-
1
-
-
84862622024
-
FGF21: the center of a transcriptional nexus in metabolic regulation
-
Adams A.C., Kharitonenkov A. FGF21: the center of a transcriptional nexus in metabolic regulation. Curr. Diab. Rev. 2012, 8:285-293.
-
(2012)
Curr. Diab. Rev.
, vol.8
, pp. 285-293
-
-
Adams, A.C.1
Kharitonenkov, A.2
-
2
-
-
77951995518
-
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner
-
Adams A.C., Astapova I., Fisher F.M., Badman M.K., Kurgansky K.E., Flier J.S., Hollenberg A.N., Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J. Biol. Chem. 2010, 285:14078-14082.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14078-14082
-
-
Adams, A.C.1
Astapova, I.2
Fisher, F.M.3
Badman, M.K.4
Kurgansky, K.E.5
Flier, J.S.6
Hollenberg, A.N.7
Maratos-Flier, E.8
-
3
-
-
84905679771
-
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
-
Adams A.C., Yang C., Coskun T., Cheng C.C., Gimeno R.E., Luo Y., Kharitonenkov A. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Molecular Metabolism 2013, 2:31-37.
-
(2013)
Molecular Metabolism
, vol.2
, pp. 31-37
-
-
Adams, A.C.1
Yang, C.2
Coskun, T.3
Cheng, C.C.4
Gimeno, R.E.5
Luo, Y.6
Kharitonenkov, A.7
-
4
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J., Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007, 5:426-437.
-
(2007)
Cell Metab.
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.5
Maratos-Flier, E.6
-
5
-
-
85027909934
-
Adipose tissue browning and metabolic health
-
Bartelt A., Heeren J. Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 2014, 10:24-36.
-
(2014)
Nat. Rev. Endocrinol.
, vol.10
, pp. 24-36
-
-
Bartelt, A.1
Heeren, J.2
-
6
-
-
84883778996
-
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
-
Bookout A.L., de Groot M.H.M., Owen B.M., Lee S., Gautron L., Lawrence H.L., Ding X., Elmquist J.K., Takahashi J.S., Mangelsdorf D.J., Kliewer S.A. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat. Med. 2013, 19:1147-1152.
-
(2013)
Nat. Med.
, vol.19
, pp. 1147-1152
-
-
Bookout, A.L.1
de Groot, M.H.M.2
Owen, B.M.3
Lee, S.4
Gautron, L.5
Lawrence, H.L.6
Ding, X.7
Elmquist, J.K.8
Takahashi, J.S.9
Mangelsdorf, D.J.10
Kliewer, S.A.11
-
7
-
-
17844381294
-
Short photoperiod exposure increases adipocyte sensitivity to noradrenergic stimulation in Siberian hamsters
-
Bowers R.R., Gettys T.W., Prpic V., Harris R.B., Bartness T.J. Short photoperiod exposure increases adipocyte sensitivity to noradrenergic stimulation in Siberian hamsters. Am. J. Physiol. 2005, 288:R1354-R1360.
-
(2005)
Am. J. Physiol.
, vol.288
-
-
Bowers, R.R.1
Gettys, T.W.2
Prpic, V.3
Harris, R.B.4
Bartness, T.J.5
-
8
-
-
0347989317
-
Brown adipose tissue: function and physiological significance
-
Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
9
-
-
79960743932
-
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
-
Chartoumpekis D.V., Habeos I.G., Ziros P.G., Psyrogiannis A.I., Kyriazopoulou V.E., Papavassiliou A.G. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol. Med. 2011, 17:736-740.
-
(2011)
Mol. Med.
, vol.17
, pp. 736-740
-
-
Chartoumpekis, D.V.1
Habeos, I.G.2
Ziros, P.G.3
Psyrogiannis, A.I.4
Kyriazopoulou, V.E.5
Papavassiliou, A.G.6
-
10
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun T., Bina H.A., Schneider M.A., Dunbar J.D., Hu C.C., Chen Y., Moller D.E., Kharitonenkov A. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 2008, 149:6018-6027.
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
Bina, H.A.2
Schneider, M.A.3
Dunbar, J.D.4
Hu, C.C.5
Chen, Y.6
Moller, D.E.7
Kharitonenkov, A.8
-
11
-
-
0036087731
-
Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus)
-
Demas G.E., Bowers R.R., Bartness T.J., Gettys T.W. Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus). Am. J. Physiol. 2002, 282:R114-R121.
-
(2002)
Am. J. Physiol.
, vol.282
-
-
Demas, G.E.1
Bowers, R.R.2
Bartness, T.J.3
Gettys, T.W.4
-
12
-
-
77955474305
-
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
-
Dushay J., Chui P.C., Gopalakrishnan G.S., Varela-Rey M., Crawley M., Fisher F.M., Badman M.K., Martinez-Chantar M.L., Maratos-Flier E. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 2010, 139:456-463.
