Naturapolyceutics: The science of utilizing natural polymers for drug delivery

Polymers

Volumn 6, Issue 5, 2014, Pages 1312-1332

  Ngwuluka, Ndidi C ^a   Ochekpe, Nelson A ^a   Aruoma, Okezie I ^b  

^a UNIVERSITY OF JOS   (Nigeria)

^b American University of Health Sciences   (United States)

Author keywords

Biogenic; Drug delivery; Drug delivery systems; Gum; Mucilage; Natural polymer; Naturapolyceutics; Polymer modification; Polymers; Polysaccharide

Indexed keywords

DRUG DELIVERY; POLYMERS; POLYSACCHARIDES;

BIOGENIC; DRUG DELIVERY SYSTEM; GUM; MUCILAGE; NATURAPOLYCEUTICS; POLYMER MODIFICATIONS;

NATURAL POLYMERS;

EID: 84901983639     PISSN: None     EISSN: 20734360     Source Type: Journal    
DOI: 10.3390/polym6051312     Document Type: Review

References (79)

1. Beneke, C.E.; Viljoen, A.M.; Hamman, J.H. Polymericplant-derived excipients in drug delivery. Molecules 2009, 14, 2602-2620.
2. Pillai, O.; Panchagnula, R. Polymersin drug delivery. Curr. Opin. Chem. Biol. 2001, 5, 447-451.
3. Ngwuluka, N.C.; Akanbi, M.; Agboyo, I.; Uwaezuoke, O.J. Characterizationof gum from Sesamum indicum leaves as a suspending agent in a pediatric pharmaceutical suspension. WJPR 2012, 1, 909-924.
4. Sonia, T.A.; Sharma, C.P. Anoverview of natural polymers for oral insulin delivery. Drug Discov. Today 2012, 17, 784-792.
5. Malafaya, P.B.; Silva, G.A.; Reis, R.L. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv. Drug Deliv. Rev. 2007, 59, 207-233.
6. Ngwuluka, N.C.; Kyari, J.; Taplong, J.; Uwaezuoke, O.J. Applicationand characterization of gum from Bombax buonopozense calyxes as an excipient in tablet formulation. Pharmaceutics 2012, 4, 354-365.
7. Hoppel, M.; Mahrhauser, D.; Stallinger, C.; Wagner, F.; Wirth, M.; Valenta, C. Naturalpolymer-stabilized multiple water-in-oil-in-water emulsions: A novel dermal drug delivery system for 5-fluorouracil. J. Pharm. Pharmacol. 2014, doi:10.1111/jphp.12194.
8. Nayak, A.K.; Pal, D.; Pany, D.R.; Mohanty, B. Evaluationof Spinacia oleracea L. leaves mucilage as an innovative suspending agent. J. Adv. Pharm. Technol. Res. 2010, 1, 338-341.
9. Coviello, T.; Dentini, M.; Rambone, G.; Desideri, P.; Carafa, M.; Murtas, E.; Riccieri, F.M.; Alhaique, F. A novel co-crosslinked polysaccharide: Studies for a controlled delivery matrix. J. Control. Release 1998, 55, 57-66.
10. Umekar, M.; Yeole, P. Characterizationand evaluation of natural copal gum-resin as film forming material. Int. J. Green Pharm. 2008, 2, 37-42.
11. Ravikumar; Shirwaikar, A.A.; Shirwaikar, A.; Prabu, S.; Mahalaxmi, R.; Rajendran, K.; Kumar, C. Studiesof Disintegrant Properties of Seed Mucilage of Ocimum gratissimum. Indian J. Pharm. Sci. 2007, 69, 753-758.
12. Avachat, A.M.; Dash, R.R.; Shrotriya, S.N. Recentinvestigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Ind. J. Pharm. Edu. Res. 2011, 45, 86-99.
13. Hoare, T.R.; Kohane, D.S. Hydrogelsin drug delivery: Progress and challenges. Polymer 2008, 49, 1993-2007.
14. Prajapati, V.D.; Jani, G.K.; Moradiya, N.G.; Randeria, N.P. Pharmaceuticalapplications of various natural gums, mucilages and their modified forms. Carbohydr. Polym. 2013, 92, 1685-1699.
15. Wang, S.; Chen, A.; Weng, L.; Chen, M.; Xie, X. Effectof drug-loading methods on drug load, encapsulation efficiency and release properties of alginate/poly-l-arginine/chitosan ternary complex microcapsules. Macromol. Biosci. 2004, 4, 27-30.
16. Ahuja, M.; Kumar, S.; Yadav, M. Evaluationof mimosa seed mucilage as bucoadhesive polymer. Yakugaku Zasshi 2010, 130, 937-944.
