Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 853-860

  Briz, Oscar ^a   Serrano, Maria Angeles ^a   Rebollo, Noemi ^a   Hagenbuch, Bruno ^a   Meier, Peter J ^a   Koepsell, Hermann ^b   Marin, Jose J G ^c  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; BILE ACID; BUTYRIC ACID; CARRIER PROTEIN; CATION; CHLORIDE; CIS DIAMMINEBISURSODEOXYCHOLATE PLATINUM; CIS DIAMMINECHLOROCHOLYLGLYCINATE PLATINUM; CISPLATIN DERIVATIVE; GLYCOCHOLIC ACID; OUABAIN; POLYPEPTIDE; QUININE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATOMIC ABSORPTION; CHO CELL; CONTROLLED STUDY; DRUG UPTAKE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; XENOPUS LAEVIS;

ANIMALS; ANIONS; ANTINEOPLASTIC AGENTS; BILE ACIDS AND SALTS; CATIONS; CHO CELLS; CRICETINAE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HEPATOCYTES; HUMANS; LIVER; OOCYTES; ORGANOPLATINUM COMPOUNDS; TUMOR CELLS, CULTURED; URSODEOXYCHOLIC ACID; XENOPUS LAEVIS;

EID: 0036211864     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.853     Document Type: Article

References (40)

1. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
2. Influence of side-chain charge on hepatic transport of bile acids and bile acid analogues
3. +/bile acid cotransporter
4. Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair
5. Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate (O,O′) Pt(II) and cis-diamminebisursodeoxycholate (O,O′) Pt(II) complexes
6. Synthesis and characterization of a new bile acid and platinum(II) complex with cytostatic activity
7. Synthesis and characterization of the new cytostatic complex cis-diammineplatinum (II)-chlorocholylglycinate
8. Low in vivo toxicity of a novel cisplatin-ursodeoxycholic derivative (Bamet-UD2) with enhanced cytostatic activity versus liver tumors
9. Polyspecific substrate uptake by the hepatic organic anion transporter Oatpl in stably transfected CHO cells
10. Cloning and characterization of two human polyspecific organic cation transporters
11. Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X
12. +/bile acid cotransporter in Xenopus laevis oocytes
13. + bile acid cotransporter
14. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes
15. Utilizing bile acid carrier mechanisms to enhance liver and small intestine absorption
16. Organic cation transporters in intestine, kidney, liver, and brain
17. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
18. Liver-specific drug targeting by coupling to bile acids
19. Chlorambucil taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas
20. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
21. Liver organotropism and biotransformation of a novel platinumursodeoxycholate derivative, Bamet-UD2, with enhanced antitumor activity
22. Differential expression of the polyspecific drug transporter Octl in rat hepatocarcinoma
23. +-taurocholate cotransport and its encoding messenger RNA in primary cultures of rat hepatocytes
24. Cholephilic characteristics of a new cytostatic complex of cisplatin with glycocholate (Bamet-R2)
25. Transport and biotransformation of the new cytostatic complex cis-diammmineplatinum (II)-chlorocholylglycinate (Bamet-R2) by the rat liver
26. Rat liver transport and biotransformation of a cytostatic complex of bis-cholylglycinate and platinum(II)
27. DNA interaction and cytostatic activity of the new liver organotropic complex of cisplatin with glycocholic acid: Bamet-R2
28. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
29. Relationship between DNA-reactivity and cytostatic activity of two novel bile acid-platinum derivatives, Bamet-UD2 and Bamet-D3
30. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
31. Further evidence of the usefulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors
32. Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes
33. Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression
34. +-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells
35. The coordination chemistry of platinum anticancer drugs and related compounds with DNA
36. Tissue selective drug delivery utilizing carrier-mediated transport systems
37. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations
38. Comparison of"type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides
39. Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21 methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system
40. Cloning and functional expression of a human liver organic cation transporter