Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages 8167-8172

  Charles, Rebecca L ^a   Rudyk, Olena ^a   Prysyazhna, Oleksandra ^a   Kamynina, Alisa ^a   Yang, Jun ^b,c   Morisseau, Christophe ^b,c   Hammock, Bruce D ^b,c   Freeman, Bruce A ^d   Eaton, Philip ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular; Thiol

Indexed keywords

10 NITRO OLEIC ACID; 11 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; FATTY ACID; HYDROLASE; HYDROXYICOSATETRAENOIC ACID; NITRO FATTY ACID; SOLUBLE EPOXIDE HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; ELECTROPHILICITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENOTYPE; HYPERTENSION; MEAN ARTERIAL PRESSURE; MEDITERRANEAN DIET; MESENTERY BLOOD VESSEL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VASODILATATION;

CARDIOVASCULAR; THIOL;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; CELLULASE; DIET, MEDITERRANEAN; DISEASE MODELS, ANIMAL; EPOXIDE HYDROLASES; FATTY ACIDS; GENE KNOCK-IN TECHNIQUES; HYPERTENSION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NITRATES; NITRITES; SULFHYDRYL COMPOUNDS; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 84901850882     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402965111     Document Type: Article

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