17. Vinod, V.T.P.; Sashidhar, R.B.; Suresh, K.I.; Rama Rao, B.; Vijaya Saradhi, U.V.R.; Prabhakar Rao, T. Morphological, Physico-chemical and structural characterization of gum kondagogu (Cochlospermum gossypium): A tree gum from India. Food Hydrocoll. 2008, 22, 899-915.
18. Tha Goh, K.K.; Matia-Merino, L.; Pinder, D.N.; Saavedra, C.; Singh, H. Molecularcharacteristics of a novel water-soluble polysaccharide from the New Zealand black tree fern (Cyathea medullaris). Food Hydrocoll. 2011, 25, 286-292.
19. Saeedi, M.; Morteza-Semnani, K.; Ansoroudi, F.; Fallah, S.; Amin, G. Evaluationof binding properties of Plantago psyllium seed mucilage. Acta Pharm. 2010, 60, 339-348.
20. Rao, M.R.; Sadaphule, P.; Khembete, M.; Lunawat, H.; Thanki, K.; Gabhe, N. Characterizationof psyllium (Plantago ovata) polysaccharide and its use as a binder in tablets. Ind. J. Pharm. Edu. Res. 2013, 47, 154-159.
21. Gowthamarajan, K.; Kumar, G.K.P.; Gaikwad, N.B.; Suresh, B. Preliminarystudy of Anacardium occidentale gum as binder in formulation of paracetamol tablets. Carbohydr. Polym. 2011, 83, 506-511.
22. Deore, S.; Khadabadi, S. Standardisationand pharmaceutical evaluation of Chlorophytum borivilianum mucilage. Rasayan J. Chem. 2008, 1, 887-892.
23. Ghule, B.; Jain, D.; Darwhekar, G.; Yeole, P. Evaluationof binding properties of Eulophia campestris wall mucilage. Indian J. Pharm. Sci. 2006, 68, 566-569.
24. Holy, C.E.; Cheng, C.; Davies, J.E.; Shoichet, M.S. Optimizingthe sterilization of PLGA scaffolds for use in tissue engineering. Biomaterials 2000, 22, 25-31.
25. Singh, B.; Chauhan, N. Modificationof psyllium polysaccharides for use in oral insulin delivery. Food Hydrocoll. 2009, 23, 928-935.
26. Singh, B.; Chauhan, G.S.; Sharma, D.K.; Kant, A.; Gupta, I.; Chauhan, N. Therelease dynamics of model drugs from the psyllium and N-hydroxymethylacrylamide based hydrogels. Int. J. Pharm. 2006, 325, 15-25.
27. Singh, B.; Kumar, S. Synthesisand characterization of psyllium-NVP based drug delivery system through radiation crosslinking polymerization. Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. Atoms 2008, 266, 3417-3430.
28. Singh, B.; Sharma, N. Modificationof sterculia gum with methacrylic acid to prepare a novel drug delivery system. Int. J. Biol. Macromol. 2008, 43, 142-150.
29. Singh, B.; Sharma, N. Developmentof novel hydrogels by functionalization of sterculia gum for use in anti-ulcer drug delivery. Carbohydr. Polym. 2008, 74, 489-497.
30. Bharaniraja, B.; Jayaram Kumar, K.; Prasad, C.M.; Sen, A.K. Differentapproaches of katira gum formulations for colon targeting. Int. J. Biol. Macromol. 2011, 49, 305-310.
31. Bharaniraja, B.; Jayaram Kumar, K.; Prasad, C.M.; Sen, A.K. Modifiedkatira gum for colon targeted drug delivery. J. Appl. Polym. Sci. 2011, 119, 2644-2651.
32. Gliko-Kabir, I.; Yagen, B.; Penhasi, A.; Rubinstein, A. Phosphatedcrosslinked guar for colon-specific drug delivery: I. Preparation and physicochemical characterization. J. Control. Release 2000, 63, 121-127.
33. Silva, D.A.; Feitosa, J.P.A.; Maciel, J.S.; Paula, H.C.B.; de Paula, R.C.M. Characterizationof crosslinked cashew gum derivatives. Carbohydr. Polym. 2006, 66, 16-26.
34. Verraest, D.L.; Peters, J.A.; Batelaan, J.G.; van Bekkum, H. Carboxymethylationof inulin. Carbohydr. Res. 1995, 271, 101-112.
35. Silva, D.A.; de Paula, R.C.M.; Feitosa, J.P.A.; de Brito, A.C.F.; Maciel, J.S.; Paula, H.C.B. Carboxymethylationof cashew tree exudate polysaccharide. Carbohydr. Polym. 2004, 58, 163-171.
36. Goyal, P.; Kumar, V.; Sharma, P. Carboxymethylationof tamarind kernel powder. Carbohydr. Polym. 2007, 69, 251-255.
37. Dey, P.; Sa, B.; Maiti, S. Carboxymethylethers of locust bean gum-a review. Int. J. Pharm. Pharm. Sci. 2011, 3, 4-7.
