babita, K.; Kumar, V.; Rana, V.; Jain, S.; Tiwory, A.K. Thermotropic and spectroscopic behavior of skin: Relationship with percutaneous permeation enhancement. Curr. Drug Deliv. 2006, 3, 95-113.
    • (2006) Curr. Drug Deliv. , vol.3 , pp. 95-113
    • Babita, K.1    Kumar, V.2    Rana, V.3    Jain, S.4    Tiwory, A.K.5
  • 21
    • 34648812680 scopus 로고    scopus 로고
    • The effect of mixed-solvent and terpenes on percutaneous absorption of meloxicam gel
    • Chang, J.S.; Tsai, Y.H.; Wu, P.C.; Huang, Y.B. The effect of mixed-solvent and terpenes on percutaneous absorption of meloxicam gel. Drug Dev. Ind. Pharm. 2007, 33, 984-989.
    • (2007) Drug Dev. Ind. Pharm. , vol.33 , pp. 984-989
    • Chang, J.S.1    Tsai, Y.H.2    Wu, P.C.3    Huang, Y.B.4
  • 22
    • 0025961840 scopus 로고
    • Terpenes and the lipid-protein partition theory of skin penetration enhancement
    • Williams, A.C.; Barry, B.W. Terpenes and the lipid-protein partition theory of skin penetration enhancement. Pharm. Res. 1991, 8, 17-24.
    • (1991) Pharm. Res. , vol.8 , pp. 17-24
    • Williams, A.C.1    Barry, B.W.2
  • 23
    • 0025858199 scopus 로고
    • The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs
    • Williams, A.C.; Barry, B.W. The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs. Int. J. Pharm. 1991, 74, 157-168.
    • (1991) Int. J. Pharm. , vol.74 , pp. 157-168
    • Williams, A.C.1    Barry, B.W.2
  • 24
    • 0031693193 scopus 로고    scopus 로고
    • Enhancement by terpenes of 5-fluororuracil permeation through the stratum corneum: model solvent approach
    • Moghimi, H.R.; Williams, A.C.; Barry, B.W. Enhancement by terpenes of 5-fluororuracil permeation through the stratum corneum: model solvent approach. J. Pharm. Pharmacol. 1998, 50, 955-964.
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 955-964
    • Moghimi, H.R.1    Williams, A.C.2    Barry, B.W.3
  • 25
    • 0026033106 scopus 로고
    • Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: Effect of enhancer lipophilicity
    • Hori, M.; Satoh, S.; Maibach, H.I.; Guy, R.H. Enhancement of propranolol hydrochloride and diazepam skin absorption in vitro: Effect of enhancer lipophilicity. J. Pharm. Sci. 1991, 80, 32-35.
    • (1991) J. Pharm. Sci. , vol.80 , pp. 32-35
    • Hori, M.1    Satoh, S.2    Maibach, H.I.3    Guy, R.H.4
  • 26
    • 33751042889 scopus 로고    scopus 로고
    • Rapid-onset intranasal delivery of metoclopramide hydrochloride. Part I. Influence of formulation variables on drug absorption in anesthetized rats
    • Zaki, N.M.; Awaad, G.A.S.; Mortada, N.M.; Abd El Hady, S.S. Rapid-onset intranasal delivery of metoclopramide hydrochloride. Part I. Influence of formulation variables on drug absorption in anesthetized rats. Int. J. Pharm. 2006, 327, 89-96.
    • (2006) Int. J. Pharm. , vol.327 , pp. 89-96
    • Zaki, N.M.1    Awaad, G.A.S.2    Mortada, N.M.3    Abd El Hady, S.S.4
  • 27
    • 33751030524 scopus 로고    scopus 로고
    • Rapid-onset intranasal delivery of metoclopramide hydrochloride Part II: Safety of various absorption enhancers and pharmacokinetic evaluation
    • Zaki, N.M.; Mortada, N.M.; Awaad, G.A.S.; Abd El Hady, S.S. Rapid-onset intranasal delivery of metoclopramide hydrochloride Part II: Safety of various absorption enhancers and pharmacokinetic evaluation. Int. J. Pharm. 2006, 327, 97-103.
