Pectin-based systems for colon-specific drug delivery via oral route

Biomaterials

Volumn 24, Issue 19, 2003, Pages 3333-3343

  Liu, LinShu ^a   Fishman, Marshall L ^a   Kost, Joseph ^b   Hicks, Kevin B ^a  

^a EASTERN REGIONAL RESEARCH CENTER   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Colon specific drug delivery; Controlled release; Oral administration; Pectin

Indexed keywords

BIOMATERIALS; CROSSLINKING; DRUG DOSAGE; GELATION;

COLONS; PECTINS;

CONTROLLED DRUG DELIVERY;

CALCIUM DERIVATIVE; DRUG VEHICLE; ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; PECTIN; POLYCATION; POLYELECTROLYTE;

COLON; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; GASTROINTESTINAL TRACT FUNCTION; GELATION; HUMAN; KINETICS; PRIORITY JOURNAL; REVIEW;

EID: 0038055833     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(03)00213-8     Document Type: Review

References (82)

1. Florence A.T., Jani P.U. Particulate delivery. the challenge of the oral route Rolland A. Pharmaceutical particulate carriers: therapeutic applications. 1993;65-107 Marcel Dekker, New York.
2. Chen H., Langer R. Oral particulate delivery. status and future trends Adv Drug Delivery Rev. 34:1998;339-350.
3. Newsletter. Oral drug delivery. DrugDel.com. October 2002.
4. Sinha V.R., Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm. 224:2001;19-38.
5. Vandamme T.F., Lenourry A., Charrueau C., Chaumeil J.C. The use of polysaccharides to target drugs to the colon. Carbohydr Polym. 48:2002;219-231.
6. Fix J.A. Oral controlled release technology for peptides. status and future prospects Pharm Res. 13(12):1996;1760-1763.
7. Rinaudo M. Physicochemical properties of pectins in solution and gel states. Visser J., Voragen A.G.J. Pectin and pectinases. 1996;21-35 Elsevier Science, New York.
8. Marieb EN, Mallatt J. Human anatomy. Menlo Park: Benjamin and Cummings, 1997. p. 561-99.
9. Scheline R.R. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol Rev. 25(4):1973;453-457.
10. MacNeil ME, Stevens HNE. Dispensing device. US Patent No. 5,342,624, 1994.
11. Theeuwes F, Guittard GV, Wong PSL. Delivery of drug to colon by oral disage form. US Patent No. 4,904,474, 1990.
12. Kost J., Langer R. Responsive polymeric delivery systems. Adv Drug Delivery Rev. 46:2001;125-148.
13. Yalpani M. Polysaccharides: synthesis, modifications and structure/property relations. New York: Elsevier Science Publishers, 1988. p. 34-5.
14. BeMiller JM. An introduction to pectins: structure and properties. In: Fishman ML, Jen JJ, editors. Chemistry and function of pectins. Washington, DC: American Chemical Society, 1986. ACS Series 310, p. 2-13.
15. Vauquelin M. Analyse du Tamarin. Ann Chim (Paris). 5:1790;92.
16. Christensen S.H. Pectin. Glickman M. Food hydrocolloids. Vol. III:1984;205-232 CRC Press, Boca Raton, FL.
17. Ashford M., Fell J., Attwood D., Sharma H., Woodhead P. An evaluation of pectin as a carrier for drug targeting to the colon. J Control Rel. 26:1993;213-220.
18. Paoletti S, Cesaro A, Delben F, Ciana A. Ionic effects on the conformation, equilibrium, properties, and rheology of pectate in aqueous solutions and gels. In: Fishman ML, Jen JJ, editors. Chemistry and function of pectins. Washington, DC: American Chemical Society, 1986. ACS Series 310, p. 73-87.
19. Munjeri O., Collett J.H., Fell J.T. Amidated pectin hydrogel beads for colonic drug delivery-an in vitro study. Drug Delivery. 4(3):1997;207-211.
20. Munjeri O., Collett J.H., Fell J.T. Hydrogel beads based on amidated pectins for colon-specific drug delivery. the role of chitosan in modifying drug release J Control Rel. 46:1997;273-278.
