-
1
-
-
0034724857
-
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
-
Cavazzana-Calvo, M, Hacein-Bey, S, de Saint Basile, G, Gross, F, Yvon, E, Nusbaum, P et al. (2000). Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288: 669-672.
-
(2000)
Science
, vol.288
, pp. 669-672
-
-
Cavazzana-Calvo, M.1
Hacein-Bey, S.2
de Saint Basile, G.3
Gross, F.4
Yvon, E.5
Nusbaum, P.6
-
2
-
-
34249906359
-
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
-
Deichmann, A, Hacein-Bey-Abina, S, Schmidt, M, Garrigue, A, Brugman, MH, Hu, J et al. (2007). Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest 117: 2225-2232.
-
(2007)
J Clin Invest
, vol.117
, pp. 2225-2232
-
-
Deichmann, A.1
Hacein-Bey-Abina, S.2
Schmidt, M.3
Garrigue, A.4
Brugman, M.H.5
Hu, J.6
-
3
-
-
34547651095
-
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
-
Schwarzwaelder, K, Howe, SJ, Schmidt, M, Brugman, MH, Deichmann, A, Glimm, H et al. (2007). Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest 117: 2241-2249.
-
(2007)
J Clin Invest
, vol.117
, pp. 2241-2249
-
-
Schwarzwaelder, K.1
Howe, S.J.2
Schmidt, M.3
Brugman, M.H.4
Deichmann, A.5
Glimm, H.6
-
4
-
-
0037448352
-
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
-
Hacein-Bey-Abina, S, von Kalle, C, Schmidt, M, Le Deist, F, Wulffraat, N, McIntyre, E et al. (2003). A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348: 255-256.
-
(2003)
N Engl J Med
, vol.348
, pp. 255-256
-
-
Hacein-Bey-Abina, S.1
von Kalle, C.2
Schmidt, M.3
Le Deist, F.4
Wulffraat, N.5
McIntyre, E.6
-
5
-
-
0033118161
-
The effect of chromosomal translocations in acute leukemias: The LMO2 paradigm in transcription and development
-
Rabbitts, TH, Bucher, K, Chung, G, Grutz, G, Warren, A and Yamada, Y (1999). The effect of chromosomal translocations in acute leukemias: The LMO2 paradigm in transcription and development. Cancer Res 59 1794s-1798s.
-
(1999)
Cancer Res
, vol.59
-
-
Rabbitts, T.H.1
Bucher, K.2
Chung, G.3
Grutz, G.4
Warren, A.5
Yamada, Y.6
-
6
-
-
0026131054
-
Safety issues related to retroviral-mediated gene transfer in humans
-
Cornetta, K, Morgan, RA and Anderson, WF (1991). Safety issues related to retroviral-mediated gene transfer in humans. Hum Gene Ther 2 5-14.
-
(1991)
Hum Gene Ther
, vol.2
, pp. 5-14
-
-
Cornetta, K.1
Morgan, R.A.2
Anderson, W.F.3
-
7
-
-
0028902269
-
Insights into lymphocyte development from X-linked immune deficiencies
-
Belmont, JW (1995). Insights into lymphocyte development from X-linked immune deficiencies. Trends Genet 11: 112-116.
-
(1995)
Trends Genet
, vol.11
, pp. 112-116
-
-
Belmont, J.W.1
-
8
-
-
0031722417
-
X-linked SCID and other defects of cytokine pathways
-
Uribe, L and Weinberg, KI (1998). X-linked SCID and other defects of cytokine pathways. Semin Hematol 35: 299-309.
-
(1998)
Semin Hematol
, vol.35
, pp. 299-309
-
-
Uribe, L.1
Weinberg, K.I.2
-
9
-
-
0031890341
-
Interleukin-7, a non-redundant potent cytokine whose over-expression massively perturbs B-lymphopoiesis
-
Mertsching, E, Meyer, V, Linares, J, Lombard-Platet, S and Ceredig, R (1998). Interleukin-7, a non-redundant potent cytokine whose over-expression massively perturbs B-lymphopoiesis. Int Rev Immunol 16: 285-308.
