-
1
-
-
33746465014
-
Preventing cardiovascular disease and diabetes: A call to action from the American Diabetes Association and the American Heart Association
-
Eckel RH, Kahn R, Robertson RM, Rizza RA. Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. Diabetes Care 2006;29:1697-1699
-
(2006)
Diabetes Care
, vol.29
, pp. 1697-1699
-
-
Eckel, R.H.1
Kahn, R.2
Robertson, R.M.3
Rizza, R.A.4
-
2
-
-
33644850953
-
Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
-
Poirier P, Giles TD, Bray GA, et al.; American Heart Association; Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113:898-918
-
(2006)
Circulation
, vol.113
, pp. 898-918
-
-
Poirier, P.1
Giles, T.D.2
Bray, G.A.3
-
3
-
-
31544480404
-
Cardiovascular mortality in overweight subjects: The key role of associated risk factors
-
Thomas F, Bean K, Pannier B, Oppert JM, Guize L, Benetos A. Cardiovascular mortality in overweight subjects: the key role of associated risk factors. Hypertension 2005;46:654-659
-
(2005)
Hypertension
, vol.46
, pp. 654-659
-
-
Thomas, F.1
Bean, K.2
Pannier, B.3
Oppert, J.M.4
Guize, L.5
Benetos, A.6
-
4
-
-
0025773972
-
The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study
-
Lauer MS, Anderson KM, Kannel WB, Levy D. The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. JAMA 1991; 266:231-236
-
(1991)
JAMA
, vol.266
, pp. 231-236
-
-
Lauer, M.S.1
Anderson, K.M.2
Kannel, W.B.3
Levy, D.4
-
5
-
-
0027305107
-
Obesity and the heart
-
Alexander JK. Obesity and the heart. Heart Dis Stroke 1993;2:317-321
-
(1993)
Heart Dis Stroke
, vol.2
, pp. 317-321
-
-
Alexander, J.K.1
-
6
-
-
0036617626
-
Echocardiographic abnormalities in normotensive obese patients: Relationship with visceral fat
-
Morricone L, Malavazos AE, Coman C, Donati C, Hassan T, Caviezel F. Echocardiographic abnormalities in normotensive obese patients: relationship with visceral fat. Obes Res 2002;10:489-498
-
(2002)
Obes Res
, vol.10
, pp. 489-498
-
-
Morricone, L.1
Malavazos, A.E.2
Coman, C.3
Donati, C.4
Hassan, T.5
Caviezel, F.6
-
7
-
-
36048991085
-
Physiology. An integrative view of obesity
-
Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science 2007;318:928-929
-
(2007)
Science
, vol.318
, pp. 928-929
-
-
Wisse, B.E.1
Kim, F.2
Schwartz, M.W.3
-
8
-
-
0036326045
-
Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart
-
Young ME, Guthrie PH, Razeghi P, et al. Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes 2002;51:2587-2595
-
(2002)
Diabetes
, vol.51
, pp. 2587-2595
-
-
Young, M.E.1
Guthrie, P.H.2
Razeghi, P.3
-
9
-
-
31544477999
-
Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice
-
Dong F, Zhang X, Yang X, et al. Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. J Endocrinol 2006;188:25-36
-
(2006)
J Endocrinol
, vol.188
, pp. 25-36
-
-
Dong, F.1
Zhang, X.2
Yang, X.3
-
11
-
-
78449271832
-
Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart
-
Ballal K, Wilson CR, Harmancey R, Taegtmeyer H. Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart. Mol Cell Biochem 2010;344:221-230
-
(2010)
Mol Cell Biochem
, vol.344
, pp. 221-230
-
-
Ballal, K.1
Wilson, C.R.2
Harmancey, R.3
Taegtmeyer, H.4
-
12
-
-
77957855881
-
Specialized roles for cysteine cathepsins in health and disease
-
Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 2010;120:3421-3431
-
(2010)
J Clin Invest
, vol.120
, pp. 3421-3431
-
-
Reiser, J.1
Adair, B.2
Reinheckel, T.3
-
13
-
-
79960150092
-
Cysteinyl cathepsins and mast cell proteases in the patho-genesis and therapeutics of cardiovascular diseases
-
Qin Y, Shi GP. Cysteinyl cathepsins and mast cell proteases in the patho-genesis and therapeutics of cardiovascular diseases. Pharmacol Ther 2011; 131:338-350
-
(2011)
Pharmacol Ther
, vol.131
, pp. 338-350
-
-
Qin, Y.1
Shi, G.P.2
-
14
-
-
84859061110
-
Role for cysteine protease cathepsins in heart disease: Focus on biology and mechanisms with clinical implication
-
Cheng XW, Shi GP, Kuzuya M, Sasaki T, Okumura K, Murohara T. Role for cysteine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication. Circulation 2012;125:1551-1562
-
(2012)
Circulation
