Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15833-15842

  Don, Anthony S ^a   Martinez Lamenca, Carolina ^a   Webb, William R ^a   Proia, Richard L ^b   Roberts, Ed ^a   Rosen, Hugh ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c ICND118 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE MODELS; IMMUNOSUPPRESSANT; SPHINGOSINE KINASE; SPHINGOSINE KINASE 2 (SPHK2);

CELL CULTURE; CELL DEATH; IMMUNOLOGY; MUTAGENESIS; PATHOGENS; PHOSPHORYLATION;

ENZYME ACTIVITY;

2 AMINO 4 (4 HEPTYLOXYPHENYL) 2 METHYLBUTANOL; ETOPOSIDE; FINGOLIMOD; SPHINGOLIPID; SPHINGOSINE DERIVATIVE; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG; CASPASE; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; PHOSPHOTRANSFERASE; PROPANEDIOL DERIVATIVE; PROTEIN BAX; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE; LYMPHOPROLIFERATIVE DISEASE; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPLEEN; THYMUS; ANIMAL; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; HELA CELL; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PROTEIN TRANSPORT;

MUS; SPHINGOIDEA;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; BCL-2-ASSOCIATED X PROTEIN; CALCIUM SIGNALING; CASPASES; CELL MEMBRANE PERMEABILITY; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JURKAT CELLS; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUTAGENESIS; ORGAN SPECIFICITY; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; PROTEIN TRANSPORT; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOLIPIDS; SPHINGOSINE; SPLEEN; THYMUS GLAND;

EID: 34447530934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609124200     Document Type: Article

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