Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin

Journal of Controlled Release

Volumn 120, Issue 3, 2007, Pages 211-219

  Kang, L ^a   Yap, C W ^a   Lim, P F C ^a   Chen, Y Z ^a   Ho, P C ^a   Chan, Y W ^b   Wong, G P ^a   Chan, S Y ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Human skin; In vitro permeation; Penetration enhancement; Quantitative Structure Activity Relationship (QSAR); Quantitative Structure Property Relationship (QSPR); Terpenes

Indexed keywords

HUMAN SKIN; IN VITRO PERMEATION; PENETRATION ENHANCEMENT; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR); QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIP (QSPR); TERPENES;

ALDEHYDES; DRUG PRODUCTS; GLYCOLS; LINEAR REGRESSION; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PROPYLENE;

HYDROCARBONS;

ABSINTHOL; ALDEHYDE; ALPHA CEDRENE; ALPHA SANTONIN; AROMADENDRENE; BISABOLOL; CARVEOL; CARVONE; CARYOPHYLLENE; CARYOPHYLLENE OXIDE; CEDRENE; CEDROL; CEDRYL ACETATE; DIHYDROCARVEOL; DIHYDROCARVONE; EPIGLOBULOL; ESTER; GUAIOL; HALOPERIDOL; ISOLONGIFOLOL; ISOPULEGOL; LINALOOL; LONGIFOLENE; MYRTENAL; MYRTENOL; NEROLIDOL; PROPYLENE GLYCOL; TERPENE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR WEIGHT; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; REGRESSION ANALYSIS; ROOM TEMPERATURE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, CUTANEOUS; CELL MEMBRANE PERMEABILITY; EPIDERMIS; FEMALE; HUMANS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; SKIN ABSORPTION; TERPENES;

EID: 34447318327     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.05.006     Document Type: Article

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