38. Sen, G.; Pal, S. A novel polymeric biomaterial based on carboxymethylstarch and its application in controlled drug release. J. Appl. Polym. Sci. 2009, 114, 2798-2805.
39. Ren, J.; Sun, R.; Peng, F. Carboxymethylationof hemicelluloses isolated from sugarcane bagasse. Polym. Degrad. Stab. 2008, 93, 786-793.
40. Kobayashi, S.; Tsujihata, S.; Hibi, N.; Tsukamoto, Y. Preparationand rheological characterization of carboxymethyl konjac glucomannan. Food Hydrocoll. 2002, 16, 289-294.
41. Petzold, K.; Schwikal, K.; Günther, W.; Heinze, T. Carboxymethylxylan-Control of properties by synthesis. Macromol. Symp. 2005, 232, 27-36.
42. Parvathy, K.S.; Susheelamma, N.S.; Tharanathan, R.N.; Gaonkar, A.K. A simple non-aqueous method for carboxymethylation of galactomannans. Carbohydr. Polym. 2005, 62, 137-141.
43. Gupta, S.; Sharma, P.; Soni, P.L. Chemicalmodification of Cassia occidentalis seed gum: Carbamoylethylation. Carbohydr. Polym. 2005, 59, 501-506.
44. Sharma, B.R.; Kumar, V.; Soni, P.L. Carbamoylethylationof Cassia tora gum. Carbohydr. Polym. 2003, 54, 143-147.
45. Sharma, B.R.; Kumar, V.; Soni, P.L. Cyanoethylationof Cassia tora gum. Starch Stärke 2003, 55, 38-42.
46. Goyal, P.; Kumar, V.; Sharma, P. Cyanoethylationof tamarind kernel powder. Starch Stärke 2008, 60, 41-47.
47. Deshmukh, V.; Jadhav, J.; Masirkar, V.; Sakarkar, D. Formulation, optimization and evaluation of controlled release alginate microspheres using synergy gum blends. Res. J. Pharm. Technol. 2009, 2, 324-327.
48. Odeku, O.A.; Okunlola, A.; Lamprecht, A. Microbeaddesign for sustained drug release using four natural gums. Int. J. Biol. Macromol. 2013, 58, 113-120.
49. Ngwuluka, N.C.; Choonara, Y.E.; Modi, G.; du Toit, L.C.; Kumar, P.; Ndesendo, V.M.; Pillay, V. Designof an interpolyelectrolyte gastroretentive matrix for the site-specific zero-order delivery of levodopa in Parkinson's disease. AAPS PharmSciTech 2013, 1-15.
50. Yang, L.; Zhang, L. Chemicalstructural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources. Carbohydr. Polym. 2009, 76, 349-361.
51. Shekunov, B.Y.; York, P. Crystallizationprocesses in pharmaceutical technology and drug delivery design. J. Cryst. Growth 2000, 211, 122-136.
52. Harding, S.E.; Vårum, K.; Stokke, B.T.; Smidsrød, O. Molecularweight determination of polysaccharides. Adv. Carbohydr. Anal. 1991, 1, 63-144.
53. Zhang, M.; Zhang, L.; Cheung, P.C.K.; Dong, J. Fractionationand characterization of a polysaccharide from the sclerotia of pleurotus tuber-regium by preparative size-exclusion chromatography. J. Biochem. Biophys. Methods 2003, 56, 281-289.
54. Summers, M.; O'Leary, M. Highspeed, high resolution analysis of low molecular weight polymers using the advanced polymer chromatography (APC) system. Polym. Anal. Appl. 2013, 9-12. Available online: http://www.waters.com/webassets/cms/library/docs/720004752en.pdf (accessed on 11 March 2014).
55. Champion, J.A.; Katare, Y.K.; Mitragotri, S. Particle Shape: A new design parameter for micro- and nanoscale drug delivery carriers. J. Control. Release 2007, 121, 3-9.
56. Caldorera-Moore, M.; Guimard, N.; Shi, L.; Roy, K. Designernanoparticles: Incorporating size, shape and triggered release into nanoscale drug carriers. Expert Opin. Drug Deliv. 2010, 7, 479-495.
57. Eronen, P.; Österberg, M.; Jääskeläinen, A. Effectof alkaline treatment on cellulose supramolecular structure studied with combined confocal Raman spectroscopy and atomic force microscopy. Cellulose 2009, 16, 167-178.
58. Ngwuluka, N.C.; Pillay, V.; Choonara, Y.E.; Modi, G.; Naidoo, D.; Toit, L.C.d.; Kumar, P.; Ndesendo, V.M.K.; Khan, R.A. Fabrication, modeling and characterization of multi-crosslinked methacrylate copolymeric nanoparticles for oral drug delivery. Int. J. Mol. Sci. 2011, 12, 6194-6225.
