-
1
-
-
84904354529
-
-
[cited December 09, 2012]; Available at: Accessed 7 Sept 2013
-
2011 [cited December 09, 2012]; Available at: http://www.who.int/ mediacentre/factsheets/fs310/en/index.html. Accessed 7 Sept 2013.
-
(2011)
-
-
-
2
-
-
80054813853
-
Prevalence of coronary heart disease - United States, 2006-2010
-
Prevalence of coronary heart disease - United States, 2006-2010. Morb Mortal Wkly Rep. 2011;60:1377-81.
-
(2011)
Morb Mortal Wkly Rep
, vol.60
, pp. 1377-1381
-
-
-
3
-
-
0035811026
-
High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults evidence from intravascular ultrasound
-
Tuzcu EM, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, et al. High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation. 2001;103:2705-10. (Pubitemid 32538786)
-
(2001)
Circulation
, vol.103
, Issue.22
, pp. 2705-2710
-
-
Tuzcu, E.M.1
Kapadia, S.R.2
Tutar, E.3
Ziada, K.M.4
Hobbs, R.E.5
McCarthy, P.M.6
Young, J.B.7
Nissen, S.E.8
-
4
-
-
4444382796
-
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study
-
DOI 10.1016/S0140-6736(04)17018-9, PII S0140673604170189
-
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case - control study. Lancet. 2004;364:937-52. (Pubitemid 39208455)
-
(2004)
Lancet
, vol.364
, Issue.9438
, pp. 937-952
-
-
Yusuf, P.S.1
Hawken, S.2
Ounpuu, S.3
Dans, T.4
Avezum, A.5
Lanas, F.6
McQueen, M.7
Budaj, A.8
Pais, P.9
Varigos, J.10
Lisheng, L.11
-
5
-
-
84867861639
-
Genes and coronary artery disease: Where are we?
-
Roberts R, Stewart AFR. Genes and coronary artery disease: where are we? J Am Coll Cardiol. 2012;60:1715-21.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 1715-1721
-
-
Roberts, R.1
Stewart, A.F.R.2
-
6
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-78.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
7
-
-
34250010480
-
A common variant on chromosome 9p21 affects the risk of myocardial infarction
-
DOI 10.1126/science.1142842
-
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491-3. (Pubitemid 46906618)
-
(2007)
Science
, vol.316
, Issue.5830
, pp. 1491-1493
-
-
Helgadottir, A.1
Thorleifsson, G.2
Manolescu, A.3
Gretarsdottir, S.4
Blondal, T.5
Jonasdottir, A.6
Jonasdottir, A.7
Sigurdsson, A.8
Baker, A.9
Palsson, A.10
Masson, G.11
Gudbjartsson, D.F.12
Magnusson, K.P.13
Andersen, K.14
Levey, A.I.15
Backman, V.M.16
Matthiasdottir, S.17
Jonsdottir, T.18
Palsson, S.19
Einarsdottir, H.20
Gunnarsdottir, S.21
Gylfason, A.22
Vaccarino, V.23
Hooper, W.C.24
Reilly, M.P.25
Granger, C.B.26
Austin, H.27
Rader, D.J.28
Shah, S.H.29
Quyyumi, A.A.30
Gulcher, J.R.31
Thorgeirsson, G.32
Thorsteinsdottir, U.33
Kong, A.34
Stefansson, K.35
more..
-
8
-
-
34249996115
-
A common allele on chromosome 9 associated with coronary heart disease
-
DOI 10.1126/science.1142447
-
McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al.A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-91. (Pubitemid 46906617)
-
(2007)
Science
, vol.316
, Issue.5830
, pp. 1488-1491
-
-
McPherson, R.1
Pertsemlidis, A.2
Kavaslar, N.3
Stewart, A.4
Roberts, R.5
Cox, D.R.6
Hinds, D.A.7
Pennacchio, L.A.8
Tybjaerg-Hansen, A.9
Folsom, A.R.10
Boerwinkle, E.11
Hobbs, H.H.12
Cohen, J.C.13
-
9
-
-
84871969762
-
Large-scale association analysis identifies new risk loci for coronary artery disease
-
Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013;45:25-33.
-
(2013)
Nat Genet
, vol.45
, pp. 25-33
-
-
Deloukas, P.1
Kanoni, S.2
Willenborg, C.3
Farrall, M.4
Assimes, T.L.5
Thompson, J.R.6
-
10
-
-
56349096706
-
Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
-
Anderson JL, Horne BD, Kolek MJ, Muhlestein JB, Mower CP, Park JJ, et al. Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility. Am Heart J. 2008;156:1155-62, e2.