21. Wakerly Z., Fell J., Attwood D., Parkins D. Studies on amidated pectins as potential carriers in colonic drug delivery. J Pharm Pharmacol. 49:1997;622-625.
22. Rombouts FM, Thibault JF, Mercier C. Oxidative enzyme-catalyzed cross-linking of beet pectins. US Patent No. 4,672,034, 1987.
23. Rombouts FM, Thibault JF. Sugar beet pectins: chemical structure and gelation through oxidative coupling. In: Fishman ML, Jen JJ, editors. Chemistry and function of pectins. Washington, DC: American Chemical Society, ACS Series 310, 1986. p. 49-60.
24. Toft K, Grasdalen H, Smidsrod O. Synergistic gelation of alginates and pectins. In: Fishman ML, Jen JJ, editors. Chemistry and function of pectins. Washington DC: American Chemical Society, ACS Series 310, 1986. p. 117-33.
25. Thom D., Dea I.C.M., Morris R.E., Powell D.A. Interchain associations of alginate and pectins. Prog Food Nutr Sci. 6:1982;97-108.
26. Kohn R. Ion binding on polyuronates - alginate and pectin. Pure Appl Chem. 42:1975;371-374.
27. Gidley MJ, Morris ER, Murray EJ, Powell DA, Rees DA. Spectroscopic and stoicheiometric characterization of the calcium-mediated association of pectate chains in gels and in solid state. JCS Chem Comm 1979;990-92.
28. Morris E.R., Powell D.A., Gidley M.J., Rees D.A. Conformations and interactions of pectins: I. Polymorphism between gel and solid states of calcium polygalacturonate. J Mol Biol. 155:1982;507-516.
29. Powell D.A., Morris E.R., Gidley M.J., Rees D.A. Conformations and interactions of pectins: II. Influence of residue sequence on chain association in calcium pectate gels. J Mol Biol. 155:1982;517-531.
30. Miller L., MacMilan J.D. Mode of action of pectic enzymes. 2. Further purification of exopolygalacturonate lyase and pectinesterases from clostridium multifermerans. J Bacteriol. 102:1970;72-78.
31. Sandberg A.S., Anderinne R., Anderson G.H., Hallgren B., Hulten L. The effect of citrus pectin on the absorption of nutrients in the small intestine. Hum Nutr Clin Nutr. 37:1983;C171-C173.
32. Ashford M., Fell J., Attwood D., Sharma H., Woodhead P. Studies on pectin formulations for colonic drug delivery. J Control Release. 30:1994;225-232.
33. Rubinstein A. Microbially controlled drug delivery to the colon. Biopharm Drug Disposition. 11(6):1990;465-475.
34. Rubinstein A., Pathak S., Friedman M., Rokem J.S. In vitro method for drug release analysis for microbially controlled delivery systems. Proc Int Symp Control Release Bioact Mater. 17:1990;466-467.
35. Rubinstein A., Radai R. Pectic salt as a colonic drug delivery system. Proc Int Symp Control Release Bioact Mater. 18:1991;221-222.
36. Rubinstein A., Radai R., Ezra M., Pathak S., Rokem S. In vitro evaluation of calcium pectinate. a potential colon-specific drug delivery carrier Pharm Res. 10(2):1993;258-263.
37. Rubinstein A., Radai R. In vitro and in vivo Analysis of colon specificity of calcium pectinate formulations. Eur J Pharm Biopharm. 41(5):1995;291-295.
38. Sintov A, Rubinstein A. Colonic drug delivery system. W/O Patent No. 91/16,881, 1991.
39. Adkin D.A., Kenyon C.J., Lerner E.I., Landau I., Strauss E., Caron D., Penhasi A., Rubinstein A., Wilding I.R. The use of scintigraphy to provide "proof of concept" for novel polysaccharide preparation designed for colonic drug delivery. Pharm Res. 14(1):1997;103-107.
40. Sriamornsak P., Prakongpan S., Puttipipatkhachorn S., Kennedy R.A. Development of sustained release theophylline pellets coated with calcium pectinate. J Control Release. 47:1997;221-231.
