Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 6, 2014, Pages 1720-1727

  Hatchwell, Luke ^a,b   Girkin, Jason ^a,b   Dun, Matthew D ^a,c   Morten, Matthew ^a,b   Verrills, Nicole ^a,c   Toop, Hamish D ^d   Morris, Jonathan C ^d   Johnston, Sebastian L ^e   Foster, Paul S ^b   Collison, Adam ^a,b   Mattes, Joerg ^a,b,f  

^a HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^f Paediatric Respiratory and Sleep Medicine Unit Newcastle Children's Hospital   (Australia)

Author keywords

(S) 2 amino 4 (4 heptyloxy phenyl) 2 methylbutan 1 ol; allergy; asthma; chemokine; dexamethasone; exacerbation; formoterol; nuclear factor B; protein phosphatase 2A; rhinovirus; salbutamol; salmeterol

Indexed keywords

2 AMINO 4 (4 (HEPTYLOXY)PHENYL) 2 METHYLBUTAN 1 OL; ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CCL1 CHEMOKINE; CXCL2 CHEMOKINE; DEXAMETHASONE; FORMOTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN PHOSPHATASE 2A; SALBUTAMOL; SALMETEROL; UNCLASSIFIED DRUG; 2 AMINO 4 [4 (HEPTYLOXY)PHENYL] 2 METHYLBUTAN 1 OL; ENZYME ACTIVATOR; EOTAXIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS HYPERREACTIVITY; CHEMOTAXIS; CONTROLLED STUDY; DERMATOPHAGOIDES; DISEASE EXACERBATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EOSINOPHIL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; RHINOVIRUS; RNA INTERFERENCE; SYSTEMIC THERAPY; ANIMAL CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REACTIVATION; EOSINOPHILIA; IMMUNOMODULATION; RHINOVIRUS INFECTION;

(S)-2-AMINO-4-(4-[HEPTYLOXY]PHENYL)-2-METHYLBUTAN-1-OL; ALLERGY; ASTHMA; CHEMOKINE; DEXAMETHASONE; EXACERBATION; FORMOTEROL; LONG-ACTING Β(2)-AGONIST; NUCLEAR FACTOR ΚB; PROTEIN PHOSPHATASE 2A; RHINOVIRUS; SALBUTAMOL; SALMETEROL;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; CHEMOTAXIS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EOSINOPHILS; INFLAMMATION; MALE; MICE; NEUTROPHILS; PICORNAVIRIDAE INFECTIONS; PROTEIN PHOSPHATASE 2; RESPIRATORY HYPERSENSITIVITY; RHINOVIRUS;

EID: 84901793767     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.11.014     Document Type: Article

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