-
(2008)
Am Heart J
, vol.156
-
-
Anderson, J.L.1
Horne, B.D.2
Kolek, M.J.3
Muhlestein, J.B.4
Mower, C.P.5
Park, J.J.6
-
11
-
-
0032510639
-
Prediction of coronary heart disease using risk factor categories
-
Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837-47. (Pubitemid 28213628)
-
(1998)
Circulation
, vol.97
, Issue.18
, pp. 1837-1847
-
-
Wilson, P.W.F.1
D'Agostino, R.B.2
Levy, D.3
Belanger, A.M.4
Silbershatz, H.5
Kannel, W.B.6
-
12
-
-
84857653989
-
Regulation of lipid droplet cholesterol efflux from macrophage foam cells
-
Ouimet M, Marcel YL. Regulation of lipid droplet cholesterol efflux from macrophage foam cells. Arterioscler Thromb Vasc Biol. 2012;32:575-81.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 575-581
-
-
Ouimet, M.1
Marcel, Y.L.2
-
13
-
-
0037022910
-
Inflammation and atherosclerosis
-
DOI 10.1161/hc0902.104353
-
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135-43. (Pubitemid 34212626)
-
(2002)
Circulation
, vol.105
, Issue.9
, pp. 1135-1143
-
-
Libby, P.1
Ridker, P.M.2
Maseri, A.3
-
14
-
-
0033905619
-
Polymerase chain reaction-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: Enhancement by tumor necrosis factor-alpha and interleukin-1beta
-
Kim CJ, Khoo JC, Gillotte-Taylor K, Li A, Palinski W, Glass CK, et al. Polymerase chain reaction-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tumor necrosis factor-alpha and interleukin-1 beta. Arterioscler Thromb Vasc Biol. 2000;20:1976-82. (Pubitemid 30644648)
-
(2000)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.20
, Issue.8
, pp. 1976-1982
-
-
Kim, C.-J.1
Khoo, J.C.2
Gillotte-Taylor, K.3
Li, A.4
Palinski, W.5
Glass, C.K.6
Steinberg, D.7
-
15
-
-
0036081177
-
Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model
-
Lessner SM, Prado HL, Waller EK, Galis ZS. Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model. Am J Pathol. 2002;160:2145-55. (Pubitemid 34663406)
-
(2002)
American Journal of Pathology
, vol.160
, Issue.6
, pp. 2145-2155
-
-
Lessner, S.M.1
Prado, H.L.2
Waller, E.K.3
Galis, Z.S.4
-
16
-
-
33745876256
-
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
-
DOI 10.1073/pnas.0604260103
-
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, et al. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006;103:10340-5. (Pubitemid 44051168)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.27
, pp. 10340-10345
-
-
Swirski, F.K.1
Pittet, M.J.2
Kircher, M.F.3
Aikawa, E.4
Jaffer, F.A.5
Libby, P.6
Weissleder, R.7
-
17
-
-
33845970192
-
hi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
-
DOI 10.1172/JCI29950
-
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117:195-205. (Pubitemid 46048466)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 195-205
-
-
Swirski, F.K.1
Libby, P.2
Aikawa, E.3
Alcaide, P.4
Luscinskas, F.W.5
Weissleder, R.6
Pittet, M.J.7
-
18
-
-
33845989083
-
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
-
DOI 10.1172/JCI28549
-
Tacke F, Alvarez D, Kaplan TJ, Jakubzick C, Spanbroek R, Llodra J, et al.Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117:185-94. (Pubitemid 46048465)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 185-194
-
-
Tacke, F.1
Alvarez, D.2
Kaplan, T.J.3
Jakubzick, C.4
Spanbroek, R.5
Llodra, J.6
Garin, A.7
Liu, J.8
Mack, M.9
Van Rooijen, N.10
Lira, S.A.11
Habenicht, A.J.12
Randolph, G.J.13
-
19
-
-
41649100060
-
Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6Chi and Ly6Clo monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice
-
DOI 10.1161/CIRCULATIONAHA.107.745091
-
Combadiere C, Potteaux S, Rodero M, Simon T, Pezard A, Esposito B, et al. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice. Circulation. 2008;117:1649-57. (Pubitemid 351482605)
-
(2008)
Circulation
, vol.117
, Issue.13
, pp. 1649-1657
-
-
Combadiere, C.1
Potteaux, S.2
Rodero, M.3
Simon, T.4
Pezard, A.5
Esposito, B.6
Merval, R.7
Proudfoot, A.8
Tedgui, A.9
Mallat, Z.10
-
20
-
-
41649107036
-
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: Evidence for independent chemokine functions in atherogenesis
-
DOI 10.1161/CIRCULATIONAHA.107.743872
-
Saederup N, Chan L, Lira SA, Charo IF. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation. 2008;117:1642-8. (Pubitemid 351482604)
-
(2008)
Circulation
, vol.117
, Issue.13
, pp. 1642-1648
-
-
Saederup, N.1
Chan, L.2
Lira, S.A.3
Charo, I.F.4
-
21
-
-
84883800208
-
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
-
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013;19:1166-72.
-
(2013)
Nat Med
, vol.19
, pp. 1166-1172
-
-
Robbins, C.S.1
Hilgendorf, I.2
Weber, G.F.3
Theurl, I.4
Iwamoto, Y.5
Figueiredo, J.L.6
-
22
-
-
84888063933
-
Beyond stem cells: Self-renewal of differentiated macrophages
-
Sieweke MH, Allen JE. Beyond stem cells: self-renewal of differentiated macrophages. Science. 2013;342:1242974.
-
(2013)
Science
, vol.342
, pp. 1242974
-
-
Sieweke, M.H.1
Allen, J.E.2
-
23
-
-
77955438579
-
Gene dosage of the common variant 9p21 predicts severity of coronary artery disease
-
This study was the first to document that the 9p21.3 risk locus associates with atherosclerosis rather than myocardial infarction
-
• Dandona S, Stewart AFR, Chen L, Williams K, So D, O'Brien E, et al.Gene dosage of the common variant 9p21 predicts severity of coronary artery disease. J Am Coll Cardiol. 2010;56:479-86. This study was the first to document that the 9p21.3 risk locus associates with atherosclerosis rather than myocardial infarction.
-
(2010)
J Am Coll Cardiol
, vol.56
, pp. 479-486
-
-
Dandona, S.1
Stewart, A.F.R.2
Chen, L.3
Williams, K.4
So, D.5
O'Brien, E.6
-
24
-
-
78650316598
-
The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease
-
Patel RS, Su S, Neeland IJ, Ahuja A, Veledar E, Zhao J, et al. The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J. 2010;31:3017-23.
-
(2010)
Eur Heart J
, vol.31
, pp. 3017-3023
-
-
Patel, R.S.1
Su, S.2
Neeland, I.J.3
Ahuja, A.4
Veledar, E.5
Zhao, J.6
-
25
-
-
84875453250
-
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: A collaborative meta-analysis
-
Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, et al. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol. 2013;61:957-70.
-
(2013)
J Am Coll Cardiol
, vol.61
, pp. 957-970
-
-
Chan, K.1
Patel, R.S.2
Newcombe, P.3
Nelson, C.P.4
Qasim, A.5
Epstein, S.E.6
-
26
-
-
60349120503
-
Association of genetic variation on chromosome 9p21.3 and arterial stiffness
-
Bjorck HM, Lanne T, Alehagen U, Persson K, Rundkvist L, Hamsten A, et al. Association of genetic variation on chromosome 9p21.3 and arterial stiffness. J Intern Med. 2009;265:373-81.