, vol.125
, pp. 1551-1562
-
-
Cheng, X.W.1
Shi, G.P.2
Kuzuya, M.3
Sasaki, T.4
Okumura, K.5
Murohara, T.6
-
15
-
-
24644518893
-
Cathepsin S, a novel biomarker of adiposity: Relevance to atherogenesis
-
Taleb S, Lacasa D, Bastard JP, et al. Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis. FASEB J 2005;19:1540-1542
-
(2005)
FASEB J
, vol.19
, pp. 1540-1542
-
-
Taleb, S.1
Lacasa, D.2
Bastard, J.P.3
-
16
-
-
33646518541
-
Increased serum cathepsin S in patients with atherosclerosis and diabetes
-
Liu J, Ma L, Yang J, et al. Increased serum cathepsin S in patients with atherosclerosis and diabetes. Atherosclerosis 2006;186:411-419
-
(2006)
Atherosclerosis
, vol.186
, pp. 411-419
-
-
Liu, J.1
Ma, L.2
Yang, J.3
-
18
-
-
0032145836
-
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
-
Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998;102:576-583
-
(1998)
J Clin Invest
, vol.102
, pp. 576-583
-
-
Sukhova, G.K.1
Shi, G.P.2
Simon, D.I.3
Chapman, H.A.4
Libby, P.5
-
19
-
-
1542469612
-
Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries
-
Cheng XW, Kuzuya M, Sasaki T, et al. Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Am J Pathol 2004;164:243-251
-
(2004)
Am J Pathol
, vol.164
, pp. 243-251
-
-
Cheng, X.W.1
Kuzuya, M.2
Sasaki, T.3
-
20
-
-
33746834187
-
Increased expression of elas-tolytic cathepsins S, K, and v and their inhibitor cystatin C in stenotic aortic valves
-
Helske S, Syväranta S, Lindstedt KA, et al. Increased expression of elas-tolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves. Arterioscler Thromb Vasc Biol 2006;26:1791-1798
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1791-1798
-
-
Helske, S.1
Syväranta, S.2
Lindstedt, K.A.3
-
21
-
-
33750246799
-
Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure
-
Cheng XW, Obata K, Kuzuya M, et al. Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure. Hypertension 2006;48:979-987
-
(2006)
Hypertension
, vol.48
, pp. 979-987
-
-
Cheng, X.W.1
Obata, K.2
Kuzuya, M.3
-
22
-
-
33646364542
-
Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy
-
Ge J, Zhao G, Chen R, et al. Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy. Eur J Heart Fail 2006;8:284-289
-
(2006)
Eur J Heart Fail
, vol.8
, pp. 284-289
-
-
Ge, J.1
Zhao, G.2
Chen, R.3
-
23
-
-
60549104999
-
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling
-
Tang Q, Cai J, Shen D, et al. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. J Mol Med (Berl) 2009;87:249-260
-
(2009)
J Mol Med (Berl)
, vol.87
, pp. 249-260
-
-
Tang, Q.1
Cai, J.2
Shen, D.3
-
24
-
-
57549118164
-
Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice
-
Yang M, Sun J, Zhang T, et al. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arte-rioscler Thromb Vasc Biol 2008;28:2202-2208
-
(2008)
Arte-rioscler Thromb Vasc Biol
, vol.28
, pp. 2202-2208
-
-
Yang, M.1
Sun, J.2
Zhang, T.3
-
25
-
-
33646870167
-
Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass
-
Li CY, Jepsen KJ, Majeska RJ, et al. Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res 2006;21:865-875
-
(2006)
J Bone Miner Res
, vol.21
, pp. 865-875
-
-
Li, C.Y.1
Jepsen, K.J.2
Majeska, R.J.3
-
26
-
-
78650826465
-
Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction
-
Ceylan-Isik AF, Sreejayan N, Ren J. Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction. J Mol Cell Cardiol 2011;50:107-116
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 107-116
-
-
Ceylan-Isik, A.F.1
Sreejayan, N.2
Ren, J.3
-
27
-
-
64249100372
-
Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction
-
Doser TA, Turdi S, Thomas DP, Epstein PN, Li SY, Ren J. Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation 2009;119:1941-1949
-
(2009)
Circulation
, vol.119
, pp. 1941-1949
-
-
Doser, T.A.1
Turdi, S.2
Thomas, D.P.3
Epstein, P.N.4
Li, S.Y.5
Ren, J.6
-
28
-
-
0038532298
-
A role for ceramide, but not diac-ylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
-
Chavez JA, Knotts TA, Wang LP, et al. A role for ceramide, but not diac-ylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 2003;278:10297-10303
-
(2003)