    • (2006) Int. J. Pharm. , vol.327 , pp. 97-103
    • Zaki, N.M.1    Mortada, N.M.2    Awaad, G.A.S.3    Abd El Hady, S.S.4
  • 28
    • 77956921003 scopus 로고
    • Metoclopramide hydrochloride
    • In, Florey, K., Ed.; Academic Press: San Diego, CA, USA
    • Pitrè, D.; Stradi, R. Metoclopramide hydrochloride. In Analytical Profiles of Drug Substances, Florey, K., Ed.; Academic Press: San Diego, CA, USA, 1987; Volume 16, pp. 327-360.
    • (1987) Analytical Profiles of Drug Substances , vol.16 , pp. 327-360
    • Pitrè, D.1    Stradi, R.2
  • 30
    • 57149144115 scopus 로고    scopus 로고
    • Effect of thiolated polymers to textural and mucoadhesive properties of vaginal gel formulations prepared with polycarbophil and chitosan
    • Cevher, E.; Sensoy, D.; Taha, M.A.M. Effect of thiolated polymers to textural and mucoadhesive properties of vaginal gel formulations prepared with polycarbophil and chitosan. AAPS PharmSciTech 2008, 9, 953-965.
    • (2008) AAPS PharmSciTech , vol.9 , pp. 953-965
    • Cevher, E.1    Sensoy, D.2    Taha, M.A.M.3
  • 31
    • 0033050183 scopus 로고    scopus 로고
    • Physicochemical characterization and preliminary in vivo efficiacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis
    • Jones, D.S.; Irwin, C.R.; Woolfson, A.D.; Djokic, J.; Adams, V. Physicochemical characterization and preliminary in vivo efficiacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis. J. Pharm. Sci. 1999, 88, 592-598.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 592-598
    • Jones, D.S.1    Irwin, C.R.2    Woolfson, A.D.3    Djokic, J.4    Adams, V.5
  • 32
    • 0344893332 scopus 로고
    • Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
    • Higuchi, T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 1963, 52, 1145-1149.
    • (1963) J. Pharm. Sci. , vol.52 , pp. 1145-1149
    • Higuchi, T.1
  • 33
    • 0025009106 scopus 로고
    • Examination of stratum corneum barrier function in vivo by infrared spectroscopy
    • Bommannan, D.; Potts, R.O.; Guy, R.H. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J. Investig. Dermatol. 1990, 95, 403-408.
    • (1990) J. Investig. Dermatol. , vol.95 , pp. 403-408
    • Bommannan, D.1    Potts, R.O.2    Guy, R.H.3
  • 34
    • 84872162539 scopus 로고    scopus 로고
    • In vivo barrier challenge and initial recovery in human facial skin
    • Gorcea, M.; Hadgraft, J.; Moore, D.J.; Lane, M.E. In vivo barrier challenge and initial recovery in human facial skin. Skin Res. Technol. 2013, 19, e375-e382.
    • (2013) Skin Res. Technol. , vol.19
    • Gorcea, M.1    Hadgraft, J.2    Moore, D.J.3    Lane, M.E.4
  • 35
    • 77950917414 scopus 로고    scopus 로고
    • Design and formulation of mebeverine HCl semisolid formulations for intraorally administration
    • Baloǧlu, E.; Karavana, S.Y.; Hysein, I.Y.; Köse, T. Design and formulation of mebeverine HCl semisolid formulations for intraorally administration. AAPS PharmSciTech 2010, 11, 181-188.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 181-188
    • Baloǧlu, E.1    Karavana, S.Y.2    Hysein, I.Y.3    Köse, T.4
  • 36
    • 0030469411 scopus 로고    scopus 로고
    • Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases
    • Jones, D.S.; Woolfson, A.D.; Djokic, J.; Coulter, W.A. Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm. Res. 1996, 13, 1734-1738.