-
(2009)
J Intern Med
, vol.265
, pp. 373-381
-
-
Bjorck, H.M.1
Lanne, T.2
Alehagen, U.3
Persson, K.4
Rundkvist, L.5
Hamsten, A.6
-
27
-
-
73449113231
-
Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm
-
Bown MJ, Braund PS, Thompson J, London NJ, Samani NJ, Sayers RD. Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm. Circ Cardiovasc Genet. 2008;1:39-42.
-
(2008)
Circ Cardiovasc Genet
, vol.1
, pp. 39-42
-
-
Bown, M.J.1
Braund, P.S.2
Thompson, J.3
London, N.J.4
Samani, N.J.5
Sayers, R.D.6
-
28
-
-
38649091662
-
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
-
DOI 10.1038/ng.72, PII NG72
-
Helgadottir A, Thorleifsson G, Magnusson KP, Gretarsdottir S, Steinthorsdottir V, Manolescu A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet. 2008;40:217-24. (Pubitemid 351171400)
-
(2008)
Nature Genetics
, vol.40
, Issue.2
, pp. 217-224
-
-
Helgadottir, A.1
Thorleifsson, G.2
Magnusson, K.P.3
Gretarsdottir, S.4
Steinthorsdottir, V.5
Manolescu, A.6
Jones, G.T.7
Rinkel, G.J.E.8
Blankensteijn, J.D.9
Ronkainen, A.10
Jaaskelainen, J.E.11
Kyo, Y.12
Lenk, G.M.13
Sakalihasan, N.14
Kostulas, K.15
Gottsater, A.16
Flex, A.17
Stefansson, H.18
Hansen, T.19
Andersen, G.20
Weinsheimer, S.21
Borch-Johnsen, K.22
Jorgensen, T.23
Shah, S.H.24
Quyyumi, A.A.25
Granger, C.B.26
Reilly, M.P.27
Austin, H.28
Levey, A.I.29
Vaccarino, V.30
Palsdottir, E.31
Walters, G.B.32
Jonsdottir, T.33
Snorradottir, S.34
Magnusdottir, D.35
Gudmundsson, G.36
Ferrell, R.E.37
Sveinbjornsdottir, S.38
Hernesniemi, J.39
Niemela, M.40
Limet, R.41
Andersen, K.42
Sigurdsson, G.43
Benediktsson, R.44
Verhoeven, E.L.G.45
Teijink, J.A.W.46
Grobbee, D.E.47
Rader, D.J.48
Collier, D.A.49
Pedersen, O.50
Pola, R.51
Hillert, J.52
Lindblad, B.53
Valdimarsson, E.M.54
Magnadottir, H.B.55
Wijmenga, C.56
Tromp, G.57
Baas, A.F.58
Ruigrok, Y.M.59
Van Rij, A.M.60
Kuivaniemi, H.61
Powell, J.T.62
Matthiasson, S.E.63
Gulcher, J.R.64
Thorgeirsson, G.65
Kong, A.66
Thorsteinsdottir, U.67
Stefansson, K.68
more..
-
29
-
-
60749104192
-
Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion
-
Thompson AR, Golledge J, Cooper JA, Hafez H, Norman PE, Humphries SE. Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. Eur J Hum Genet. 2009;17:391-4.
-
(2009)
Eur J Hum Genet
, vol.17
, pp. 391-394
-
-
Thompson, A.R.1
Golledge, J.2
Cooper, J.A.3
Hafez, H.4
Norman, P.E.5
Humphries, S.E.6
-
30
-
-
77951768060
-
Genome-wide association study of intracranial aneurysm identifies three new risk loci
-
Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet. 2010;42:420-5.
-
(2010)
Nat Genet
, vol.42
, pp. 420-425
-
-
Yasuno, K.1
Bilguvar, K.2
Bijlenga, P.3
Low, S.K.4
Krischek, B.5
Auburger, G.6
-
31
-
-
84868192579
-
Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk
-
Foroud T, Koller DL, Lai D, Sauerbeck L, Anderson C, Ko N, et al. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke.2012;43:2846-52.
-
(2012)
Stroke
, vol.43
, pp. 2846-2852
-
-
Foroud, T.1
Koller, D.L.2
Lai, D.3
Sauerbeck, L.4
Anderson, C.5
Ko, N.6
-
32
-
-
84860862315
-
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genomewide association studies
-
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, et al. Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genomewide association studies. Circ Cardiovasc Genet. 2012;5:100-12.
-
(2012)
Circ Cardiovasc Genet
, vol.5
, pp. 100-112
-
-
Murabito, J.M.1
White, C.C.2
Kavousi, M.3
Sun, Y.V.4
Feitosa, M.F.5
Nambi, V.6
-
33
-
-
77954141778
-
Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease
-
Emanuele E, Lista S, Ghidoni R, Binetti G, Cereda C, Benussi L, et al. Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease. Neurobiol Aging. 2011;32:1231-5.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1231-1235
-
-
Emanuele, E.1
Lista, S.2
Ghidoni, R.3
Binetti, G.4
Cereda, C.5
Benussi, L.6
-
34
-
-
84893659261
-
Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants
-
Dichgans M, Malik R, Konig IR, Rosand J, Clarke R, Gretarsdottir S, et al. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014;45:24-36.
-
(2014)
Stroke
, vol.45
, pp. 24-36
-
-
Dichgans, M.1
Malik, R.2
Konig, I.R.3
Rosand, J.4
Clarke, R.5
Gretarsdottir, S.6
-
35
-
-
77149122355
-
9p21 is a shared susceptibility locus strongly for coronary artery disease and weakly for ischemic stroke in Chinese Han population
-
Ding H, Xu Y, Wang X, Wang Q, Zhang L, Tu Y, et al. 9p21 is a shared susceptibility locus strongly for coronary artery disease and weakly for ischemic stroke in Chinese Han population. Circ Cardiovasc Genet. 2009;2:338-46.