-
(1998)
Int Rev Immunol
, vol.16
, pp. 285-308
-
-
Mertsching, E.1
Meyer, V.2
Linares, J.3
Lombard-Platet, S.4
Ceredig, R.5
-
10
-
-
0034657369
-
Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer
-
Soudais, C, Shiho, T, Sharara, LI, Guy-Grand, D, Taniguchi, T, Fischer, A et al. (2000). Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer. Blood 95: 3071-3077.
-
(2000)
Blood
, vol.95
, pp. 3071-3077
-
-
Soudais, C.1
Shiho, T.2
Sharara, L.I.3
Guy-Grand, D.4
Taniguchi, T.5
Fischer, A.6
-
11
-
-
0347634456
-
Gene therapy insertional mutagenesis insights
-
Dave, UP, Jenkins, NA and Copeland, NG (2004). Gene therapy insertional mutagenesis insights. Science 303: 333.
-
(2004)
Science
, vol.303
, pp. 333
-
-
Dave, U.P.1
Jenkins, N.A.2
Copeland, N.G.3
-
12
-
-
33646361846
-
Therapeutic gene causing lymphoma
-
Woods, NB, Bottero, V, Schmidt, M, von Kalle, C and Verma, IM (2006). Therapeutic gene causing lymphoma. Nature 440: 1123.
-
(2006)
Nature
, vol.440
, pp. 1123
-
-
Woods, N.B.1
Bottero, V.2
Schmidt, M.3
von Kalle, C.4
Verma, I.M.5
-
14
-
-
0024558096
-
Human CD2 3′-flanking sequences confer high-level T cell-specific, position-independent gene expression in transgenic mice
-
Greaves, DR, Wilson, FD, Lang, G and Kioussis, D (1989). Human CD2 3′-flanking sequences confer high-level T cell-specific, position-independent gene expression in transgenic mice. Cell 56: 979-986.
-
(1989)
Cell
, vol.56
, pp. 979-986
-
-
Greaves, D.R.1
Wilson, F.D.2
Lang, G.3
Kioussis, D.4
-
15
-
-
0027469732
-
Conditional expression and oncogenicity of a human c-myc transgene linked to a human CD2 dominant control region
-
Stewart, MA, Cameron, E, Toth, S, Campbell, M, McFarlane, R, Onions, D et al. (1993). Conditional expression and oncogenicity of a human c-myc transgene linked to a human CD2 dominant control region. Int J Cancer 53: 1023-1030.
-
(1993)
Int J Cancer
, vol.53
, pp. 1023-1030
-
-
Stewart, M.A.1
Cameron, E.2
Toth, S.3
Campbell, M.4
McFarlane, R.5
Onions, D.6
-
16
-
-
0029841552
-
T-cell lymphomas in v-myb transgenic mice
-
Badiani, PA, Kioussis, D, Swirsky, DM, Lampert, TA and Weston, K (1996). T-cell lymphomas in v-myb transgenic mice. Oncogene 13: 2205-2212.
-
(1996)
Oncogene
, vol.13
, pp. 2205-2212
-
-
Badiani, P.A.1
Kioussis, D.2
Swirsky, D.M.3
Lampert, T.A.4
Weston, K.5
-
17
-
-
0033576570
-
Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: Evidence for cooperation between cyclin E and Ras but not Myc
-
Karsunky, H, Geisen, C, Schmidt, T, Haas, K, Zevnik, B, Gau, E et al. (1999). Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: Evidence for cooperation between cyclin E and Ras but not Myc. Oncogene 18: 7816-7824.
-
(1999)
Oncogene
, vol.18
, pp. 7816-7824
-
-
Karsunky, H.1
Geisen, C.2
Schmidt, T.3
Haas, K.4
Zevnik, B.5
Gau, E.6
-
18
-
-
0033604455
-
A full length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC
-
Vaillant, F, Blyth, K, Terry, A, Bell, M, Cameron, E, Neil, J et al. (1999). A full length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC. Oncogene 18 7124-7134.