-
(2010)
Gastroenterology
, vol.139
, pp. 456-463
-
-
Dushay, J.1
Chui, P.C.2
Gopalakrishnan, G.S.3
Varela-Rey, M.4
Crawley, M.5
Fisher, F.M.6
Badman, M.K.7
Martinez-Chantar, M.L.8
Maratos-Flier, E.9
-
13
-
-
0028103786
-
Photoperiodic differences during development in the dwarf hamsters Phodopus sungorus and Phodopus campbelli
-
Ebling F.J.P. Photoperiodic differences during development in the dwarf hamsters Phodopus sungorus and Phodopus campbelli. Gen. Comp. Endocrinol. 1994, 95:475-482.
-
(1994)
Gen. Comp. Endocrinol.
, vol.95
, pp. 475-482
-
-
Ebling, F.J.P.1
-
14
-
-
45549087105
-
The regulation of seasonal changes in food intake and body weight
-
Ebling F.J.P., Barrett P. The regulation of seasonal changes in food intake and body weight. J. Neuroendocrinol. 2008, 20:827-833.
-
(2008)
J. Neuroendocrinol.
, vol.20
, pp. 827-833
-
-
Ebling, F.J.P.1
Barrett, P.2
-
15
-
-
78049297991
-
Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
-
Fisher F.M., Chui P.C., Antonellis P.J., Bina H.A., Kharitonenkov A., Flier J.S., Maratos-Flier E. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010, 59:2781-2789.
-
(2010)
Diabetes
, vol.59
, pp. 2781-2789
-
-
Fisher, F.M.1
Chui, P.C.2
Antonellis, P.J.3
Bina, H.A.4
Kharitonenkov, A.5
Flier, J.S.6
Maratos-Flier, E.7
-
16
-
-
84863012022
-
FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis
-
Fisher F.M., Kleiner S., Fox E.C., Mepani R.J., Verdeguer J., Wu J., Kharitonenkov A., Flier J.S., Maratos-Flier E., Spiegelman B.M. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012, 26:271-281.
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Fox, E.C.3
Mepani, R.J.4
Verdeguer, J.5
Wu, J.6
Kharitonenkov, A.7
Flier, J.S.8
Maratos-Flier, E.9
Spiegelman, B.M.10
-
18
-
-
84874616515
-
Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities
-
Hager T., Spahr C., Xu J., Salimi-Moosavi H., Hall M. Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities. Anal. Chem. 2013, 85(5):2731-2738.
-
(2013)
Anal. Chem.
, vol.85
, Issue.5
, pp. 2731-2738
-
-
Hager, T.1
Spahr, C.2
Xu, J.3
Salimi-Moosavi, H.4
Hall, M.5
-
19
-
-
50849100676
-
Ancestral TSH mechanism signals summer in a photoperiodic mammal
-
Hanon E.A., Lincoln G.A., Fustin J.M., Dardente H., Masson-Pevet M., Morgan P.J., Hazlerigg D.G. Ancestral TSH mechanism signals summer in a photoperiodic mammal. Curr. Biol. 2008, 18:1147-1152.
-
(2008)
Curr. Biol.
, vol.18
, pp. 1147-1152
-
-
Hanon, E.A.1
Lincoln, G.A.2
Fustin, J.M.3
Dardente, H.4
Masson-Pevet, M.5
Morgan, P.J.6
Hazlerigg, D.G.7
-
20
-
-
0022365783
-
Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation
-
Heldmaier G., Buchberger A. Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation. J. Comp. Physiol. B. 1985, 156:237-245.
-
(1985)
J. Comp. Physiol. B.
, vol.156
, pp. 237-245
-
-
Heldmaier, G.1
Buchberger, A.2
-
21
-
-
0020307269
-
Nonshivering thermogenesis and cold resistance during seasonal acclimatization in the Djungarian hamster
-
Heldmaier G., Steinlechner S., Rafael J. Nonshivering thermogenesis and cold resistance during seasonal acclimatization in the Djungarian hamster. J. Comp. Physiol. 1982, 149:1-9.
-
(1982)
J. Comp. Physiol.
, vol.149
, pp. 1-9
-
-
Heldmaier, G.1
Steinlechner, S.2
Rafael, J.3
-
22
-
-
0033045145
-
Metabolic adjustments during daily torpor in the Djungarian hamster
-
Heldmaier G., Klingenspor M., Werneyer M., Lampi B.J., Brooks S.P., Storey K.B. Metabolic adjustments during daily torpor in the Djungarian hamster. Am. J. Physiol. 1999, 276:E896-E906.
-
(1999)
Am. J. Physiol.