-
(2009)
Circ Cardiovasc Genet
, vol.2
, pp. 338-346
-
-
Ding, H.1
Xu, Y.2
Wang, X.3
Wang, Q.4
Zhang, L.5
Tu, Y.6
-
36
-
-
67249112107
-
Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
-
Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, et al. Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol. 2009;65:531-9.
-
(2009)
Ann Neurol
, vol.65
, pp. 531-539
-
-
Gschwendtner, A.1
Bevan, S.2
Cole, J.W.3
Plourde, A.4
Matarin, M.5
Ross-Adams, H.6
-
37
-
-
44449176689
-
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21
-
Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. Stroke. 2008;39:1586-9.
-
(2008)
Stroke
, vol.39
, pp. 1586-1589
-
-
Matarin, M.1
Brown, W.M.2
Singleton, A.3
Hardy, J.A.4
Meschia, J.F.5
-
38
-
-
70349569056
-
Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus
-
This study was the first to identify functional enhancers at the 9p21.3 risk locus
-
• Jarinova O, Stewart AFR, Roberts R, Wells G, Lau P, Naing T, et al. Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol. 2009;29:1671-7. This study was the first to identify functional enhancers at the 9p21.3 risk locus.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1671-1677
-
-
Jarinova, O.1
Stewart, A.F.R.2
Roberts, R.3
Wells, G.4
Lau, P.5
Naing, T.6
-
39
-
-
77949775636
-
Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice
-
This study demonstrated that the 9p21.3 syntenic sequences in mouse chromosome 4 contain enhancer sequences that regulate CDKN2A and CDKN2B expression
-
•• Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, et al. Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice. Nature. 2010;464:409-12. This study demonstrated that the 9p21.3 syntenic sequences in mouse chromosome 4 contain enhancer sequences that regulate CDKN2A and CDKN2B expression.
-
(2010)
Nature
, vol.464
, pp. 409-412
-
-
Visel, A.1
Zhu, Y.2
May, D.3
Afzal, V.4
Gong, E.5
Attanasio, C.6
-
40
-
-
79951473520
-
9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response
-
This study proposed a mechanism whereby a SNP at the 9p21.3 locus confers risk for CAD. This study also demonstrated long-range effects of the enhancer sequences at the 9p21.3 locus, modifying chromatin structure in the vicinity of type 1 interferon genes, but see references 41, 42, and 81
-
• Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, et al. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature. 2011;470:264-8. This study proposed a mechanism whereby a SNP at the 9p21.3 locus confers risk for CAD. This study also demonstrated long-range effects of the enhancer sequences at the 9p21.3 locus, modifying chromatin structure in the vicinity of type 1 interferon genes, but see references 41, 42, and 81.
-
(2011)
Nature
, vol.470
, pp. 264-268
-
-
Harismendy, O.1
Notani, D.2
Song, X.3
Rahim, N.G.4
Tanasa, B.5
Heintzman, N.6
-
41
-
-
84885004085
-
The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons
-
This study failed to find an effect of the 9p21.3 locus on type 1 interferon expression in plasma of healthy donors or in monocyte-derived macrophages
-
• Erridge C, Gracey J, Braund PS, Samani NJ. The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons. J Am Coll Cardiol. 2013;62:1376-81. This study failed to find an effect of the 9p21.3 locus on type 1 interferon expression in plasma of healthy donors or in monocyte-derived macrophages.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 1376-1381
-
-
Erridge, C.1
Gracey, J.2
Braund, P.S.3
Samani, N.J.4
-
42
-
-
84875051171
-
Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus
-
This study compared whole genome RNA expression profiles of monocyte-derived macrophages from 9p21.3-genotyped CAD patients and found no difference in type 1 interferon expression
-
• Zollbrecht C, Grassl M, Fenk S, Hocherl R, Hubauer U, Reinhard W, et al. Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus. Atherosclerosis. 2013;227:244-9. This study compared whole genome RNA expression profiles of monocyte-derived macrophages from 9p21.3-genotyped CAD patients and found no difference in type 1 interferon expression.
-
(2013)
Atherosclerosis
, vol.227
, pp. 244-249
-
-
Zollbrecht, C.1
Grassl, M.2
Fenk, S.3
Hocherl, R.4
Hubauer, U.5
Reinhard, W.6
-
43
-
-
33846876333
-
Predicting tissue-specific enhancers in the human genome
-
DOI 10.1101/gr.5972507
-
Pennacchio LA, Loots GG, Nobrega MA, Ovcharenko I. Predicting tissue-specific enhancers in the human genome. Genome Res. 2007;17:201-11. (Pubitemid 46220765)
-
(2007)
Genome Research
, vol.17
, Issue.2
, pp. 201-211
-
-
Pennacchio, L.A.1
Loots, G.G.2
Nobrega, M.A.3
Ovcharenko, I.4
-
44
-
-
84884515412
-
Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk
-
This study identified an additional haplotype at the 9p21.3 locus that associates with myocardial infarction in carriers of the 9p21.3 non-risk allele, consistent with reference 45
-
• Fan M, Dandona S, McPherson R, Allayee H, Hazen SL, Wells GA, et al. Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circ Cardiovasc Genet. 2013;6:372-80. This study identified an additional haplotype at the 9p21.3 locus that associates with myocardial infarction in carriers of the 9p21.3 non-risk allele, consistent with reference 45.
-
(2013)
Circ Cardiovasc Genet
, vol.6
, pp. 372-380
-
-
Fan, M.1
Dandona, S.2
McPherson, R.3
Allayee, H.4
Hazen, S.L.5
Wells, G.A.6
-
45
-
-
78649354925
-
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: A potential mechanism for increased vascular disease
-
This study was the first to identify additional phenotypes tied to platelet reactivity in the vicinity of the 9p21.3 CAD risk locus
-
• Musunuru K, Post WS, Herzog W, Shen H, O 'Connell JR, McArdle PF, et al. Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet. 2010;3:445-53. This study was the first to identify additional phenotypes tied to platelet reactivity in the vicinity of the 9p21.3 CAD risk locus.