41. Sriamornsak P., Nunthanid J. Calcium pectinate gel beads for controlled release drug delivery. II. Effect of formulation and processing variables on drug release J Microencapsulation. 16:1999;303-313.
42. Wong T.W., Lee H.Y., Chan L.W., Heng P.W.S. Drug release properties of pectinate microsphetres prepared by emulsification method. Int J Pharm. 242:2002;233-237.
43. Morris E.R., Richardson R.K., Taylor L.J. Correlation of the perceived texture of random coil polysaccharide solutions with objective parameters. Carbohydr Polym. 4:1984;175-191.
44. May C.D. Industrial pectins. sources, production and applications Carbohydr Polym. 12:1984;79-99.
45. Edman P, Kristensen A, Wideholt B. Therapeutical composition and process for its preparation. W/O Patent No. 92/00,732, 1992.
46. Racope E., Thibault J.F., Rietsma J.C.E., Pilnik W. Properties of amidated pectins. II. Polyelectrolyte behavior and calcium binding of amidated pectin acids. Biopolymers. 28:1989;1435-1448.
47. Wakerly Z., Fell J., Attwood D., Parkins D. Pectin/ethylcellulose film coating formulations for colonic drug delivery. Pharm Res. 13(8):1996;1210-1212.
48. Macleod G.S., Fell J.T., Collett J.H. Studies on the physical properties of mixed pectin/ethylcellulose films intended for colonic drug delivery. Int J Pharm. 157:1997;53-60.
49. Vervoort L., Kinget R. In vitro degradation by colonic bacteria of insulin HP incorporated in eudragit RS films. Int J Pharm. 129(1-2):1996;185-190.
50. Villar-Lopez ME, Otero-Espinar FJ, Blanco-Mendez J. Preliminary studies on mixtures of surelease: pectin as coating formulation of pellets. Proceedings of the 3rd world meeting APV/APGI, 2000;861-62.
51. Bodmeier R., Paeratakul O. Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms. Pharm Res. 11:1994;882-888.
52. Hutchings D., Clarson S., Sakr A. Studies of the mechanical properties of free films prepared using an ethylcellulose pseudolatex coating system. Int J Pharm. 104(3):1994;203-213.
53. Obara S., McGinity J.W. Properties of free films prepared from aqueous polymers by spraying technique. Pharm Res. 11:1994;1562-1567.
54. Obara S., McGinity J.W. Influence of process variables on the properties of free films prepared from aqueous polymeric dispersions by a spray technique. Int J Pharm. 126:1995;1-10.
55. Lippold B.C., Lippold B.H., Sutter B.K., Gunder W. Properties of aqueous plasticizer-containing ethylcellulose dispersion and prepared films in respect to the production of oral extended release formulations. Drug Devel Ind Pharm. 16:1990;1725-1747.
56. Arwidsson H., Hjelstuen O., Ingasen D., Graffner C. Properties of ethylcellulose films for extended release II. Influence of plasticizer content and coalescence conditions when using aqueous dispersion. Acta Pharm Suec. 3:1991;65-70.
57. Perkin K.H., Portery S.C., Rohera B.D. Tensile properties of free cast from aqueous ethylcellulose dispersions. Pharm Res. 10:1993;810-815.
58. Semdé R., Amighi A., Devleeschouwer M.J., Moës A.J. Leaching of pectin from mixed pectin/insoluble polymer films intended for colonic delivery. Int J Pharm. 174:1998;233-241.
59. Semdé R., Amighi A., Devleeschouwer M.J., Moës A.J. Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate. Int J Pharm. 197:2000;169-179.
60. Semdé R., Amighi A., Devleeschouwer M.J., Moës A.J. Studies of pectin HM/Eudragit RL/Eudragit NE film coating formulations intended for colonic drug delivery. Int J Pharm. 197:2000;181-192.