    • (1996) Pharm. Res. , vol.13 , pp. 1734-1738
    • Jones, D.S.1    Woolfson, A.D.2    Djokic, J.3    Coulter, W.A.4
  • 37
    • 38149103499 scopus 로고    scopus 로고
    • Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives
    • Cevher, E.; Taha, M.A.M.; Orlu, M.; Araman, A. Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives. Drug Deliv. 2008, 15, 57-67.
    • (2008) Drug Deliv. , vol.15 , pp. 57-67
    • Cevher, E.1    Taha, M.A.M.2    Orlu, M.3    Araman, A.4
  • 38
    • 0030766318 scopus 로고    scopus 로고
    • Mucoadhesive, syringeable drug delivery systems for controlled application of metronidazole to the periodontal pocket: In vitro release kinetics, syringeability, mechanical and mucoadhesive properties
    • Jones, D.S.; Woolfson, A.D.; Brown, A.F.; O'Neill, M.J. Mucoadhesive, syringeable drug delivery systems for controlled application of metronidazole to the periodontal pocket: In vitro release kinetics, syringeability, mechanical and mucoadhesive properties. J. Control. Release 1997, 49, 71-79.
    • (1997) J. Control. Release , vol.49 , pp. 71-79
    • Jones, D.S.1    Woolfson, A.D.2    Brown, A.F.3    O'Neill, M.J.4
  • 39
    • 84902005291 scopus 로고    scopus 로고
    • 31, 26th ed.; U.S. Pharmacopeial Convention: Twinbrook Parkway, Rockwille, MD, USA
    • The United States Pharmacopeia 31, 26th ed.; U.S. Pharmacopeial Convention: Twinbrook Parkway, Rockwille, MD, USA, 2008; p. 683.
    • (2008) The United States Pharmacopeia , pp. 683
  • 40
    • 77954540452 scopus 로고    scopus 로고
    • Adhesion testing of transdermal matrix patches with a probe tack test-In vitro and in vivo evaluation
    • Gutschke, E.; Bracht, S.; Nagel, S.; Weitschies, W. Adhesion testing of transdermal matrix patches with a probe tack test-In vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 2010, 75, 399-404.
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , pp. 399-404
    • Gutschke, E.1    Bracht, S.2    Nagel, S.3    Weitschies, W.4
  • 41
    • 33746658667 scopus 로고    scopus 로고
    • Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute
    • Wokovich, A.M.; Prodduturi, S.; Doub, W.H.; Hussain, A.S.; Buhse, L.F. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eur. J. Pharm. Biopharm. 2006, 64, 1-8.
    • (2006) Eur. J. Pharm. Biopharm. , vol.64 , pp. 1-8
    • Wokovich, A.M.1    Prodduturi, S.2    Doub, W.H.3    Hussain, A.S.4    Buhse, L.F.5
  • 42
    • 84878312147 scopus 로고    scopus 로고
    • Plasticizers in Transdermal Drug Delivery Systems
    • In, Luqman, M., Ed.; InTech: Rijeka, Croatia
    • Güngör, S.; Erdal, M.S.; Özsoy, Y. Plasticizers in Transdermal Drug Delivery Systems. In Recent Advances in Plasticizers; Luqman, M., Ed.; InTech: Rijeka, Croatia, 2012; pp. 91-112.
    • (2012) Recent Advances in Plasticizers , pp. 91-112
    • Güngör, S.1    Erdal, M.S.2    Özsoy, Y.3
  • 43
    • 0035073301 scopus 로고    scopus 로고
    • Modeling and comparison of dissolution profiles
    • Costa, P.; Lobo, S.J.M. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 2001, 13, 123-133.
    • (2001) Eur. J. Pharm. Sci. , vol.13 , pp. 123-133
    • Costa, P.1    Lobo, S.J.M.2
  • 44
    • 50849131904 scopus 로고    scopus 로고
    • Development and in vitro evaluation of transdermal matrix films of metoprolol tartrate
    • Bhatt, D.C.; Dhake, A.S.; Khar, R.K.; Mishra, D.N. Development and in vitro evaluation of transdermal matrix films of metoprolol tartrate. Yakugaku Zasshi. 2008, 128, 1325-1331.