-
(2010)
Circ Cardiovasc Genet
, vol.3
, pp. 445-453
-
-
Musunuru, K.1
Post, W.S.2
Herzog, W.3
Shen, H.4
O'Connell, J.R.5
McArdle, P.F.6
-
46
-
-
84880765249
-
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance
-
Wong CH, Jenne CN, Petri B, Chrobok NL, Kubes P. Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol. 2013;14:785-92.
-
(2013)
Nat Immunol
, vol.14
, pp. 785-792
-
-
Wong, C.H.1
Jenne, C.N.2
Petri, B.3
Chrobok, N.L.4
Kubes, P.5
-
47
-
-
84861724751
-
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma
-
Osman W, Low SK, Takahashi A, Kubo M, Nakamura Y. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet. 2012;21:2836-42.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 2836-2842
-
-
Osman, W.1
Low, S.K.2
Takahashi, A.3
Kubo, M.4
Nakamura, Y.5
-
48
-
-
84863614114
-
Common variants on chromosome 9p21 are associated with normal tension glaucoma
-
Takamoto M, Kaburaki T, Mabuchi A, Araie M, Amano S, Aihara M, et al. Common variants on chromosome 9p21 are associated with normal tension glaucoma. PLoS One. 2012;7:e40107.
-
(2012)
PLoS One
, vol.7
-
-
Takamoto, M.1
Kaburaki, T.2
Mabuchi, A.3
Araie, M.4
Amano, S.5
Aihara, M.6
-
49
-
-
84860556002
-
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
-
Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, et al. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012;8:e1002654.
-
(2012)
PLoS Genet
, vol.8
-
-
Wiggs, J.L.1
Yaspan, B.L.2
Hauser, M.A.3
Kang, J.H.4
Allingham, R.R.5
Olson, L.M.6
-
50
-
-
84870988159
-
Genome-wide association study of glioma and meta-analysis
-
Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, et al.Genome-wide association study of glioma and meta-analysis. Hum Genet. 2012;131:1877-88.
-
(2012)
Hum Genet
, vol.131
, pp. 1877-1888
-
-
Rajaraman, P.1
Melin, B.S.2
Wang, Z.3
McKean-Cowdin, R.4
Michaud, D.S.5
Wang, S.S.6
-
51
-
-
68149180890
-
Genome-wide association study identifies five susceptibility loci for glioma
-
Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009;41:899-904.
-
(2009)
Nat Genet
, vol.41
, pp. 899-904
-
-
Shete, S.1
Hosking, F.J.2
Robertson, L.B.3
Dobbins, S.E.4
Sanson, M.5
Malmer, B.6
-
52
-
-
79960905856
-
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
-
Parra EJ, Below JE, Krithika S, Valladares A, Barta JL, Cox NJ, et al. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. Diabetologia. 2011;54:2038-46.
-
(2011)
Diabetologia
, vol.54
, pp. 2038-2046
-
-
Parra, E.J.1
Below, J.E.2
Krithika, S.3
Valladares, A.4
Barta, J.L.5
Cox, N.J.6
-
53
-
-
84861614905
-
A genome-wide approach accounting for bodymass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
-
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, et al.A genome-wide approach accounting for bodymass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012;44:659-69.
-
(2012)
Nat Genet
, vol.44
, pp. 659-669
-
-
Manning, A.K.1
Hivert, M.F.2
Scott, R.A.3
Grimsby, J.L.4
Bouatia-Naji, N.5
Chen, H.6
-
54
-
-
84865605323
-
Early reduction of microglia activation by irradiation in a model of chronic glaucoma
-
Bosco A, Crish SD, Steele MR, Romero CO, Inman DM, Horner PJ, et al. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One. 2012;7:e43602.
-
(2012)
PLoS One
, vol.7
-
-
Bosco, A.1
Crish, S.D.2
Steele, M.R.3
Romero, C.O.4
Inman, D.M.5
Horner, P.J.6
-
55
-
-
79955943750
-
Microglial activation in the visual pathway in experimental glaucoma: Spatiotemporal characterization and correlation with axonal injury
-
Ebneter A, Casson RJ, Wood JP, Chidlow G.Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury. Invest Ophthalmol Vis Sci. 2010;51:6448-60.
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 6448-6460
-
-
Ebneter, A.1
Casson, R.J.2
Wood, J.P.3
Chidlow, G.4
-
56
-
-
84862535639
-
Gliosis vs glioma? Don't grade until you know
-
Rivera-Zengotita M, Yachnis AT. Gliosis vs glioma? Don't grade until you know. Adv Anat Pathol. 2012;19:239-49.
-
(2012)
Adv Anat Pathol
, vol.19
, pp. 239-249
-
-
Rivera-Zengotita, M.1
Yachnis, A.T.2
-
57
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
DOI 10.1038/nn2014, PII NN2014
-
Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007;10:1538-43. (Pubitemid 350175883)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.12
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.V.5
-
58
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
DOI 10.2337/db06-1650
-
Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes. 2007;56:2356-70. (Pubitemid 47358243)
-
(2007)
Diabetes
, vol.56
, Issue.9
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
Ribaux, P.4
Pospisilik, J.A.5
Maor-Cahn, R.6
Gueripel, X.7
Ellingsgaard, H.8
Schneider, M.K.J.9
Biollaz, G.10
Fontana, A.11
Reinecke, M.12
Homo-Delarche, F.13
Donath, M.Y.14
-
59
-
-
84867276514
-
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice
-
Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, et al. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012;126:1896-906.
-
(2012)
Circulation
, vol.126
, pp. 1896-1906
-
-
Kim, J.B.1
Deluna, A.2
Mungrue, I.N.3
Vu, C.4
Pouldar, D.5
Civelek, M.6
-
60
-
-
33947201809
-
Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome
-
DOI 10.1016/j.cell.2006.12.048, PII S009286740700205X
-
Kim TH, Abdullaev ZK, Smith AD, Ching KA, Loukinov DI, Green RD, et al. Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell. 2007;128:1231-45. (Pubitemid 46427876)
-
(2007)
Cell
, vol.128
, Issue.6
, pp. 1231-1245
-
-
Kim, T.H.1
Abdullaev, Z.K.2
Smith, A.D.3
Ching, K.A.4
Loukinov, D.I.5
Green, R.D.6
Zhang, M.Q.7
Lobanenkov, V.V.8
Ren, B.9
-
61
-
-
75749142713
-
CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus
-
Rodriguez C, Borgel J, Court F, Cathala G, Forne T, Piette J. CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus. Biochem Biophys Res Commun. 2010;392:129-34.