-
(1999)
Oncogene
, vol.18
, pp. 7124-7134
-
-
Vaillant, F.1
Blyth, K.2
Terry, A.3
Bell, M.4
Cameron, E.5
Neil, J.6
-
19
-
-
33750727669
-
CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy
-
Turner, SD, Merz, H, Yeung, D and Alexander, DR (2006). CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy. Anticancer Res 26: 3275-3279.
-
(2006)
Anticancer Res
, vol.26
, pp. 3275-3279
-
-
Turner, S.D.1
Merz, H.2
Yeung, D.3
Alexander, D.R.4
-
20
-
-
43449100337
-
Cooperation of Gata3c-Myc and Notch in malignant transforamtion of double postivie thymocytes
-
van Hamburg, JP, de Bruijn, MJ, Dingjan, GM, Beverloo, HB, Diepstraten, H, Ling, KW et al. (2008). Cooperation of Gata3c-Myc and Notch in malignant transforamtion of double postivie thymocytes. Mol Immunol 45: 3085-3095.
-
(2008)
Mol Immunol
, vol.45
, pp. 3085-3095
-
-
van Hamburg, J.P.1
de Bruijn, M.J.2
Dingjan, G.M.3
Beverloo, H.B.4
Diepstraten, H.5
Ling, K.W.6
-
21
-
-
0020993055
-
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours
-
Bernard, O, Cory, S, Gerondakis, S, Webb, E and Adams, JM (1983). Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours. EMBO J 2: 2375-2383.
-
(1983)
EMBO J
, vol.2
, pp. 2375-2383
-
-
Bernard, O.1
Cory, S.2
Gerondakis, S.3
Webb, E.4
Adams, J.M.5
-
22
-
-
0024595556
-
Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
-
van Lohuizen, M, Verbeek, S, Krimpenfort, P, Domen, J, Saris, C, Radaszkiewicz, T et al. (1989). Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 56: 673-682.
-
(1989)
Cell
, vol.56
, pp. 673-682
-
-
van Lohuizen, M.1
Verbeek, S.2
Krimpenfort, P.3
Domen, J.4
Saris, C.5
Radaszkiewicz, T.6
-
23
-
-
0035905751
-
Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging
-
Blyth, K, Terry, A, Mackay, N, Vaillant, F, Cameron, E, Neil, JC et al. (2001). Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene 20: 295-302.
-
(2001)
Oncogene
, vol.20
, pp. 295-302
-
-
Blyth, K.1
Terry, A.2
Mackay, N.3
Vaillant, F.4
Cameron, E.5
Neil, J.C.6
-
24
-
-
27944496521
-
Retroviral insertional mutagenesis: Past, present and future
-
Uren, AG, Kool, J, Berns, A and van Lohuizen, M (2005). Retroviral insertional mutagenesis: Past, present and future. Oncogene 24 7656-7672.
-
(2005)
Oncogene
, vol.24
, pp. 7656-7672
-
-
Uren, A.G.1
Kool, J.2
Berns, A.3
van Lohuizen, M.4
-
25
-
-
0031081594
-
Leukemogenesis by Moloney murine leukemia virus: A multistep process
-
Fan, H (1997). Leukemogenesis by Moloney murine leukemia virus: A multistep process. Trends Microbiol 5: 74-82.
-
(1997)
Trends Microbiol
, vol.5
, pp. 74-82
-
-
Fan, H.1
-
26
-
-
0037332003
-
Transgenic mice with hematopoietic and lymphoid specific expression of Cre
-
de Boer, J, Williams, A, Skavdis, G, Harker, N, Coles, M, Tolaini, M et al. (2003). Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol 33: 314-325.
-
(2003)
Eur J Immunol
, vol.33
, pp. 314-325
-
-
de Boer, J.1
Williams, A.2
Skavdis, G.3
Harker, N.4
Coles, M.5
Tolaini, M.6
-
27
-
-
0029892554
-
Retroviral insertional mutagenesis as a strategy to identify cancer genes
-
Jonkers, J and Berns, A (1996). Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta 1287 29-57.
