Inhibitory receptor immunoglobulin-like transcript 4 was highly expressed in primary ductal and lobular breast cancer and significantly correlated with IL-10

Diagnostic Pathology

Volumn 9, Issue 1, 2014, Pages

  Liu, Jie ^a   Wang, Linlin ^a   Gao, Wei ^a   Li, Liwen ^a   Cui, Xia ^a   Yang, Hongyan ^a   Lin, Wenli ^a   Dang, Qi ^a   Zhang, Nan ^a   Sun, Yuping ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Breast cancer; Immunoglobulin like transcript 4; Immunohistochemistry; Interleukin 10; Tumor infiltrating lymphocytes

Indexed keywords

IL10 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 10; LILRB2 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADULT; AGED; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; LUNG CARCINOMA; LYMPH NODE METASTASIS; MCF 7 CELL LINE; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; SECONDARY; TUMOR ASSOCIATED LEUKOCYTE; YOUNG ADULT;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-10; LYMPHATIC METASTASIS; LYMPHOCYTES, TUMOR-INFILTRATING; MCF-7 CELLS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC; YOUNG ADULT;

EID: 84901839241     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-9-85     Document Type: Article

References (39)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013, 63:11-30. 10.3322/caac.21166, 23335087.
2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013, 21376230.
3. Cavallo F, De Giovanni C, Nanni P, Forni G, Lollini PL. 2011: the immune hallmarks of cancer. Cancer Immunol Immunother 2011, 60:319-326. 10.1007/s00262-010-0968-0, 3042096, 21267721.
4. Denfeld RW, Dietrich A, Wuttig C, Tanczos E, Weiss JM, Vanscheidt W, Schopf E, Simon JC. In situ expression of B7 and CD28 receptor families in human malignant melanoma: relevance for T-cell-mediated anti-tumor immunity. Int J Cancer 1995, 62:259-265. 10.1002/ijc.2910620305, 7543078.
5. Wroblewski JM, Bixby DL, Borowski C, Yannelli JR. Characterization of human non-small cell lung cancer (NSCLC) cell lines for expression of MHC, co-stimulatory molecules and tumor-associated antigens. Lung Cancer 2001, 33:181-194. 10.1016/S0169-5002(01)00210-0, 11551413.
6. Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8:793-800.
7. Leibson PJ. The regulation of lymphocyte activation by inhibitory receptors. Curr Opin Immunol 2004, 16:328-336. 10.1016/j.coi.2004.03.006, 15134782.
8. Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005, 11:2947-2953. 10.1158/1078-0432.CCR-04-1469, 15837746.
9. Sun Y, Wang Y, Zhao J, Gu M, Giscombe R, Lefvert AK, Wang X. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006, 53:143-151. 10.1016/j.lungcan.2006.05.012, 16782226.
10. Colonna M, Nakajima H, Navarro F, Lopez-Botet M. A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J Leukoc Biol 1999, 66:375-381.
11. McQueen KL, Parham P. Variable receptors controlling activation and inhibition of NK cells. Curr Opin Immunol 2002, 14:615-621. 10.1016/S0952-7915(02)00380-1, 12183162.
12. Colonna M, Nakajima H, Cella M. A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin Immunol 2000, 12:121-127. 10.1006/smim.2000.0214, 10764620.
13. Barten R, Torkar M, Haude A, Trowsdale J, Wilson MJ. Divergent and convergent evolution of NK-cell receptors. Trends Immunol 2001, 22:52-57. 10.1016/S1471-4906(00)01802-0, 11286693.
14. Trowsdale J, Barten R, Haude A, Stewart CA, Beck S, Wilson MJ. The genomic context of natural killer receptor extended gene families. Immunol Rev 2001, 181:20-38. 10.1034/j.1600-065X.2001.1810102.x, 11513141.
15. Vilches C, Parham P. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol 2002, 20:217-251. 10.1146/annurev.immunol.20.092501.134942, 11861603.
16. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med 1997, 185:1743-1751. 10.1084/jem.185.10.1743, 2196312, 9151699.
17. Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N. Tolerization of dendritic cells by T (S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002, 3:237-243. 10.1038/ni760, 11875462.
18. Kim-Schulze S, Seki T, Vlad G, Scotto L, Fan J, Colombo PC, Liu J, Cortesini R, Suciu-Foca N. Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells. Am J Transplant 2006, 6:76-82. 10.1111/j.1600-6143.2005.01162.x, 16433759.