-
(2010)
Biochem Biophys Res Commun
, vol.392
, pp. 129-134
-
-
Rodriguez, C.1
Borgel, J.2
Court, F.3
Cathala, G.4
Forne, T.5
Piette, J.6
-
62
-
-
65549159993
-
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
-
Witcher M, Emerson BM. Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell. 2009;34:271-84.
-
(2009)
Mol Cell
, vol.34
, pp. 271-284
-
-
Witcher, M.1
Emerson, B.M.2
-
63
-
-
35548990188
-
We gather together: Insulators and genome organization
-
DOI 10.1016/j.gde.2007.08.005, PII S0959437X07001566, Differentiation and Gene Regulation
-
Wallace JA, Felsenfeld G. We gather together: insulators and genome organization. Curr Opin Genet Dev. 2007;17:400-7. (Pubitemid 350016897)
-
(2007)
Current Opinion in Genetics and Development
, vol.17
, Issue.5
, pp. 400-407
-
-
Wallace, J.A.1
Felsenfeld, G.2
-
64
-
-
33747453473
-
Insulators: Exploiting transcriptional and epigenetic mechanisms
-
DOI 10.1038/nrg1925, PII NRG1925
-
Gaszner M, Felsenfeld G. Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet. 2006;7:703-13. (Pubitemid 44260006)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.9
, pp. 703-713
-
-
Gaszner, M.1
Felsenfeld, G.2
-
65
-
-
67549119096
-
CTCF: Master weaver of the genome
-
Phillips JE, Corces VG. CTCF: master weaver of the genome. Cell. 2009;137:1194-211.
-
(2009)
Cell
, vol.137
, pp. 1194-1211
-
-
Phillips, J.E.1
Corces, V.G.2
-
66
-
-
76049126281
-
Allelic skewing of DNA methylation is widespread across the genome
-
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, et al. Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet. 2010;86:196-212.
-
(2010)
Am J Hum Genet
, vol.86
, pp. 196-212
-
-
Schalkwyk, L.C.1
Meaburn, E.L.2
Smith, R.3
Dempster, E.L.4
Jeffries, A.R.5
Davies, M.N.6
-
67
-
-
77954238686
-
Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome
-
Shoemaker R, Deng J, Wang W, Zhang K. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 2010;20:883-9.
-
(2010)
Genome Res
, vol.20
, pp. 883-889
-
-
Shoemaker, R.1
Deng, J.2
Wang, W.3
Zhang, K.4
-
68
-
-
33845647686
-
Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence
-
Kim J, Kim JY, Song KS, Lee YH, Seo JS, Jelinek J, et al. Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence. Biochim Biophys Acta. 2007;1772:72-80.
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 72-80
-
-
Kim, J.1
Kim, J.Y.2
Song, K.S.3
Lee, Y.H.4
Seo, J.S.5
Jelinek, J.6
-
69
-
-
47049083725
-
Detection of altered global DNA methylation in coronary artery disease patients
-
DOI 10.1089/dna.2007.0694
-
Sharma P, Kumar J, Garg G, Kumar A, Patowary A, Karthikeyan G, et al. Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol. 2008;27:357-65. (Pubitemid 351969854)
-
(2008)
DNA and Cell Biology
, vol.27
, Issue.7
, pp. 357-365
-
-
Sharma, P.1
Kumar, J.2
Garg, G.3
Kumar, A.4
Patowary, A.5
Karthikeyan, G.6
Ramakrishnan, L.7
Brahmachari, V.8
Sengupta, S.9
-
70
-
-
79955468280
-
Long noncoding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
-
Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M, et al. Long noncoding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene. 2011;30:1956-62.
-
(2011)
Oncogene
, vol.30
, pp. 1956-1962
-
-
Kotake, Y.1
Nakagawa, T.2
Kitagawa, K.3
Suzuki, S.4
Liu, N.5
Kitagawa, M.6
-
71
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
-
Yap KL, Li S, Munoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010;38:662-74.
-
(2010)
Mol Cell
, vol.38
, pp. 662-674
-
-
Yap, K.L.1
Li, S.2
Munoz-Cabello, A.M.3
Raguz, S.4
Zeng, L.5
Mujtaba, S.6
-
72
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
DOI 10.1038/nature04431, PII NATURE04431
-
Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 2006;439:871-4. (Pubitemid 43255707)
-
(2006)
Nature
, vol.439
, Issue.7078
, pp. 871-874
-
-
Vire, E.1
Brenner, C.2
Deplus, R.3
Blanchon, L.4
Fraga, M.5
Didelot, C.6
Morey, L.7
Van Eynde, A.8
Bernard, D.9
Vanderwinden, J.-M.10
Bollen, M.11
Esteller, M.12
Di, C.L.13
De Launoit, Y.14
Fuks, F.15
-
73
-
-
84867623646
-
Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease
-
Zhuang J, Peng W, Li H, Wang W, Wei Y, Li W, et al. Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease. PLoS One. 2012;7:e47193.