-
(1996)
Biochim Biophys Acta
, vol.1287
, pp. 29-57
-
-
Jonkers, J.1
Berns, A.2
-
28
-
-
0030052663
-
Til-1, a novel insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice
-
Stewart, MA, Terry, A, O'Hara, M, Cameron, ER, Onions, DE and Neil, JC (1996). Til-1, a novel insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice. J Gen Virol 77 443-446.
-
(1996)
J Gen Virol
, vol.77
, pp. 443-446
-
-
Stewart, M.A.1
Terry, A.2
O'Hara, M.3
Cameron, E.R.4
Onions, D.E.5
Neil, J.C.6
-
29
-
-
0029060361
-
Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: Contrasting effects of homozygous and heterozygous p53 loss
-
Blyth, K, Terry, A, O'Hara, M, Baxter, EW, Campbell, M, Stewart, M et al. (1995). Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: Contrasting effects of homozygous and heterozygous p53 loss. Oncogene 10: 1717-1723.
-
(1995)
Oncogene
, vol.10
, pp. 1717-1723
-
-
Blyth, K.1
Terry, A.2
O'Hara, M.3
Baxter, E.W.4
Campbell, M.5
Stewart, M.6
-
30
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower, LA, Harvey, M, Slagle, BL, McArthur, MJ, Montgomery, CA, Butel, JS et al. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery, C.A.5
Butel, J.S.6
-
31
-
-
0034628513
-
Sensitivity to Myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice
-
Blyth, K, Stewart, M, Bell, M, James, C, Evan, G, Neil, JC et al. (2000). Sensitivity to Myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. Oncogene 19: 773-782.
-
(2000)
Oncogene
, vol.19
, pp. 773-782
-
-
Blyth, K.1
Stewart, M.2
Bell, M.3
James, C.4
Evan, G.5
Neil, J.C.6
-
32
-
-
0028878330
-
Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor γ chain
-
Disanto, JP, Müller, W, Guy-grand, D, Fischer, A and Rajewsky, K (1995). Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor γ chain. Proc Natl Acad Sci USA 92: 377-381.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 377-381
-
-
Disanto, J.P.1
Müller, W.2
Guy-grand, D.3
Fischer, A.4
Rajewsky, K.5
-
33
-
-
4544371118
-
Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation
-
Schuringa, JJ, Chung, KY, Morrone, G and Moore, MA (2004). Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med 200: 623-635.
-
(2004)
J Exp Med
, vol.200
, pp. 623-635
-
-
Schuringa, J.J.1
Chung, K.Y.2
Morrone, G.3
Moore, M.A.4
-
34
-
-
0029864365
-
Critical role for the common cytokine receptor γ chain in intrathymic and peripheral T cell selection
-
Disanto, JP, Guygrand, D, Fisher, A and Tarakhovsky, A (1996). Critical role for the common cytokine receptor γ chain in intrathymic and peripheral T cell selection. J Exp Med 183: 1111-1118.
-
(1996)
J Exp Med
, vol.183
, pp. 1111-1118
-
-
Disanto, J.P.1
Guygrand, D.2
Fisher, A.3
Tarakhovsky, A.4
-
35
-
-
33748939587
-
Gene therapy: X-SCID transgene leukaemogenicity
-
Thrasher, AJ, Gasper, HB, Baum, C, Modlich, U, Schambach, A, Candotti, F et al. (2006). Gene therapy: X-SCID transgene leukaemogenicity. Nature 443: E5-E6.
-
(2006)
Nature
, vol.443
-
-
Thrasher, A.J.1
Gasper, H.B.2
Baum, C.3
Modlich, U.4
Schambach, A.5
Candotti, F.6
-
36
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
Hacein-Bey-Abina, S, Garrigue, A, Wang, GP, Soulier, J, Lim, A, Morillon, E et al. (2008). Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 118: 3132-3142.