61. Kim J.H., Fassihi R. Application of a binary polymer system in drug release rate modulation. 1. Characterization of release mechanism. J Pharm Sci. 86(3):1997;316-322.
62. Kim J.H., Fassihi R. Application of a binary polymer system in drug release rate modulation. 2. Influences of formulation variables and hydrodynamic conditions on release kinetics. J Pharm Sci. 86(3):1997;323-328.
63. Turkoglu M., Ugurlu T. In vitro evaluation of pectin-HPMC compression coated 5-aminosaclicylic acid tablets for colonic delivery. Eur J Pharm Biopharm. 53:2002;65-73.
64. Kwabena O.K., Fell J.T. Biphasic drug release. the permeability of films containing pectin, chitosan and HPMC Int J Pharm. 226:2001;139-145.
65. Liu L.S., Kost J. Nano- and microspheres from natural polymers. Senior J., Radomsky M. Sustained release injectable products. 2000;203-240 Interpharm Press, Denver.
66. Meshali M.M., Gabr K.E. Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behavior of chloropromazine HCl. Int J Pharm. 89:1993;177-181.
67. Fernandez-Hervas M.J., Fell J.T. Pectin/chitosan mixtures as coatings for colon-specific drug delivery. an in vitro evaluation Int J Pharm. 169:1998;115-119.
68. Macleod G.S., Fell J.T., Collett J.H., Sharma H.L., Smith A-.M. Selective drug delivery to the colon using pectin:chitosan. hydroxypropyl methycellulose film coated tablets Int J Pharm. 187:1999;251-257.
69. Macleod G.S., Fell J.T., Collett J.H. An in vitro investigation into the potential for bimodal drug release from pectin/chitosan/HPMC-coated tablets. Int J Pharm. 188:1999;11-18.
70. Lee V.H., Dodda-Kashi S., Grass G.M., Rubas W. Oral route of peptide and protein drug delivery. Lee V.H. Protein and peptide drug delivery. 1991;691-738 Dekker, New York.
71. Lee V.H., Sporty J., Fandy T.E. Pharmacogenomics of drug transporters. the next drug delivery challenge Adv Drug Delivery Rev. 50:2001;S33-S40.
72. Duchêne D., Ponchel G. Bioadhesion of solid oral dosage forms, why and how? Eur J Pharm Biopharm. 44:1997;15-23.
73. Norris D.A., Puri N., Sinko P. The effect of physical barriers and properties on the oral absorption of particulates. Adv Drug Delivery Rev. 34:1998;135-154.
74. Agoram B., Woltosz W.S., Bolger M.B. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv Drug Delivery Rev. 50:2001;S41-S67.
75. Waterhouse E.T., Washington C., Washington N. An investigation into the efficacy of the pectin based anti-reflux formulation-aflurax. Int J Pharm. 209:2000;79-85.
76. Wagner D., Spahn-Langguth H., Hanafy A., Koggel A., Langguth P. Intestinal drug efflux. formulation and food effects Adv Drug Delivery Rev. 50:2001;S13-S31.
77. Shen H., Howles P., Tso P. From interaction of lipidic vehicles with intestinal epithelia cell membranes to the formation and secretion of chylomicrons. Adv Drug Delivery Rev. 50:2001;S103-S125.
78. Thanou M., Verhoef J.C., Junginger H.E. Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Delivery Rev. 50:2001;S91-S101.
79. O'Driscoll C.M. Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci. 15:2002;405-415.
80. Parrott N., Lavé T. Prediction of intestinal absorption. comparative assessment of GASTROPLUS™ and IDEA™ Eur J Pharm Sci. 17:2002;51-61.
81. Delie F. Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv Drug Delivery Rev. 34:1998;221-233.
82. Dorkoosh F.A., Verhoef J.C., Ambagts M.H.C., Rafiee-Tehrani M., Borchard G., Junginger H.E. Peroral delivery systems based on superporous hydrogel polymers. release characteristics for the peptide drugs buserelin, octreotide and insulin Eur J Pharm Sci. 15:2002;433-439.