-
(2012)
PLoS One
, vol.7
-
-
Zhuang, J.1
Peng, W.2
Li, H.3
Wang, W.4
Wei, Y.5
Li, W.6
-
74
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
DOI 10.1172/JCI200422475
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004;114:1299-307. (Pubitemid 40385301)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.9
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
75
-
-
84865738718
-
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
-
This study found that p15ink4b and p16ink4a expression is markedly reduced in arterial vascular smooth muscle cells and associated with high cell proliferation in carriers of the 9p21.3 risk allele
-
• Motterle A, Pu X, Wood H, Xiao Q, Gor S, Liang Ng F, et al. Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet. 2012;21:4021-9. This study found that p15ink4b and p16ink4a expression is markedly reduced in arterial vascular smooth muscle cells and associated with high cell proliferation in carriers of the 9p21.3 risk allele.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 4021-4029
-
-
Motterle, A.1
Pu, X.2
Wood, H.3
Xiao, Q.4
Gor, S.5
Liang Ng, F.6
-
76
-
-
43249130490
-
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
-
DOI 10.1128/MCB.02019-07
-
Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol. 2008;28:3457-64. (Pubitemid 351657107)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.10
, pp. 3457-3464
-
-
Kia, S.K.1
Gorski, M.M.2
Giannakopoulos, S.3
Verrijzer, C.P.4
-
77
-
-
84863184726
-
CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma
-
Ottaviani D, Lever E, Mao S, Christova R, Ogunkolade BW, Jones TA, et al. CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma. Nucleic Acids Res. 2012;40:5262-70.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 5262-5270
-
-
Ottaviani, D.1
Lever, E.2
Mao, S.3
Christova, R.4
Ogunkolade, B.W.5
Jones, T.A.6
-
78
-
-
80053501181
-
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1
-
Hu G, Schones DE, Cui K, Ybarra R, Northrup D, Tang Q, et al. Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1. Genome Res. 2011;21:1650-8.
-
(2011)
Genome Res
, vol.21
, pp. 1650-1658
-
-
Hu, G.1
Schones, D.E.2
Cui, K.3
Ybarra, R.4
Northrup, D.5
Tang, Q.6
-
79
-
-
0036800352
-
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes
-
DOI 10.1038/ncb855
-
Huang M, Qian F, Hu Y, Ang C, Li Z, Wen Z. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol. 2002;4:774-81. (Pubitemid 35214771)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.10
, pp. 774-781
-
-
Huang, M.1
Qian, F.2
Hu, Y.3
Ang, C.4
Li, Z.5
Wen, Z.6
-
80
-
-
38049020996
-
Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRG1
-
Cuddapah S, Cui K, Zhao K. Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRG1. FEBS Lett. 2008;582:391-7.
-
(2008)
FEBS Lett
, vol.582
, pp. 391-397
-
-
Cuddapah, S.1
Cui, K.2
Zhao, K.3
-
81
-
-
84871928731
-
Interferon-gamma activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype
-
This study showed that interferon gamma does elevate p15ink4b and p16ink4a expression, but that this occurs primarily through a post-transcriptional mechanism that is independent of the 9p21.3 risk genotype
-
.• Almontashiri NA, Fan M, Cheng BL, Chen HH, Roberts R, Stewart AFR. Interferon-gamma activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype. J Am Coll Cardiol. 2013;61:143-7. This study showed that interferon gamma does elevate p15ink4b and p16ink4a expression, but that this occurs primarily through a post-transcriptional mechanism that is independent of the 9p21.3 risk genotype.
-
(2013)
J Am Coll Cardiol
, vol.61
, pp. 143-147
-
-
Almontashiri, N.A.1
Fan, M.2
Cheng, B.L.3
Chen, H.H.4
Roberts, R.5
Stewart, A.F.R.6
-
82
-
-
0035571608
-
Transforming growth factor-beta1 inhibits macrophage cholesteryl ester accumulation induced by native and oxidized VLDL remnants
-
Argmann CA, Van Den Diepstraten CH, Sawyez CG, Edwards JY, Hegele RA, Wolfe BM, et al. Transforming growth factor-beta1 inhibits macrophage cholesteryl ester accumulation induced by native and oxidized VLDL remnants. Arterioscler Thromb Vasc Biol. 2001;21:2011-8. (Pubitemid 34219755)
-
(2001)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.21
, Issue.12
, pp. 2011-2018
-
-
Argmann, C.A.1
Van Den, D.C.H.2
Sawyez, C.G.3
Edwards, J.Y.4
Hegele, R.A.5
Wolfe, B.M.6
Huff, M.W.7
-
83
-
-
0033968252
-
Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma
-
DOI 10.1074/jbc.275.2.1241
-
Han J, Hajjar DP, Tauras JM, Feng J, Gotto Jr AM, Nicholson AC. Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. J Biol Chem. 2000;275:1241-6. (Pubitemid 30051177)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.2
, pp. 1241-1246
-
-
Han, J.1
Hajjar, D.P.2
Tauras, J.M.3
Feng, J.4
Gotto Jr., A.M.5
Nicholson, A.C.6
-
84
-
-
77953341757
-
TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells
-
Hu YW, Wang Q, Ma X, Li XX, Liu XH, Xiao J, et al. TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. J Atheroscler Thromb. 2010;17:493-502.
-
(2010)
J Atheroscler Thromb
, vol.17
, pp. 493-502
-
-
Hu, Y.W.1
Wang, Q.2
Ma, X.3
Li, X.X.4
Liu, X.H.5
Xiao, J.6
-
85
-
-
0036307946
-
Prognostic significance of plasma concentrations of transforming growth factor-beta in patients with coronary artery disease
-
DOI 10.1097/00019501-200205000-00001
-
Tashiro H, Shimokawa H, Sadamatu K, Yamamoto K. Prognostic significance of plasma concentrations of transforming growth factor-beta in patients with coronary artery disease. Coron Artery Dis. 2002;13:139-43. (Pubitemid 34747960)
-
(2002)
Coronary Artery Disease
, vol.13
, Issue.3
, pp. 139-143
-
-
Tashiro, H.1
Shimokawa, H.2
Sadamatu, K.3
Yamamoto, K.4
Sobel, B.E.5
Maseri, A.6
Yacoub, M.7
-
86
-
-
84891519471
-
Abrogated transforming growth factor beta receptor II (TGFbetaRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis
-
Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, et al. Abrogated transforming growth factor beta receptor II (TGFbetaRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. Eur Heart J. 2013;34:3717-27.
-
(2013)
Eur Heart J
, vol.34
, pp. 3717-3727
-
-
Lievens, D.1
Habets, K.L.2
Robertson, A.K.3
Laouar, Y.4
Winkels, H.5
Rademakers, T.6
-
87
-
-
84864026952
-
Overexpression of TGF-b1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice
-
Reifenberg K, Cheng F, Orning C, Crain J, Kupper I, Wiese E, et al. Overexpression of TGF-b1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice. PLoS One. 2012;7:e40990.
