Matrix-type transdermal patches of verapamil hydrochloride: In vitro permeation studies through excised rat skin and pharmacodynamic evaluation in rats

Pharmaceutical Development and Technology

Volumn 13, Issue 4, 2008, Pages 283-289

  Güngör, Sevgi ^a   Bektaş, Ayşegül ^a   Alp, F Ilkay ^a   Uydeş Doǧan, B Sönmez ^a   Özdemir, Osman ^a   Araman, Ahmet ^a   Özsoy, Yildiz ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Pectin; Percutaneous absorption; Terpene; Transdermal patch; Verapamil hydrochloride

Indexed keywords

CINEOLE; LIMONENE; MENTHOL; MENTHONE; NEROLIDOL; PECTIN; PLASTICIZER; PROPYLENE GLYCOL; TERPENE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PENETRATION; SYSTOLIC BLOOD PRESSURE;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; EXCIPIENTS; FEMALE; MALE; PECTINS; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; TERPENES; TIME FACTORS; VERAPAMIL;

EID: 47949099340     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802088851     Document Type: Article

References (35)

1. Hardman JG, Limbird LE, Malinoff PB, Ruddon RW. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. London: McGraw-Hill; 1996.
2. Sweetman SC. Martindale. The Complete Drug Reference. 33rd ed. London: Pharmaceutical Press; 2002:989-992.
3. Shah HS, Tojo K, Huang YC, Chien YW. Development and clinical evaluation of a verapamil transdermal delivery system. J Control Release. 1992;22:125-132.
4. Tenjarla SN, Allen R, Borazani A. Evaluation of verapamil hydrochloride permeation through human cadaver skin. Drug Dev Ind Pharm. 1994;20:49-63.
5. Jain AK, Thomas NS, Panchagnula R. Transdermal drug delivery of imipramine hydrochloride: I. Effect of terpenes. J Control Release. 2002;79:93-101.
6. Kusum Devi V, Saisivam S, Maria GR, Deepti PU. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm. 2003;29:495-503.
7. Sugibayashi K, Morimoto Y. Polymers for transdermal drug delivery systems. J Control Release. 1994;29:177-185.
8. Ladenheim D, Martin GP, Marriott C, Hollingsbee DA, Brown MB. An in-vitro study of the effect of hydrocolloid patch occlusion on the penetration of triamcinolone acetonide through skin in man. J Pharm Pharmacol. 1996;48:806-811.
9. Martin GP, Ladenheim D, Marriott C, Hollingsbee DA, Brown MB. The influence of hydrocolloid patch composition on the bioavailability of triamcinolone acetonide in humans. Drug Dev Ind Pharm. 2000;26:35-43.
10. Bektaş A, Özsoy Y. Investigations on preparing matrix-type transdermal patches of nifedipine with natural polymers. Acta Pharm Turcica. 2004;46(suppl. 2004):126.
11. Williams AC, Barry BW. Penetration enhancers. Adv Drug Del Rev. 2004;56:603-618.
12. Megrab NA, Williams AC, Barry BW. Oestradiol permeation accross human skin, silastic and snake skin membranes: the effects of ethanol/water co-solvent systems. Int J Pharm. 1995;116:101-112.
13. Gungor S, Bergisadi N. Effect of penetration enhancers on in vitro percutaneous penetration of nimesulide through rat skin. Pharmazie. 2004;59:39-41.
14. Afouna MI, Fincher TK, Zaghloul AAA, Reddy IK. Effect of Azone® upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice. Int J Pharm. 2003;253:159-168.
15. Amnuaikit C, Ikeuchi I, Ogawara K, Higaki K, Kimura T. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. Int J Pharm. 2005;289:167-178.
16. Williams AC, Barry BW. The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs. Int J Pharm. 1991;74:157-168.
17. Monti D, Chetoni P, Burgalassi S, Najarro M, Saettone MF, Boldrini E. Effect of different terpene-containing essential oils on permeation of eastrodiol through hairless mouse skin. Int J Pharm. 2002;237:209-214.
18. Cornwell PA, Barry BW. Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil. J Pharm Pharmacol. 1994;46:261-269.
19. Jain GK, Sharma AK, Agrawal SS. Transdermal controlled administration of verapamil-enhancement of skin permeability. Int J Pharm. 1996;130:169-177.
20. Laffan RJ, Peterson, A, Hitch SW, Jeunelot C. A technique for prolonged, continuous recording of blood pressure of unrestrained rats. Cardiovasc Res. 1972;6:319-324.
21. Barry BW. Dermatological Formulations. New York, NY: Marcel Dekker; 1983.
22. Ghosh TK, Pfister W, Yum SI. Transdermal and Topical Drug Delivery Systems. Buffalo Grove, IL, USA: Interpharm Press Inc; 1997.
23. The United States Pharmacopeia 28/National Formulary 23, United States Pharmacopeial Convention, Inc, Rockwell, MD; 2005.
24. Gao S, Singh J. Mechanism of transdermal transport of 5-fluorouracil by terpenes: carvone, 1,8-cineole and thymol. Int J Pharm. 1997;154:67-77.
25. Arellano A, Santoyo S, Martin C, Ygartua P. Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium. Int J Pharm. 1996;130:141-145.
26. El-Kattan AF, Asbill CS, Kim N, Michniak BB. The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities. Int J Pharm. 2001;215:229-240.
27. Moghimi HR, Williams AC, Barry BW. A lamellar matrix model for stratum corneum intercelular lipids. V. Effects of terpen penetration enhancers on the structure and thermal behaviour of the matrix. Int J Pharm. 1997;146:41-54.
28. Krishnaiah YSR, Al-Saidan SM, Jayaram B. Effect of nerolidol, carvone and anethole on the in vitro transdermal delivery of selegiline hydrochloride. Pharmazie. 2005;61: 46-53.
29. Chowhan ZT, Pritchard R. Effect of surfactants on percutaneous absorption of naproxen I: comparisons of rabbit, rat, and human excised skin. J Pharm Sci. 1978;67: 1272-1274.
30. Narishetty STK, Panchagnula R. Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action. J Control Release. 2004;95:367-379.
31. Diez I, Colom H, Moreno J, Obach R, Perasre C, Domenech J. A comparative in vitro study of transdermal absorption of a serious of calcium channel antagonists. J Pharm Sci. 1991;80:931-934.
32. Bolgül Y, Hekimoglu S, Şahin-Erdemli I, Kaş HS. Evaluation of oxprenolol hydrochloride permeation through isolated human skin and pharmacodynamic effect in rats. STP Pharm Sci. 1998;8:197-201.
33. Wu PC, Huang YB, Chang JJF, Chang JS, Tsai YH. Evaluation of pharmacokinetics and pharmacodynamics of captopril from transdermal hydrophilic gels in normotensive rabbits and spontaneously hypertensive rats. Int J Pharm. 2000;209:87-94.
34. Zakzewski CA, Li JK. Pulsed mode constant current iontophoretic transdermal metoprolol tartarate delivery in established acute hypertensive rabbits. J Control Release. 1991;17:157-162.
35. Kemken J, Ziegler A, Müller BW. Investigations into the pharmacodynamic effects of dermally administered microemulsions containing β-blokers. J Pharm Pharmacol. 1991;43:679-684.