, vol.276
-
-
Heldmaier, G.1
Klingenspor, M.2
Werneyer, M.3
Lampi, B.J.4
Brooks, S.P.5
Storey, K.B.6
-
23
-
-
79953886306
-
Thermogenic activation induces FGF21 expression and release in brown adipose tissue
-
Hondares E., Iglesias R., Giralt A., Gonzales F.J., Giralt M., Mampel T., Villarroya F. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 2011, 286:12983-12990.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 12983-12990
-
-
Hondares, E.1
Iglesias, R.2
Giralt, A.3
Gonzales, F.J.4
Giralt, M.5
Mampel, T.6
Villarroya, F.7
-
24
-
-
36148970418
-
The fasting polypeptide FGF21 can enter brain from blood
-
Hsuchou H., Pan W., Kastin A.J. The fasting polypeptide FGF21 can enter brain from blood. Peptides 2007, 28:2382-2386.
-
(2007)
Peptides
, vol.28
, pp. 2382-2386
-
-
Hsuchou, H.1
Pan, W.2
Kastin, A.J.3
-
25
-
-
34249686631
-
Endocrine regulation of the fasting response by PPAR-mediated induction of fibroblast growth factor 21
-
Inagaki T., Dutchak P., Zhao G., Ding X., Gautron L., Parameswara V., Li Y., Goetz R., Mohammadi M., Esser V., Elmquist J.K., Gerard R.D., Burgess S.C., Hammer R.E., Mangelsdorf D.J., Kliewer S.A. Endocrine regulation of the fasting response by PPAR-mediated induction of fibroblast growth factor 21. Cell Metab. 2007, 5:415-425.
-
(2007)
Cell Metab.
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
Parameswara, V.6
Li, Y.7
Goetz, R.8
Mohammadi, M.9
Esser, V.10
Elmquist, J.K.11
Gerard, R.D.12
Burgess, S.C.13
Hammer, R.E.14
Mangelsdorf, D.J.15
Kliewer, S.A.16
-
26
-
-
70350093621
-
Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
-
Johnson C.L., Chadi S.A., Fazio E.N., Huff M.W., Kharitonenkov A., Koester A., Pin C.L. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Gastroenterology 2009, 137:1795-1804.
-
(2009)
Gastroenterology
, vol.137
, pp. 1795-1804
-
-
Johnson, C.L.1
Chadi, S.A.2
Fazio, E.N.3
Huff, M.W.4
Kharitonenkov, A.5
Koester, A.6
Pin, C.L.7
-
27
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.S., Mehrbod F., Jaskunas S.R., Shanafelt A.B. FGF-21 as a novel metabolic regulator. J. Clin. Investig. 2005, 115:1627-1635.
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.S.15
Mehrbod, F.16
Jaskunas, S.R.17
Shanafelt, A.B.18
-
28
-
-
39149091423
-
FGF-21/FGF-21 receptor interaction and activation is determined by beta Klotho
-
Kharitonenkov A., Dunbar J.D., Bina H.A., Bright S., Moyers J.S., Zhang C., Ding L., Micanovic R., Mehrbod S.F., Knierman M.D., Hale J.E., Coskun T., Shanafelt A.B. FGF-21/FGF-21 receptor interaction and activation is determined by beta Klotho. J. Cell. Physiol. 2008, 215:1-7.
-
(2008)
J. Cell. Physiol.
, vol.215
, pp. 1-7
-
-
Kharitonenkov, A.1
Dunbar, J.D.2
Bina, H.A.3
Bright, S.4
Moyers, J.S.5
Zhang, C.6
Ding, L.7
Micanovic, R.8
Mehrbod, S.F.9
Knierman, M.D.10
Hale, J.E.11
Coskun, T.12
Shanafelt, A.B.13
-
29
-
-
65249162834
-
Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver
-
Klieverik L.P., Janssen S.F., van Riel A., Foppen E., Bisschop P.A., Serlie M.J., Boelen A., Ackerman M.T., Sauerwein H.P., Fliers E., Kalsbeek A. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:5966-5971.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 5966-5971
-
-
Klieverik, L.P.1
Janssen, S.F.2
van Riel, A.3
Foppen, E.4
Bisschop, P.A.5
Serlie, M.J.6
Boelen, A.7
Ackerman, M.T.8
Sauerwein, H.P.9
Fliers, E.10
Kalsbeek, A.11
-
30
-
-
84455160781
-
Effects of manipulating hypothalamic tri-iodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters
-
Murphy M., Jethwa P.H., Warner A., Barrett P., Nilaweera K.N., Brameld J.M., Ebling F.J.P. Effects of manipulating hypothalamic tri-iodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters. Endocrinology 2012, 153:101-112.