-
(2008)
J Clin Invest
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
Soulier, J.4
Lim, A.5
Morillon, E.6
-
37
-
-
51349158298
-
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
Howe, SJ, Mansour, MR, Schwarzwaelder, K, Bartholomae, C, Hubank, M, Kempski, H et al. (2008). Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 118: 3143-3150.
-
(2008)
J Clin Invest
, vol.118
, pp. 3143-3150
-
-
Howe, S.J.1
Mansour, M.R.2
Schwarzwaelder, K.3
Bartholomae, C.4
Hubank, M.5
Kempski, H.6
-
38
-
-
33646580781
-
Mediator is a transducer of Wnt/β-catenin signaling
-
Kim, S, Xu, X, Hecht, A and Boyer, TG (2006). Mediator is a transducer of Wnt/β-catenin signaling. J Biol Chem 281: 14066-14075.
-
(2006)
J Biol Chem
, vol.281
, pp. 14066-14075
-
-
Kim, S.1
Xu, X.2
Hecht, A.3
Boyer, T.G.4
-
39
-
-
0036780602
-
Retroviral insertion sites and cancer: Fountain of all knowledge?
-
Neil, JC and Cameron, ER (2002). Retroviral insertion sites and cancer: Fountain of all knowledge? Cancer Cell 2: 253-255.
-
(2002)
Cancer Cell
, vol.2
, pp. 253-255
-
-
Neil, J.C.1
Cameron, E.R.2
-
40
-
-
33746801652
-
Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy
-
Shou, Y, Ma, ZJ, Lu, T and Sorrentino, BP (2006). Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proc Natl Acad Sci USA 103: 11730-11735.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11730-11735
-
-
Shou, Y.1
Ma, Z.J.2
Lu, T.3
Sorrentino, B.P.4
-
41
-
-
33645451483
-
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
-
Baum, C, Kustikova, O, Modlich, U, Li, ZX and Fehse, B (2006). Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther 17: 253-263.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 253-263
-
-
Baum, C.1
Kustikova, O.2
Modlich, U.3
Li, Z.X.4
Fehse, B.5
-
42
-
-
34548843603
-
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
-
Zhang, F, Thornhill, SI, Howe, SJ, Ulaganathan, M, Scharnbach, A, Sinclair, J et al. (2007). Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 110: 1448-1457.
-
(2007)
Blood
, vol.110
, pp. 1448-1457
-
-
Zhang, F.1
Thornhill, S.I.2
Howe, S.J.3
Ulaganathan, M.4
Scharnbach, A.5
Sinclair, J.6
-
43
-
-
0029037960
-
Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
-
Zhumabekov, T, Corbella, P, Tolaini, M and Kioussis, D (1995). Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods 185: 133-140.
-
(1995)
J Immunol Methods
, vol.185
, pp. 133-140
-
-
Zhumabekov, T.1
Corbella, P.2
Tolaini, M.3
Kioussis, D.4
-
44
-
-
0003799070
-
-
2nd edn. Cold Spring Harbot Laboratory Publications: New York
-
Hogan, B, Beddington, R, Constantini, F and Lacey, E (1994). Manipulating the Mouse Embryo: A Laboratory Manual, 2nd edn. Cold Spring Harbot Laboratory Publications: New York.
-
(1994)
Manipulating the Mouse Embryo: A Laboratory Manual
-
-
Hogan, B.1
Beddington, R.2
Constantini, F.3
Lacey, E.4
-
45
-
-
0031753237
-
Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor γ chain
-
Goldman, JP, Blundell, MP, Lopes, L, Kinnon, C, Di Santo, JP and Thrasher, AJ (1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor γ chain. Br J Haematol 103: 335-342.
-
(1998)
Br J Haematol
, vol.103
, pp. 335-342
-
-
Goldman, J.P.1
Blundell, M.P.2
Lopes, L.3
Kinnon, C.4
Di Santo, J.P.5
Thrasher, A.J.6
|