59. Omelczuk, M.O.; McGinity, J.W. Theinfluence of polymer glass transition temperature and molecular weight on drug release from tablets containing poly (DL-lactic acid). Pharm. Res. 1992, 9, 26-32.
60. Dong, Y.; Ruan, Y.; Wang, H.; Zhao, Y.; Bi, D. Studieson glass transition temperature of chitosan with four techniques. J. Appl. Polym. Sci. 2004, 93, 1553-1558.
61. Jones, D.S.; Woolfson, A.D.; Brown, A.F. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int. J. Pharm. 1997, 151, 223-233.
62. Alur, H.H.; Pather, S.I.; Mitra, A.K.; Johnston, T.P. Transmucosalsustained-delivery of chlorpheniramine maleate in rabbits using a novel, natural mucoadhesive gum as an excipient in buccal tablets. Int. J. Pharm. 1999, 188, 1-10.
63. Kumar, S.V.; Sasmal, D.; Pal, S.C. Rheologicalcharacterization and drug release studies of gum exudates of Terminalia Catappa Linn. AAPS PharmSciTech 2008, 9, 885-890.
64. Kalu, V.; Odeniyi, M.; Jaiyeoba, K. Matrixproperties of a new plant gum in controlled drug delivery. Arch. Pharm. Res. 2007, 30, 884-889.
65. Alur, H.H.; Beal, J.D.; Pather, S.I.; Mitra, A.K.; Johnston, T.P. Evaluationof a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets. J. Pharm. Sci. 1999, 88, 1313-1319.
66. Alur, H.; Pather, S.; Mitra, A.; Johnston, T. Evaluationof the gum from Hakea gibbosa as a sustained-release and mucoadhesive component in buccal tablets. Pharm. Dev. Technol. 1999, 4, 347-358.
67. Alvarez-Lorenzo, C.; Blanco-Fernandez, B.; Puga, A.M.; Concheiro, A. Crosslinkedionic polysaccharides for stimuli-sensitive drug delivery. Adv. Drug Deliv. Rev. 2013, 65, 1148-1171.
68. Singh, B.; Sharma, N.; Chauhan, N. Synthesis, characterization and swelling studies of ph responsive psyllium and methacrylamide based hydrogels for the use in colon specific drug delivery. Carbohydr. Polym. 2007, 69, 631-643.
69. Singh, B.; Chauhan, G.S.; Kumar, S.; Chauhan, N. Synthesis, characterization and swelling responses of pH sensitive psyllium and polyacrylamide based hydrogels for the use in drug delivery (I). Carbohydr. Polym. 2007, 67, 190-200.
70. Liu, L.; Fishman, M.L.; Kost, J.; Hicks, K.B. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003, 24, 3333-3343.
71. Attama, A.A.; Nwabunze, O.J. Mucunagum microspheres for oral delivery of glibenclamide: In vitro evaluation. Acta Pharm. 2007, 57, 161-171.
72. Chu, L.Y.; Choi, S.; Prausnitz, M.R. Fabricationof dissolving polymer microneedles for controlled drug encapsulation and delivery: Bubble and pedestal microneedle designs. J. Pharm. Sci. 2010, 99, 4228-4238.
73. Lee, J.W.; Park, J.; Prausnitz, M.R. Dissolvingmicroneedles for transdermal drug delivery. Biomaterials 2008, 29, 2113-2124.
74. Wang, Z.; Niu, G.; Chen, X. Polymericmaterials for theranostic applications. Pharm. Res. 2013, 1-19.
75. Choi, K.Y.; Chung, H.; Min, K.H.; Yoon, H.Y.; Kim, K.; Park, J.H.; Kwon, I.C.; Jeong, S.Y. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 2010, 31, 106-114.
76. Park, S.Y.; Baik, H.J.; Oh, Y.T.; Oh, K.T.; Youn, Y.S.; Lee, E.S. A smart polysaccharide/drug conjugate for photodynamic therapy. Angew. Chem. Int. Ed. 2011, 50, 1644-1647.
77. Kim, H.S.; Kacew, S.; Lee, B.M. Invitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis 1999, 20, 1637-1640.
78. Singh, K.; Kumar, A.; Langyan, N.; Ahuja, M. Evaluationof Mimosa pudica seed mucilage as sustained-release excipient. AAPS PharmSciTech 2009, 10, 1121-1127.
79. Ahuja, M.; Kumar, A.; Yadav, P.; Singh, K. Mimosapudica seed mucilage: Isolation; characterization and evaluation as tablet disintegrant and binder. Int. J. Biol. Macromol. 2013, 57, 105-110.