Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

PLoS Genetics

Volumn 10, Issue 2, 2014, Pages

  Huser, Camille A ^a   Gilroy, Kathryn L ^a   de Ridder, Jeroen ^b   Kilbey, Anna ^a   Borland, Gillian ^a   Mackay, Nancy ^a   Jenkins, Alma ^a   Bell, Margaret ^a   Herzyk, Pawel ^a   van der Weyden, Louise ^c   Adams, David J ^c   Rust, Alistair G ^c   Cameron, Ewan ^a   Neil, James C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CHEMOKINE RECEPTOR CCR7; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR RUNX2; IKAROS TRANSCRIPTION FACTOR; PROTEIN P53; ZFPN1A1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CCR7 GENE; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE TARGETING; GFI1 GENE; IKZF1 GENE; LYMPHOMA; LYMPHOMAGENESIS; MOUSE; NEWBORN; NONHUMAN; NOTCH1 GENE; ONCOGENE MYC; PARACRINE SIGNALING; RUNX2 GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; WILD TYPE; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETICS; GERM CELL; HIGH THROUGHPUT SEQUENCING; HUMAN; MOLONEY LEUKEMIA ONCOVIRUS; ONCOGENE MYB; PATHOLOGY; VIROLOGY;

ANIMALS; CARCINOGENESIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GENES, MYB; GERM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IKAROS TRANSCRIPTION FACTOR; LYMPHOMA; MICE; MOLONEY MURINE LEUKEMIA VIRUS; MUTAGENESIS, INSERTIONAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84901743776     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004167     Document Type: Article

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