J Biol Chem
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
Knotts, T.A.2
Wang, L.P.3
-
29
-
-
34548434021
-
Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: Role of peroxisome pro-liferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis
-
Dong F, Li Q, Sreejayan N, Nunn JM, Ren J. Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome pro-liferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes 2007;56:2201-2212
-
(2007)
Diabetes
, vol.56
, pp. 2201-2212
-
-
Dong, F.1
Li, Q.2
Sreejayan, N.3
Nunn, J.M.4
Ren, J.5
-
30
-
-
33845652579
-
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice
-
Petermann I, Mayer C, Stypmann J, et al. Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice. FASEB J 2006;20:1266-1268
-
(2006)
FASEB J
, vol.20
, pp. 1266-1268
-
-
Petermann, I.1
Mayer, C.2
Stypmann, J.3
-
31
-
-
37549072689
-
Cell type-specific functions of the lysosomal protease cathepsin L in the heart
-
Spira D, Stypmann J, Tobin DJ, et al. Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem 2007;282:37045-37052
-
(2007)
J Biol Chem
, vol.282
, pp. 37045-37052
-
-
Spira, D.1
Stypmann, J.2
Tobin, D.J.3
-
32
-
-
0034652225
-
Lipotoxic heart disease in obese rats: Implications for human obesity
-
Zhou YT, Grayburn P, Karim A, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci USA 2000;97:1784-1789
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1784-1789
-
-
Zhou, Y.T.1
Grayburn, P.2
Karim, A.3
-
33
-
-
0037264995
-
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy
-
Nakayama H, Otsu K, Yamaguchi O, et al. Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy. FASEB J 2003;17:61-63
-
(2003)
FASEB J
, vol.17
, pp. 61-63
-
-
Nakayama, H.1
Otsu, K.2
Yamaguchi, O.3
-
34
-
-
0034616217
-
Cardiac-specific overexpression of a superinhibitory pentameric phos-pholamban mutant enhances inhibition of cardiac function in vivo
-
Zhai J, Schmidt AG, Hoit BD, Kimura Y, MacLennan DH, Kranias EG. Cardiac-specific overexpression of a superinhibitory pentameric phos-pholamban mutant enhances inhibition of cardiac function in vivo. J Biol Chem 2000;275:10538-10544
-
(2000)
J Biol Chem
, vol.275
, pp. 10538-10544
-
-
Zhai, J.1
Schmidt, A.G.2
Hoit, B.D.3
Kimura, Y.4
MacLennan, D.H.5
Kranias, E.G.6
-
35
-
-
33645820598
-
Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload
-
Matsusaka H, Ide T, Matsushima S, et al. Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload. Hypertension 2006;47:711-717
-
(2006)
Hypertension
, vol.47
, pp. 711-717
-
-
Matsusaka, H.1
Ide, T.2
Matsushima, S.3
-
37
-
-
0037020157
-
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status
-
Shiojima I, Yefremashvili M, Luo Z, et al. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002;277:37670-37677
-
(2002)
J Biol Chem
, vol.277
, pp. 37670-37677
-
-
Shiojima, I.1
Yefremashvili, M.2
Luo, Z.3
-
38
-
-
37349085478
-
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
-
Kemi OJ, Ceci M, Wisloff U, et al. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol 2008;214:316-321
-
(2008)
J Cell Physiol
, vol.214
, pp. 316-321
-
-
Kemi, O.J.1
Ceci, M.2
Wisloff, U.3
-
39
-
-
33748132517
-
Apoptosis in hypertensive heart disease: A clinical approach
-
González A, Ravassa S, López B, Loperena I, Querejeta R, Díez J. Apoptosis in hypertensive heart disease: a clinical approach. Curr Opin Cardiol 2006; 21:288-294
-
(2006)
Curr Opin Cardiol
, vol.21
, pp. 288-294
-
-
González, A.1
Ravassa, S.2
López, B.3
Loperena, I.4
Querejeta, R.5
Díez, J.6
-
40
-
-
0037405694
-
Clinical implications of apoptosis in hypertensive heart disease
-
Fortuño MA, González A, Ravassa S, López B, Díez J. Clinical implications of apoptosis in hypertensive heart disease. Am J Physiol Heart Circ Physiol 2003;284:H1495-H1506
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.284
-
-
Fortuño, M.A.1
González, A.2
Ravassa, S.3
López, B.4
Díez, J.5
-
41
-
-
0034739734
-
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
-
Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 2000; 62:273-295
-
(2000)
Prog Neurobiol
, vol.62
, pp. 273-295
-
-
Yamashima, T.1
|