19. Manavalan JS, Kim-Schulze S, Scotto L, Naiyer AJ, Vlad G, Colombo PC, Marboe C, Mancini D, Cortesini R, Suciu-Foca N. Alloantigen specific CD8 + CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol 2004, 16:1055-1068. 10.1093/intimm/dxh107, 15226269.
20. Suciu-Foca N, Manavalan JS, Cortesini R. Generation and function of antigen-specific suppressor and regulatory T cells. Transpl Immunol 2003, 11:235-244. 10.1016/S0966-3274(03)00052-2, 12967777.
21. Sun Y, Liu J, Gao P, Wang Y, Liu C. Expression of Ig-like transcript 4 inhibitory receptor in human non-small cell lung cancer. Chest 2008, 134:783-788. 10.1378/chest.07-1100, 18625675.
22. Colovai AI, Tsao L, Wang S, Lin H, Wang C, Seki T, Fisher JG, Menes M, Bhagat G, Alobeid B, Suciu-Foca N. Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia. Cytometry B Clin Cytom 2007, 72:354-362.
23. Manavalan JS, Rossi PC, Vlad G, Piazza F, Yarilina A, Cortesini R, Mancini D, Suciu-Foca N. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 2003, 11:245-258. 10.1016/S0966-3274(03)00058-3, 12967778.
24. Xu X, Zou P, Chen L, Jin G, Zhou H. IL-10 enhances promoter activity of ILT4 gene and up-regulates its expression in THP-1 cells. J Huazhong Univ Sci Technolog Med Sci 2010, 30:594-598. 10.1007/s11596-010-0548-8, 21063840.
25. Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur J Immunol 2007, 37:177-192. 10.1002/eji.200636498, 17163451.
26. Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000, 290:84-89. 10.1126/science.290.5489.84, 11021804.
27. Itakura E, Huang RR, Wen DR, Paul E, Wunsch PH, Cochran AJ. IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence. Mod Pathol 2011, 24:801-809. 10.1038/modpathol.2011.5, 3106125, 21317876.
28. Nodin B, Zendehrokh N, Sundstrom M, Jirstrom K. Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer. Diagn Pathol 2013, 8:106. 10.1186/1746-1596-8-106, 3722044, 23800114.
29. Schilling B, Bielefeld N, Sucker A, Hillen U, Zimmer L, Schadendorf D, Zeschnigk M, Griewank KG. Lack of SF3B1 R625 mutations in cutaneous melanoma. Diagn Pathol 2013, 8:87. 10.1186/1746-1596-8-87, 3671181, 23694694.
30. Cheng H, Qin Y, Fan H, Su P, Zhang X, Zhang H, Zhou G. Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes. Diagn Pathol 2013, 8:129. 10.1186/1746-1596-8-129, 3766166, 23915145.
31. Guo L, Meng J, Yilamu D, Jakulin A, Fu M, Wang B, Abulajiang G. Significance of ERbeta expression in different molecular subtypes of breast cancer. Diagn Pathol 2014, 9:20. 10.1186/1746-1596-9-20, 3911955, 24457087.
32. Liu J, Liu Z, Witkowski P, Vlad G, Manavalan JS, Scotto L, Kim-Schulze S, Cortesini R, Hardy MA, Suciu-Foca N. Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol 2004, 13:239-247. 10.1016/j.trim.2004.10.006, 15589736.
33. Amodio G, Mugione A, Sanchez AM, Vigano P, Candiani M, Somigliana E, Roncarolo MG, Panina-Bordignon P, Gregori S. HLA-G expressing DC-10 and CD4 (+) T cells accumulate in human decidua during pregnancy. Hum Immunol 2013, 74:406-411. 10.1016/j.humimm.2012.11.031, 3610019, 23238214.
34. Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, Toth I, Pereyra F, Lichterfeld M, Yu XG. Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2. J Virol 2010, 84:10784-10791. 10.1128/JVI.01292-10, 2950595, 20702625.
35. Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1991, 174:1549-1555. 10.1084/jem.174.6.1549, 2119047, 1744584.
36. Hashimoto SI, Komuro I, Yamada M, Akagawa KS. IL-10 inhibits granulocyte-macrophage colony-stimulating factor-dependent human monocyte survival at the early stage of the culture and inhibits the generation of macrophages. J Immunol 2001, 167:3619-3625. 10.4049/jimmunol.167.7.3619, 11564774.
37. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993, 11:165-190. 10.1146/annurev.iy.11.040193.001121, 8386517.
38. Llanes-Fernandez L, Alvarez-Goyanes RI, Arango-Prado Mdel C, Alcocer-Gonzalez JM, Mojarrieta JC, Perez XE, Lopez MO, Odio SF, Camacho-Rodriguez R, Guerra-Yi ME, Madrid-Marina V, Tamez-Guerra R, Rodriguez-Padilla C. Relationship between IL-10 and tumor markers in breast cancer patients. Breast 2006, 15:482-489. 10.1016/j.breast.2005.09.012, 16403632.
39. Chavey C, Bibeau F, Gourgou-Bourgade S, Burlinchon S, Boissiere F, Laune D, Roques S, Lazennec G. Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res 2007, 9:R15. 10.1186/bcr1648, 1851386, 17261184.