Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 2156-2162

  Zhou, Zhixuan ^a   Zhuo, Jiaru ^a   Yan, Sujun ^a   Ma, Lin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

4,5 Dihydro 1H pyrazole; Inhibit; Mushroom tyrosinase

Indexed keywords

1 [3 (2 HYDROXYPHENYL) 5 (3 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2 HYDROXYPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2,4 DIHYDROXYPHENYL) 5 (3 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2,4 DIHYDROXYPHENYL) 5 (3,4 DIHYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2,4 DIHYDROXYPHENYL) 5 (4 HYDROXY 3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2,4 DIHYDROXYPHENYL) 5 (4 HYDROXY 3 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (2,4 DIHYDROXYPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (3,5 DIHYDROXYPHENYL) 5 (3 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3 (3,5 DIHYDROXYPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [3,5 BIS(4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [5 (3 HYDROXYPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [5 (3,4 D IHYDROXYPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [5 (4 HYDROXY 2 METHOXYPHENYL) 3 (2 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [5 (4 HYDROXY 3 METHOXYPHENYL) 3 (2 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [5 (4 HYDROXY 3 METHOXYPHENYL) 3 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 2 [5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3-YL]PHENOL; 3,5 DIARYL 4,5 DIHYDRO 1H PYRAZOLE DERIVATIVE; 4 [5 (3 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]BENZENE 1,3 DIOL; 4 [5 (4 HYDROXY 3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]BENZENE 1,3 DIOL; 4 [5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]BENZENE 1,3 DIOL; ENZYME INHIBITOR; KOJIC ACID; MONOPHENOL MONOOXYGENASE; TYROSINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MUSHROOM; NONHUMAN; PHARMACOKINETICS; STRUCTURE ACTIVITY RELATION;

AGARICALES; ENZYME INHIBITORS; KINETICS; MONOPHENOL MONOOXYGENASE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

BASIDIOMYCOTA;

EID: 84875229179     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.054     Document Type: Article

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