-
(2012)
PLoS One
, vol.7
-
-
Reifenberg, K.1
Cheng, F.2
Orning, C.3
Crain, J.4
Kupper, I.5
Wiese, E.6
-
88
-
-
0346336788
-
Kip1 in hematopoietic progenitor cells increases neointimal macrophage proliferation and accelerates atherosclerosis
-
DOI 10.1182/blood-2003-07-2319
-
Diez-Juan A, Perez P, Aracil M, Sancho D, Bernad A, Sanchez-Madrid F, et al. Selective inactivation of p27(Kip1) in hematopoietic progenitor cells increases neointimal macrophage proliferation and accelerates atherosclerosis. Blood. 2004;103:158-61. (Pubitemid 38029933)
-
(2004)
Blood
, vol.103
, Issue.1
, pp. 158-161
-
-
Diez-Juan, A.1
Perez, P.2
Aracil, M.3
Sancho, D.4
Bernad, A.5
Sanchez-Madrid, F.6
Andres, V.7
-
89
-
-
0026532252
-
Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation
-
Fan K, Ruan Q, Sensenbrenner L, Chen B. Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation. Blood. 1992;79:1679-85.
-
(1992)
Blood
, vol.79
, pp. 1679-1685
-
-
Fan, K.1
Ruan, Q.2
Sensenbrenner, L.3
Chen, B.4
-
90
-
-
0028168242
-
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
-
Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994;371:257-61.
-
(1994)
Nature
, vol.371
, pp. 257-261
-
-
Hannon, G.J.1
Beach, D.2
-
91
-
-
0029153609
-
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
-
Reynisdottir I, Polyak K, Iavarone A, Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 1995;9:1831-45.
-
(1995)
Genes Dev
, vol.9
, pp. 1831-1845
-
-
Reynisdottir, I.1
Polyak, K.2
Iavarone, A.3
Massague, J.4
-
92
-
-
62349129614
-
Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes
-
Vijayachandra K, Higgins W, Lee J, Glick A. Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. Mol Carcinog. 2009;48:181-6.
-
(2009)
Mol Carcinog
, vol.48
, pp. 181-186
-
-
Vijayachandra, K.1
Higgins, W.2
Lee, J.3
Glick, A.4
-
93
-
-
34247539528
-
A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
-
DOI 10.1002/jcb.21255
-
Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: differential roles and regulation of SMAD2 and SMAD3 in TGF-beta signaling. J Cell Biochem. 2007;101:9-33. (Pubitemid 46652569)
-
(2007)
Journal of Cellular Biochemistry
, vol.101
, Issue.1
, pp. 9-33
-
-
Brown, K.A.1
Pietenpol, J.A.2
Moses, H.L.3
-
94
-
-
0028178720
-
Transforming growth factor-b response elements of the skeletal a-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1
-
MacLellan WR, Lee TC, Schwartz RJ, Schneider MD. Transforming growth factor-b response elements of the skeletal a-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. J Biol Chem. 1994;269:16754-60.
-
(1994)
J Biol Chem
, vol.269
, pp. 16754-16760
-
-
MacLellan, W.R.1
Lee, T.C.2
Schwartz, R.J.3
Schneider, M.D.4
-
95
-
-
0038644847
-
Connective tissue growth factor gene regulation: Requirements for its induction by transforming growth factor-beta2 in fibroblasts
-
DOI 10.1074/jbc.M210366200
-
Leask A, Holmes A, Black CM, Abraham DJ. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem. 2003;278:13008-15. (Pubitemid 36800068)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.15
, pp. 13008-13015
-
-
Leask, A.1
Holmes, A.2
Black, C.M.3
Abraham, D.J.4
-
96
-
-
84860354807
-
TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
-
Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, et al. TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 2012;209:479-94.
-
(2012)
J Exp Med
, vol.209
, pp. 479-494
-
-
Fujii, M.1
Toyoda, T.2
Nakanishi, H.3
Yatabe, Y.4
Sato, A.5
Matsudaira, Y.6
-
97
-
-
84891012505
-
Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells
-
Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, et al. Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 2013;5:1611-24.
-
(2013)
Cell Rep
, vol.5
, pp. 1611-1624
-
-
Beyer, T.A.1
Weiss, A.2
Khomchuk, Y.3
Huang, K.4
Ogunjimi, A.A.5
Varelas, X.6
-
98
-
-
84881526483
-
A distant, cis-acting enhancer drives induction of Arf by Tgfbeta in the developing eye
-
This article shows the requirement for the 9p21.3 syntenic region in mouse chromosome 4 for TGFβ-dependent activation of p14ARF from the CDKN2A gene
-
.• Zheng Y, Devitt C, Liu J, Mei J, Skapek SX. A distant, cis-acting enhancer drives induction of Arf by Tgfbeta in the developing eye. Dev Biol. 2013;380:49-57. This article shows the requirement for the 9p21.3 syntenic region in mouse chromosome 4 for TGFβ-dependent activation of p14ARF from the CDKN2A gene.
-
(2013)
Dev Biol
, vol.380
, pp. 49-57
-
-
Zheng, Y.1
Devitt, C.2
Liu, J.3
Mei, J.4
Skapek, S.X.5
-
99
-
-
0028041176
-
Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription
-
Stewart AFR, Larkin SB, Farrance IKG, Mar JH, Hall DE, Ordahl CP. Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. J Biol Chem. 1994;269:3147-50. (Pubitemid 24237621)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.5
, pp. 3147-3150
-
-
Stewart, A.F.R.1
Larkin, S.B.2
Farrance, I.K.G.3
Mar, J.H.4
Hall, D.E.5
Ordahl, C.P.6
-
100
-
-
84866923507
-
Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans
-
Gray LT, Fong KK, Pavelitz T, Weiner AM. Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans. PLoS Genet. 2012;8:e1002972.
-
(2012)
PLoS Genet
, vol.8
-
-
Gray, L.T.1
Fong, K.K.2
Pavelitz, T.3
Weiner, A.M.4
|