-
(2012)
Endocrinology
, vol.153
, pp. 101-112
-
-
Murphy, M.1
Jethwa, P.H.2
Warner, A.3
Barrett, P.4
Nilaweera, K.N.5
Brameld, J.M.6
Ebling, F.J.P.7
-
31
-
-
84873040644
-
Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity
-
Murphy M., Samms R., Warner A., Bolborea M., Barrett P., Fowler M.J., Brameld J.M., Tsintzas K., Kharitonenkov A., Adams A.C., Coskun T., Ebling F.J.P. Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity. J. Neuroendocrinol. 2013, 25:180-189.
-
(2013)
J. Neuroendocrinol.
, vol.25
, pp. 180-189
-
-
Murphy, M.1
Samms, R.2
Warner, A.3
Bolborea, M.4
Barrett, P.5
Fowler, M.J.6
Brameld, J.M.7
Tsintzas, K.8
Kharitonenkov, A.9
Adams, A.C.10
Coskun, T.11
Ebling, F.J.P.12
-
32
-
-
84871784780
-
Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
-
Nelson B.T., Ding X., Boney-Montoya J., Gerard R.D., Kliewer S.A., Andrews M.T. Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. PLoS ONE 2013, 8:e53574.
-
(2013)
PLoS ONE
, vol.8
-
-
Nelson, B.T.1
Ding, X.2
Boney-Montoya, J.3
Gerard, R.D.4
Kliewer, S.A.5
Andrews, M.T.6
-
33
-
-
0034697846
-
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
-
Nishimura T., Nakatake Y., Konishi M., Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta 2000, 1492:203-206.
-
(2000)
Biochim. Biophys. Acta
, vol.1492
, pp. 203-206
-
-
Nishimura, T.1
Nakatake, Y.2
Konishi, M.3
Itoh, N.4
-
34
-
-
84883763046
-
FGF21 contributes to neuroendocrine control of female reproduction
-
Owen B.M., Bookout A.L., Ding X., Lin V.Y., Atkin S.D., Gautron L., Kliewer S.A., Mangelsdorf D.J. FGF21 contributes to neuroendocrine control of female reproduction. Nat. Med. 2013, 19:1153-1156.
-
(2013)
Nat. Med.
, vol.19
, pp. 1153-1156
-
-
Owen, B.M.1
Bookout, A.L.2
Ding, X.3
Lin, V.Y.4
Atkin, S.D.5
Gautron, L.6
Kliewer, S.A.7
Mangelsdorf, D.J.8
-
35
-
-
84879666287
-
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
-
Planavila A., Redondo I., Hondares E., Vinciguerra M., Munts C., Iglesias R., Gabrielli L.A., Sitges M., Giralt M., van Bilsen M., Villarroya F. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Nat. Commun. 2013, 4:2019. 10.1038/ncomms3019.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2019
-
-
Planavila, A.1
Redondo, I.2
Hondares, E.3
Vinciguerra, M.4
Munts, C.5
Iglesias, R.6
Gabrielli, L.A.7
Sitges, M.8
Giralt, M.9
van Bilsen, M.10
Villarroya, F.11
-
36
-
-
77954277205
-
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
-
Sarruf D.A., Thaler J.P., Morton G.J., German J., Fischer J.D., Ogimoto K., Schwartz M.W. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 2010, 59:1817-1824.
-
(2010)
Diabetes
, vol.59
, pp. 1817-1824
-
-
Sarruf, D.A.1
Thaler, J.P.2
Morton, G.J.3
German, J.4
Fischer, J.D.5
Ogimoto, K.6
Schwartz, M.W.7
-
37
-
-
77951757577
-
Effects of photoperiod on daily locomotor activity, energy expenditure and feeding behavior in a seasonal mammal
-
Warner A., Jethwa P.H., Wyse C.A., I'Anson H., Brameld J.M., Ebling F.J.P. Effects of photoperiod on daily locomotor activity, energy expenditure and feeding behavior in a seasonal mammal. Am. J. Physiol. 2010, 298:R1409-R1416.
-
(2010)
Am. J. Physiol.
, vol.298
-
-
Warner, A.1
Jethwa, P.H.2
Wyse, C.A.3
I'Anson, H.4
Brameld, J.M.5
Ebling, F.J.P.6
-
38
-
-
48349146527
-
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
-
Zhang X., Yeung D.C., Karpisek M., Stejskal D., Zhou Z.G., Liu F., Wong R.L., Chow W.S., Tso A.W., Lam K.S., Xu A. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008, 57:1246-1253.
-
(2008)
Diabetes
, vol.57
, pp. 1246-1253
-
-
Zhang, X.1
Yeung, D.C.2
Karpisek, M.3
Stejskal, D.4
Zhou, Z.G.5
Liu, F.6
Wong, R.L.7
Chow, W.S.8
Tso, A.W.9
Lam, K.S.10
Xu, A.11
|