Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways

Biochemical and Biophysical Research Communications

Volumn 449, Issue 1, 2014, Pages 88-93

  Xie, Qiang ^a,b   Zhou, Yangliang ^a   Lan, Guoqiang ^a   Yang, Liye ^a   Zheng, Wenjie ^a   Liang, Yuanwei ^a   Chen, Tianfeng ^a  

^a JINAN UNIVERSITY   (China)

^b Wu Jing Zong Dui Hospital of Guangdong Province   (China)

Author keywords

Radiotherapy; Selenadiazole derivative; Signaling; Thioredoxin reductase

Indexed keywords

1,2,3 SELENADIAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PYRROLE DERIVATIVE; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; SELENIUM DERIVATIVE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG;

A375 CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME INACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HELA CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIZATION; WESTERN BLOTTING;

RADIOTHERAPY; SELENADIAZOLE DERIVATIVE; SIGNALING; THIOREDOXIN REDUCTASE;

APOPTOSIS; AZOLES; CELL SURVIVAL; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MELANOMA; ONCOGENE PROTEIN V-AKT; ORGANOSELENIUM COMPOUNDS; QUINOXALINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 84901787638     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.151     Document Type: Article

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