Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 10, 2013, Pages 2772-2777

  Gawande, Shrikant S ^a   Warangkar, Suchita C ^b   Bandgar, Babasaheb P ^c   Khobragade, Chandrahasya N ^b  

^a School of Chemical Sciences   (India)

^b SWAMI RAMANAND TEERTH MARATHWADA UNIVERSITY   (India)

^c SOLAPUR UNIVERSITY   (India)

Author keywords

Competitive inhibition; Heterocyclic hybrids; Thiazolidinone scaffolds; Tyrosinase inhibitors

Indexed keywords

1 (1 METHYL BUTA 1,3 DIENYL) 3 PHENYL 1H PYRAZOLE 4 CARBALDEHYDE; 102 (2,4 DIMETHOXY PHENYLAMINO) 5 [3 (2,4 DIMETHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE]THIAZOL 4 ONE; 2 (2,4 DIMETHOXY PHENYLAMINO) 5 METHYLENE 4 THIAZOLINONE; 2 (2,4 DIMETHOXY PHENYLAMINO) 5 METHYLENE THIAZOL 4 ONE; 2 (2,4 DIMETHOXY PHENYLAMINO) THIAZOL 4 ONE; 22 (2,4 DIMETHOXY PHENYLAMINO) 5 (1 PHENYL 3 PARA TOLYL 1H PYRAZOL 4 YLMET HYLE NE)THIAZOL 4 ONE; 32 (2,4 DIMETHOXY PHENYLAMINO) 5 [3 (4 METHOXY PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE]THIAZOL 4 ONE; 4 THIAZOLIDINONE DERIVATIVE; 45 [3 (4 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYL ENE] 2 (2,4 DIMETHOXY PHENYLAMINO)THIAZOL 4 ONE; 5 [3 (2 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE] 2 (2, 4 DIMETHOXY PHENYLAMINO) THIAZOL 4 ONE; 5 [3 (3 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE] 2 (2,4 DIMETHOXY PHENYLAMINO) THIAZOL 4 ONE; 55 [3 (4 BROMO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYL ENE] 2 (2,4 DIMETHOXY PHENYLAMINO)THIAZOL 4 ONE; 62 (2,4 DIMETHOXY PHENYLAMINO) 5 [3 (4 FLUORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE]THIAZOL 4 ONE; 75 [3 (3 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE] 2 (2,4 DIMETHOXY PHENYLAMINO)THIAZOL 4 ONE; 85 [3 (2 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE] 2 (2,4 DIMETHOXY PHENYLAMINO)THIAZOL 4 ONE; 95 [3 (2,4 CHLORO PHENYL) 1 PHENYL 1H PYRAZOL 4 YLMETHYLENE] 2 (2,4 DIMETHOXY PHENYLAMINO)THIAZOL 4 ONE; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; KOJIC ACID; MONOPHENOL MONOOXYGENASE; PYRAZOLE DERIVATIVE; TYROSINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; ENZYME INHIBITORS; HUMANS; MONOPHENOL MONOOXYGENASE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84876688543     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.053     Document Type: Article

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