Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  Chen, Bainian ^a,b,c   Zhao, Qing ^c,d   Ni, Rui ^b,c   Tang, Futian ^b,c   Shan, Limei ^b,c   Cepinskas, Inga ^b   Cepinskas, Gediminas ^b   Wang, Wang ^e   Schiller, Peter W ^f   Peng, Tianqing ^a,b,c,g  

^a SOOCHOW UNIVERSITY   (China)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF WASHINGTON   (United States)

^f CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^g LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Calpain; Diabetes; Endothelial dysfunction; eNOS; ROS

Indexed keywords

CALPAIN; CALPASTATIN; DIMER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; NITRIC OXIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIMERIZATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INTRACELLULAR SPACE; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING;

ANIMALS; CALPAIN; DIABETES MELLITUS; ENDOTHELIUM, VASCULAR; GLYCOPROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84901828562     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-88     Document Type: Article

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