Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 13, 2014, Pages 3279-3284

  Chen, Zhiyong ^a   Cai, Dachuan ^a   Mou, Dehai ^a   Yan, Qin ^b   Sun, Yifeng ^a   Pan, Wenlong ^a   Wan, Yiqian ^b   Song, Huacan ^b   Yi, Wei ^b  

^a Guangzhou) Guangzhou   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

5 Benzylidene(thio)barbiturate; Inhibition mechanism; SARs; Tyrosinase inhibitor

Indexed keywords

5 (2 HYDROXYBENZYLIDEN) 2 THIOXO DIHYROPYRIMIDINE 4,6(1H,5H) DIONE; 5 (2 HYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (2,4 DIHYDROXYBENZYLIDEN) 2 THIOXO DIHYROPYRIMIDINE; 5 (2,4 DIHYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (2,4,6 TRIHYDROXYBENZYLIDEN) 2 THIOXODIHYDROPYRIME 4,6(1H,5H) DIONE; 5 (2,4,6 TRIHYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3 DYDROXYL 4 METHOXYBENZYLIDEN) 2 THIOXODIHYRO PYRIMIDINE 4,6(1H,5H) DIONE; 5 (3 HYDROXYBENZYLIDEN) 2 THIOXO DIHYROPYRIMIDINE; 5 (3 HYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3 HYDROXYL 4 METHOXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3 METHOXYL 4 HYDROXYBENZYLIDEN) 2 THIOXODIHYROPYRIMIDINE 4,6(1H,5H) DIONE; 5 (3 METHOXYL 4 HYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3,4 DIHYDROXYBENZYLIDEN) 2 THIOXO DIHYROPYRIMIDINE; 5 (3,4 DIHYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3,4,5 TRIHYDROXYBENZYLIDEN) 2 THIOXODIHYDROPYRIMIDINE 4,6(1H, 5H) DIONE; 5 (3,4,5 TRIHYDROXYBENZYLIDEN) 2 THIOXODIHYDROPYRIMIDINE 4,6(1H,5H) DIONE; 5 (3,4,5 TRIHYDROXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (3,4,5 TRIMETHOXYBENZYLIDEN) 2 THIOXODIHYROPYRIMIDINE 4,6(1H,5H) DIONE; 5 (3,4,5 TRIMETHOXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 (4 METHOXYBENZYLIDEN) 2 THIOXO DIHYDROPYRIMIDINE 4,6(1H,5H) DIONE; 5 (4 METHOXYBENZYLIDEN)PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; BARBITURIC ACID; BARBITURIC ACID DERIVATIVE; ENZYME INHIBITOR; KOJIC ACID; MONOPHENOL MONOOXYGENASE; PROTOCATECHUALDEHYDE; THIOBARBITURIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; AGARICALES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; METABOLISM; SYNTHESIS;

BASIDIOMYCOTA;

AGARICALES; BARBITURATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR STRUCTURE; MONOPHENOL MONOOXYGENASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901953539     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.060     Document Type: Article

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