Two distinct calcium-dependent mitochondrial pathways are involved in oxidized LDL-induced apoptosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 25, Issue 3, 2005, Pages 639-645

  Vindis, Cécile ^a   Elbaz, Meyer ^a   Escargueil Blanc, Isabelle ^a   Auge, Nathalie ^a   Heniquez, Aurelia ^a   Thiers, Jean Claude ^a   Nègre Salvayre, Anne ^a   Salvayre, Robert ^a,b  

^a CHU RANGUEIL   (France)

^b INSERM   (France)

Author keywords

Apoptosis inducing factor; Atherosclerosis; Calpain; Caspase; Mitochondria; Oxidized low density lipoprotein

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CALPAIN; CYCLOSPORIN A; CYTOCHROME C; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TACROLIMUS;

APOPTOSIS; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EVALUATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; ARTERIOSCLEROSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CALCIUM; CALPAIN; CARRIER PROTEINS; CASPASE 3; CASPASES; CELLS, CULTURED; CYCLOSPORINE; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; ENDOTHELIUM, VASCULAR; FLAVOPROTEINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIPOPROTEINS, LDL; MEMBRANE PROTEINS; MICROCIRCULATION; MITOCHONDRIA; TACROLIMUS;

EID: 14644395593     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000154359.60886.33     Document Type: Article

References (40)

1. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241.
2. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
3. Dimmeler S, Hermann C, Zeiher AM. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw. 1998;9:697-698.
4. Mallat Z, Tedgui A. Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol. 2000;130:947-962.
5. Geng YJ, Libby P. Progression of atheroma: a struggle between death and procreation. Arterioscler Thromb Vasc Biol. 2002;22:1370-1380.
6. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modification of LDL that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
7. Colles SM, Maxson JM, Carlson SG, Chisolm GM. Oxidized LDL-induced injury and apoptosis in atherosclerosis. Potential roles for oxysterols. Trends Cardiovasc Med. 2001;11:131-138.
8. Salvayre R, Auge N, Benoist H, Negre-Salvayre A. Oxidized LDL-induced apoptosis. Biochim Biophys Acta. 2002;1585:213-221.
9. Napoli C, Oxidation of LDL, atherogenesis, and apoptosis. Ann N Y Acad Sci. 2003;1010:698-709.
10. Li D, Yang B, Mehta JL. Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am J Physiol. 1998;275(pt 2):H568-H576.
11. Sata M, Walsh K. Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest. 1998;102:1682-1689.
12. Chen J, Mehta JL, Haider N, Zhang X, Narula J, Li D. Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res. 2004;94:370-376.
13. Walter DH, Haendeler J, Galle J, Zeiher AM, Dimmeler S. Cyclosporine-A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria. Circulation. 1998;98:1153-1157.
14. Escargueil-Blanc I, Salvayre R, Nègre-Salvayre A. Necrosis and apoptosis induced by oxidized LDL occur through two calcium-dependent pathways in lymphoblastoid cells. FASEB J. 1994;8:1075-1080.
15. Porn-Ares MI, Saido TC, Andersson T, Ares MP. Oxidized LDL induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J. 2003;374:403-411.
16. Dimmeler S, Haendeler J, Galle J, Zeiher AM. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation. 1997;95:1760-1763.
17. Zhang W, Li D, Mehta JL. Role of AIF in human coronary artery endothelial cell apoptosis. Am J Physiol Heart Circ Physiol. 2004;286: H354-H358.
18. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol. 2003;4:552-565.
19. Meilhac O, Escargueil-Blanc I, Thiers JC, Salvayre R, Negre-Salvayre A. Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized LDL. FASEB J. 1999;13: 485-494.
20. Vieira O, Escargueil-Blanc I, Jurgens G, Borner C, Almeida L, Salvayre R, Negre-Salvayre A. Oxidized LD. Ls alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis. FASEB J. 2000;14:532-542.
21. McConkey DJ, Hartzell P, Nicotera P, Orrenius S. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J. 1989;3: 1843-1849.
22. De Duve C, Pressman BC, Gianetto R, Wattiaux R, Appelmans F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J. 1955;60:604-609.
23. Chen M, He H, Zhan S, Krajewski S, Reed JC, Gottlieb RA. Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion. J Biol Chem. 2001;276:30724-30728.
24. Padma S, Subramanyam C. Extracellular calcineurin: identification and quantitation in serum and amniotic fluid. Clin Biochem. 1999;32: 491-494.
25. Garcia-Calvo M, Peterson EP, Rasper DM, Vaillancourt JP, Zamboni R, Nicholson DW, Thornberry NA. Purification and catalytic properties of human caspase family members. Cell Death Differ. 1999;6:362-369.
26. Auge N, Garcia V, Maupas-Schwalm F, Levade T, Salvayre R, Negre-Salvayre A. Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. Arterioscler Thromb Vasc Biol. 2002;22:1990-1995.
27. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. 1999;341:233-249.
28. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med. 2000;6:513-519.
29. Bernardi P, Petronilli V, Di Iisa F, Forte M. A mitochondrial perspective on cell death. Trends Biochem Sci. 2001;26:112-117.
30. Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 2003;112:481-490.
31. Rusinol AE, Yang L, Thewke D, Panini SR, Kramer MF, Sinensky MS. Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein. J Biol Chem. 2000;275:7296-7303.
32. Negre-Salvayre A, Salvayre R. Protection by Ca2+ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized LDL to cultured lymphoid cells. Br J Pharmacol. 1992;107:738-744.
33. Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem. 2002;277:13430-13437.
34. Henry-Mowatt J, Dive C, Martinou JC, James D. Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene. 2004;23: 2850-2860.
35. Zhao Y, Ding WX, Qian T, Watkins S, Lemasters JJ, Yin XM. Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology. 2003;125: 854-867.
36. Vacaresse N, Vieira O, Robbesyn F, Jurgens G, Salvayre R, Negre-Salvayre A. Phenolic antioxidants trolox and caffeic acid modulate the oxidized LDL-induced EGF-receptor activation. Br J Pharmacol. 2001; 132:1777-1788.
37. Rusnak F, Reiter T. Sensing electrons: protein phosphatase redox regulation. Trends Biochem Sci. 2000;25:527-529.
38. Cande C, Cecconi F, Dessen P, Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci. 2002;115:4727-4734.
39. Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome C release in response to several proapoptotic stimuli. J Cell Biol. 2002;159:923-929.
40. Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. 2004;23:2785-2796.