Three murine leukemia virus integration regions within 100 kilobases upstream of c-myb are proximal to the 5' regulatory region of the gene through DNA looping

Journal of Virology

Volumn 86, Issue 19, 2012, Pages 10524-10532

  Zhang, Junfang ^a   Markus, Jan ^a,b   Bies, Juraj ^a   Paul, Thomas ^a,c   Wolff, Linda ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CANCER RESEARCH INSTITUTE   (Slovakia)

^c CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C MYB;

ANIMAL CELL; ARTICLE; BONE MARROW CULTURE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DETERMINATION; DNA LOOPING; DNA STRUCTURE; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; HISTONE MODIFICATION; MICROARRAY ANALYSIS; MURINE LEUKEMIA VIRUS; MYELOID LEUKEMIA; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYB; PRIORITY JOURNAL; PROMOTER REGION; PROVIRUS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL; VIRUS DNA CELL DNA INTERACTION;

3T3 CELLS; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DNA; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; GENES, MYB; HISTONES; LEUKEMIA VIRUS, MURINE; MICE; MODELS, BIOLOGICAL; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYB; RETROVIRIDAE;

MURINAE; MURINE LEUKEMIA VIRUS; MUS;

EID: 84869038204     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01077-12     Document Type: Article

References (42)

1. Barski A, et al. 2007. High-resolution profiling of histone methylations in the human genome. Cell 129:823-837.
2. Bender TP, Thompson CB, Kuehl WM. 1987. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 237:1473-1476.
3. Clappier E, et al. 2007. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 110:1251-1261.
4. Daniel R, Smith JA. 2008. Integration site selection by retroviral vectors: molecular mechanism and clinical consequences. Hum. Gene Ther. 19: 557-568.
5. Dekker J, Rippe K, Dekker M, Kleckner N. 2002. Capturing chromosome conformation. Science 295:1306-1311.
6. Drabsch Y, et al. 2007. Mechanism of and requirement for estrogenregulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 104:13762-13767.
7. Greig KT, Carotta S, Nutt SL. 2008. Critical roles for c-Myb in hematopoietic progenitor cells. Semin. Immunol. 20:247-256.
8. Hagege H, et al. 2007. Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat. Protoc. 2:1722-1733.
9. Haviernik P, et al. 2002. Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia. J. Gen. Virol. 83: 819-827.
10. Heintzman ND, et al. 2009. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459:108-112.
11. Heintzman ND, et al. 2007. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39:311-318.
12. Hou CH, Zhao H, Tanimoto K, Dean A. 2008. CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc. Natl. Acad. Sci. U. S. A. 105:20398-20403.
13. Hugo H, et al. 2006. Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer 45: 1143-1154.
14. Kagey MH, et al. 2010. Mediator and cohesin connect gene expression and chromatin architecture. Nature 467:430-435.
15. Koch CM, et al. 2007. The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 17:691-707.
16. Koller R, et al. 1996. Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10. Virology 224:224-234.
17. Kouzarides T. 2007. Chromatin modifications and their function. Cell 128:693-705.
18. Lahortiga I, et al. 2007. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat. Genet. 39:593-595.
19. Lewinski MK, et al. 2006. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog. 2:611-622. doi: 10.1371/journal.ppat.0020060.
20. Liebermann DA, Hoffman-Liebermann B. 1989. Proto-oncogene expression and dissection of the myeloid growth to differentiation developmental cascade. Oncogene 4:583-592.
21. Lieu YK, Reddy EP. 2009. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc. Natl. Acad. Sci. U. S. A. 106: 21689-21694.
22. Maeda N, Fan H, Yoshikai Y. 2008. Oncogenesis by retroviruses: old and new paradigms. Rev. Med. Virol. 18:387-405.
23. Mirkovitch J, Mirault ME, Laemmli UK. 1984. Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold. Cell 39:223-232.
24. Morse RH. 2010. Epigenetic marks identify functional elements. Nat. Genet. 42:282-284.
25. Mukai HY, et al. 2006. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol. Cell. Biol. 26:7953-7965.
26. Nason-Burchenal K, Wolff L. 1993. Activation of c-myb is an early bonemarrow event in a murine model for acute promonocytic leukemia. Proc. Natl. Acad. Sci. U. S. A. 90:1619-1623.
27. Neel BG, Hayward WS, Robinson HL, Fang J, Astrin SM. 1981. Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion. Cell 23:323-334.
28. Paul TA, Bies J, Small D, Wolff L. 2010. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. Blood 115:3098-3108.
29. Phillips JE, Corces VG. 2009. CTCF: master weaver of the genome. Cell 137:1194-1211.
30. Ramsay RG, Gonda TJ. 2008. MYB function in normal and cancer cells. Nat. Rev. Cancer 8:523-534.
31. Reddy CD, Reddy EP. 1989. Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression. Proc. Natl. Acad. Sci. U. S. A. 86:7326-7330.
32. Schmidt M, Nazarov V, Stevens L, Watson R, Wolff L. 2000. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Mol. Cell. Biol. 20:1970-1981.
33. Shen-Ong GL, Wolff L. 1987. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. J. Virol. 61:3721-3725.
34. Slape C, et al. 2007. Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res. 67:5148-5155.
35. Splinter E, et al. 2006. CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev. 20:2349-2354.
36. Stadhouders R, et al. 2011. Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J. 31:986-999.
37. Thompson MA, Flegg R, Westin EH, Ramsay RG. 1997. Microsatellite deletions in the c-myb transcriptional attenuator region associated with over-expression in colon tumour cell lines. Oncogene 14:1715-1723.
38. Wahlberg K, et al. 2009. The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells. Blood 114:1254-1262.
39. Wang Z, et al. 2009. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138:1019-1031.
40. Wolff L. 1996. Myb-induced transformation. Crit. Rev. Oncogenesis 7:245-260.
41. Wolff L, Koller R, Davidson W. 1991. Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): clonal integrations involve c-myb in some but not all leukemias. J. Virol. 65:3607-3616.
42. Wolff L, Mushinski JF, Shen-Ong GL, Morse HC, III. 1988. A chronic inflammatory response. Its role in supporting the development of c-myb and c-myc related promonocytic and monocytic tumors in BALB/c mice. J. Immunol. 141:681-689.