Design of an interpolyelectrolyte gastroretentive matrix for the site-specific zero-order delivery of levodopa in Parkinson's disease

AAPS PharmSciTech

Volumn 14, Issue 2, 2013, Pages 605-619

  Ngwuluka, Ndidi C ^a   Choonara, Yahya E ^a   Modi, Girish ^a   Du Toit, Lisa C ^a   Kumar, Pradeep ^a   Ndesendo, Valence M K ^b   Pillay, Viness ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b ST JOHN'S UNIVERSITY OF TANZANIA   (Tanzania)

Author keywords

gastroretention; interpolyelectrolyte complex; levodopa; narrow absorption window drugs; Parkinson's disease

Indexed keywords

LEVODOPA; SOLVENT;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTERPOLYELECTROLYTE COMPLEX; MATHEMATICAL MODEL; MOLECULAR MODEL; PARKINSON DISEASE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ADHESIVENESS; ANIMALS; ANTIPARKINSON AGENTS; CARBOXYMETHYLCELLULOSE SODIUM; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GALACTANS; HARDNESS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LEVODOPA; MANNANS; METHACRYLATES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PARKINSON DISEASE; PLANT GUMS; POLYMERS; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STOMACH; SWINE; TECHNOLOGY, PHARMACEUTICAL;

EID: 84879086992     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-9945-1     Document Type: Article

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