    • (2008) Yakugaku Zasshi. , vol.128 , pp. 1325-1331
    • Bhatt, D.C.1    Dhake, A.S.2    Khar, R.K.3    Mishra, D.N.4
  • 45
    • 77949768150 scopus 로고    scopus 로고
    • Development of matrix type transdermal patches of lercanidipine hydrochloride: physicochemical and in vitro characterization
    • Mamatha, T.; Venkateswara Rao, J.; Mukkanti, K.; Ramesh, G. Development of matrix type transdermal patches of lercanidipine hydrochloride: physicochemical and in vitro characterization. Daru. J. Pharm. Sci. 2010, 18, 9-16.
    • (2010) Daru. J. Pharm. Sci. , vol.18 , pp. 9-16
    • Mamatha, T.1    Venkateswara Rao, J.2    Mukkanti, K.3    Ramesh, G.4
  • 46
    • 77955355453 scopus 로고    scopus 로고
    • Transdermal therapeutic system of isradipine: Effect of hydrophilic and hydrophobic matrix on in vitro and ex vivo characteristics
    • Tirunagari, M.; Jangala, V.R.; Khagga, M.; Gannu, R. Transdermal therapeutic system of isradipine: Effect of hydrophilic and hydrophobic matrix on in vitro and ex vivo characteristics. Arch. Pharm. Res. 2010, 33, 1025-1033.
    • (2010) Arch. Pharm. Res. , vol.33 , pp. 1025-1033
    • Tirunagari, M.1    Jangala, V.R.2    Khagga, M.3    Gannu, R.4
  • 48
    • 0033812031 scopus 로고    scopus 로고
    • Mechanism(s) of in vitro percutaneous absorption enhancement of Tamoxifen by Enhancers
    • Zhao, K.; Singh, J. Mechanism(s) of in vitro percutaneous absorption enhancement of Tamoxifen by Enhancers. J. Pharm. Sci. 2000, 89, 771-780.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 771-780
    • Zhao, K.1    Singh, J.2
  • 50
    • 84885939265 scopus 로고    scopus 로고
    • Impacts of chemical enhancers on skin permeation and deposition of terbinafine
    • Erdal, M.S.; Peköz Yi{dotless}ldi{dotless}z, A.; Aksu, B.; Araman, A. Impacts of chemical enhancers on skin permeation and deposition of terbinafine. Pharm. Dev. Technol. 2014, 19, 565-570.
    • (2014) Pharm. Dev. Technol. , vol.19 , pp. 565-570
    • Erdal, M.S.1    Peköz Yildiz, A.2    Aksu, B.3    Araman, A.4
  • 51
    • 0031722003 scopus 로고    scopus 로고
    • Mechanisms of percutaneous absorption of tamoxifen by terpenes: Eugenol, d-limonene and menthone
    • Zhao, K.; Singh, J. Mechanisms of percutaneous absorption of tamoxifen by terpenes: Eugenol, d-limonene and menthone. J. Control. Rel. 1998, 55, 253-260.
    • (1998) J. Control. Rel. , vol.55 , pp. 253-260
    • Zhao, K.1    Singh, J.2
  • 52
    • 0035850210 scopus 로고    scopus 로고
    • Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin
    • Takahashi, K.; Sakano, H.; Yoshida, M.; Numata, N.; Mizuno, N. Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin. J. Control. Rel. 2001, 73, 351-358.
    • (2001) J. Control. Rel. , vol.73 , pp. 351-358
    • Takahashi, K.1    Sakano, H.2    Yoshida, M.3    Numata, N.4    Mizuno, N.5
  • 53
    • 0037448407 scopus 로고    scopus 로고
    • Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels
    • Fang, J.Y.; Hwang, T.L.; Leu, Y.L. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int. J. Pharm. 2003, 250, 313-325.
    • (2003) Int. J. Pharm. , vol.250 , pp. 313-325
    • Fang, J.Y.1    Hwang, T.L.2    Leu, Y.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.