Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF

Laboratory Investigation

Volumn 91, Issue 5, 2011, Pages 691-703

  Kikuchi, Ryosuke ^a   Takeshita, Kyosuke ^a,b   Uchida, Yasuhiro ^a   Kondo, Megumi ^a   Cheng, Xian Wu ^a   Nakayama, Takayuki ^a   Yamamoto, Koji ^b   Matsushita, Tadashi ^b   Liao, James K ^c   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Akt; angio arteriogenesis; endothelial function; Notch signal pathway; statins

Indexed keywords

EPHRIN B2; GAMMA SECRETASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIGEL; NOTCH1 RECEPTOR; PITAVASTATIN; PROTEIN KINASE B; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTICLE; BLOOD FLOW; CAPILLARY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; HINDLIMB; HUMAN; HUMAN CELL; LIMB ISCHEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

ANIMALS; ARTERIES; BLOOD CIRCULATION; BLOTTING, WESTERN; CELL LINE; DISEASE MODELS, ANIMAL; HINDLIMB; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; QUINOLINES; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955528596     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.5     Document Type: Article

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